Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0139 | 0.4337 | 0.581 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0092 | 0.2213 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0092 | 0.2213 | 0.2069 |
Echinococcus granulosus | c src tyrosine kinase | 0.0092 | 0.2213 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0092 | 0.2213 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0115 | 0.3283 | 0.4398 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0139 | 0.4337 | 0.581 |
Onchocerca volvulus | 0.0092 | 0.2213 | 0.1888 | |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0134 | 0.4144 | 0.5551 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0139 | 0.4337 | 0.581 |
Schistosoma mansoni | tyrosine kinase | 0.0092 | 0.2213 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0092 | 0.2213 | 0.2069 |
Brugia malayi | Protein kinase domain containing protein | 0.0092 | 0.2213 | 0.1771 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0092 | 0.2213 | 0.2069 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0079 | 0.1609 | 0.2155 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0092 | 0.2213 | 0.2069 |
Mycobacterium ulcerans | polyketide synthase | 0.0139 | 0.4337 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0207 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0207 | 0.7465 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0207 | 0.7465 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0147 | 0.473 | 0.6337 |
Brugia malayi | Protein kinase domain containing protein | 0.0092 | 0.2213 | 0.1771 |
Schistosoma mansoni | tyrosine kinase | 0.0092 | 0.2213 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0092 | 0.2213 | 1 |
Onchocerca volvulus | 0.0092 | 0.2213 | 0.1888 | |
Brugia malayi | Protein kinase domain containing protein | 0.0092 | 0.2213 | 0.1771 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0147 | 0.473 | 0.6337 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0092 | 0.2213 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0137 | 0.4253 | 0.4588 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0139 | 0.4337 | 0.581 |
Loa Loa (eye worm) | SRC-1 | 0.0092 | 0.2213 | 0.2069 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0092 | 0.2213 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0092 | 0.2213 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0092 | 0.2213 | 1 |
Onchocerca volvulus | 0.0092 | 0.2213 | 0.1888 | |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0092 | 0.2213 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0092 | 0.2213 | 1 |
Echinococcus multilocularis | tyrosine kinase | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0113 | 0.3185 | 0.4267 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0139 | 0.4337 | 0.581 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0048 | 0.0188 | 0.0251 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0111 | 0.3102 | 0.4155 |
Brugia malayi | protein-tyrosine kinase | 0.0092 | 0.2213 | 0.1771 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0147 | 0.473 | 0.6337 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0207 | 0.7465 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0092 | 0.2213 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0092 | 0.2195 | 0.2941 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0111 | 0.3102 | 0.4155 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0115 | 0.3283 | 0.4398 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0092 | 0.2213 | 0.2069 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0092 | 0.2213 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0092 | 0.2213 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0147 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0147 | 0.473 | 0.6337 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0147 | 0.473 | 0.6337 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0092 | 0.2213 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0092 | 0.2213 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0147 | 0.473 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.8637 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0139 | 0.4337 | 0.581 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0129 | 0.3922 | 0.5254 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0092 | 0.2213 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0092 | 0.2213 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0139 | 0.4337 | 0.581 |
Onchocerca volvulus | 0.0092 | 0.2213 | 0.1888 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0147 | 0.473 | 0.6337 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0056 | 0.0571 | 0.0765 |
Onchocerca volvulus | 0.0092 | 0.2213 | 0.1888 | |
Onchocerca volvulus | Fatty acid synthase homolog | 0.025 | 0.9413 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0092 | 0.2195 | 0.2941 |
Mycobacterium ulcerans | thioesterase TesA | 0.0115 | 0.3283 | 0.4398 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0092 | 0.2213 | 0.2069 |
Brugia malayi | Protein kinase domain containing protein | 0.0092 | 0.2213 | 0.1771 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0092 | 0.2213 | 0.2069 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0092 | 0.2213 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0092 | 0.2213 | 0.1771 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0092 | 0.2213 | 0.2069 |
Schistosoma mansoni | tyrosine kinase | 0.0092 | 0.2213 | 1 |
Brugia malayi | hypothetical protein | 0.0092 | 0.2213 | 0.1771 |
Mycobacterium ulcerans | thioesterase | 0.0115 | 0.3283 | 0.4398 |
Loa Loa (eye worm) | acyl carrier protein | 0.0064 | 0.0922 | 0.0475 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0147 | 0.473 | 0.6337 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0092 | 0.2213 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0092 | 0.2213 | 0.2069 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2213 | 0.2069 |
Onchocerca volvulus | 0.0129 | 0.3922 | 0.3814 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0092 | 0.2213 | 0.2069 |
Brugia malayi | SH2 domain containing protein | 0.0092 | 0.2213 | 0.1771 |
Brugia malayi | Protein kinase domain containing protein | 0.0092 | 0.2213 | 0.1771 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0092 | 0.2213 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0092 | 0.2213 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0092 | 0.2213 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0092 | 0.2213 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0092 | 0.2213 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0129 | 0.3922 | 0.4179 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0139 | 0.4337 | 0.4016 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0092 | 0.2213 | 1 |
Brugia malayi | SRC-1 | 0.0092 | 0.2213 | 0.1771 |
Mycobacterium ulcerans | polyketide synthase | 0.0147 | 0.473 | 0.6337 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0092 | 0.2213 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0092 | 0.2213 | 1 |
Onchocerca volvulus | 0.0092 | 0.2213 | 0.1888 | |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0134 | 0.4144 | 0.5551 |
Brugia malayi | AMP-binding enzyme family protein | 0.0129 | 0.3922 | 0.3577 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.009 | 0.2116 | 0.2574 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0139 | 0.4337 | 0.581 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0092 | 0.2213 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0092 | 0.2213 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0092 | 0.2213 | 0.2069 |
Brugia malayi | SH2 domain containing protein | 0.0092 | 0.2213 | 0.1771 |
Onchocerca volvulus | 0.0241 | 0.9021 | 0.9557 | |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0092 | 0.2213 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0099 | 0.2515 | 0.3708 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1557 | 0.1259 |
Loa Loa (eye worm) | TK protein kinase | 0.0092 | 0.2213 | 0.2069 |
Schistosoma mansoni | tyrosine kinase | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0139 | 0.4337 | 0.581 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0092 | 0.2213 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0092 | 0.2195 | 0.2941 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0111 | 0.3102 | 0.4155 |
Echinococcus granulosus | tyrosine kinase | 0.0092 | 0.2213 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.01 | 0.2556 | 0.3424 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.