Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0062 | 0.0882 | 0.3708 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0131 | 0.2617 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0088 | 0.1521 | 0.581 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0088 | 0.1521 | 0.581 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0072 | 0.1119 | 0.5632 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0088 | 0.1521 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0058 | 0.077 | 0.2941 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0088 | 0.1521 | 0.581 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0082 | 0.1375 | 0.5254 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0072 | 0.1117 | 0.4267 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0088 | 0.1521 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0131 | 0.2617 | 1 |
Plasmodium falciparum | transporter, putative | 0.0072 | 0.1119 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.003 | 0.0066 | 0.0251 |
Onchocerca volvulus | 0.0423 | 1 | 1 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0085 | 0.1453 | 0.5551 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1119 | 0.0823 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0093 | 0.1658 | 0.6337 |
Plasmodium vivax | amine transporter, putative | 0.0072 | 0.1119 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0085 | 0.1453 | 0.5551 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1119 | 0.0823 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0035 | 0.02 | 0.0765 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0063 | 0.0896 | 0.3424 |
Mycobacterium ulcerans | polyketide synthase | 0.0088 | 0.1521 | 0.581 |
Echinococcus granulosus | serotonin transporter | 0.0423 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0082 | 0.1375 | 0.0288 |
Loa Loa (eye worm) | serotonin transporter b | 0.0423 | 1 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0073 | 0.1151 | 0.4398 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0093 | 0.1658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1119 | 0.0823 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1119 | 0.0823 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0072 | 0.1119 | 0.5 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0093 | 0.1658 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.0093 | 0.1658 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0058 | 0.077 | 0.2941 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0131 | 0.2617 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0088 | 0.1521 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0423 | 1 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0088 | 0.1521 | 0.581 |
Loa Loa (eye worm) | fatty acid synthase | 0.0086 | 0.1491 | 0.1207 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0093 | 0.1658 | 0.6337 |
Onchocerca volvulus | 0.0082 | 0.1375 | 0.0288 | |
Toxoplasma gondii | hypothetical protein | 0.0072 | 0.1119 | 0.5632 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0057 | 0.0742 | 0.2574 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.005 | 0.0564 | 0.2155 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0072 | 0.1119 | 0.5632 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0073 | 0.1151 | 0.4398 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.3028 | 0.2796 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0166 | 0.3506 | 0.2688 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0088 | 0.1521 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0093 | 0.1658 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0546 | 0.023 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.007 | 0.1088 | 0.4155 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0072 | 0.1119 | 0.0823 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0423 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0423 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1119 | 0.0823 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0072 | 0.1119 | 0.0823 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1119 | 0.0823 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0088 | 0.1521 | 0.0452 |
Toxoplasma gondii | hypothetical protein | 0.0072 | 0.1119 | 0.5632 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0093 | 0.1658 | 0.6337 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0423 | 1 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0093 | 0.1658 | 0.6337 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0423 | 1 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.007 | 0.1088 | 0.4155 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0072 | 0.1119 | 0.5632 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0093 | 0.1658 | 0.6337 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0093 | 0.1658 | 0.6337 |
Mycobacterium ulcerans | thioesterase TesA | 0.0073 | 0.1151 | 0.4398 |
Plasmodium falciparum | amino acid transporter, putative | 0.0072 | 0.1119 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 1 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.007 | 0.1088 | 0.4155 |
Mycobacterium ulcerans | thioesterase | 0.0073 | 0.1151 | 0.4398 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0158 | 0.33 | 0.2456 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1119 | 0.0823 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0423 | 1 | 1 |
Onchocerca volvulus | 0.0152 | 0.3163 | 0.2301 | |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0082 | 0.1375 | 0.1087 |
Plasmodium vivax | hypothetical protein, conserved | 0.0072 | 0.1119 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0058 | 0.077 | 0.2941 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0088 | 0.1521 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0131 | 0.2617 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.