Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ctsf protein | 0.0408 | 0.2489 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.1013 | 0.0045 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Onchocerca volvulus | 0.0408 | 0.2489 | 0.1718 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0408 | 0.2489 | 0.2489 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0569 | 0.4249 | 0.5698 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0184 | 0.0034 | 0.0046 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0569 | 0.4251 | 0.5725 |
Plasmodium vivax | vivapain-2 | 0.0408 | 0.2489 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0489 | 0.3377 | 0.4548 |
Mycobacterium ulcerans | polyketide synthase | 0.0569 | 0.4249 | 0.5722 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0408 | 0.2489 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0569 | 0.4249 | 0.5722 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.037 | 0.2074 | 0.2751 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0273 | 0.1013 | 0.1013 |
Onchocerca volvulus | 0.0408 | 0.2489 | 0.1718 | |
Loa Loa (eye worm) | cysteine protease | 0.0408 | 0.2489 | 0.1977 |
Brugia malayi | Cathepsin L-like precursor | 0.0408 | 0.2489 | 0.2489 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0273 | 0.1013 | 0.1013 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0605 | 0.4648 | 0.6238 |
Leishmania major | cathepsin L-like protease | 0.0408 | 0.2489 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.021 | 0.0325 | 0.0325 |
Loa Loa (eye worm) | fibroinase | 0.0408 | 0.2489 | 0.1977 |
Mycobacterium ulcerans | polyketide synthase | 0.0605 | 0.4648 | 0.626 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0859 | 0.7426 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0859 | 0.7426 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0859 | 0.7426 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0408 | 0.2489 | 0.1718 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0408 | 0.2489 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0408 | 0.2489 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0569 | 0.4249 | 0.5722 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0454 | 0.2994 | 0.4032 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.1013 | 0.0045 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0237 | 0.0623 | 0.0838 |
Leishmania major | cathepsin L-like protease | 0.0408 | 0.2489 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0408 | 0.2489 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0605 | 0.4648 | 0.6238 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0273 | 0.1013 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0273 | 0.1013 | 0.3182 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0569 | 0.4249 | 0.5722 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0462 | 0.3079 | 0.4146 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0569 | 0.4249 | 0.5722 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0408 | 0.2489 | 0.1977 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0569 | 0.4249 | 0.5722 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0408 | 0.2489 | 1 |
Onchocerca volvulus | 0.0408 | 0.2489 | 0.1718 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0408 | 0.2489 | 0.1718 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0968 | 0.8616 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0273 | 0.1013 | 0.1013 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0569 | 0.4249 | 0.5722 |
Onchocerca volvulus | Cathepsin F homolog | 0.0408 | 0.2489 | 0.1718 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0605 | 0.4648 | 0.626 |
Brugia malayi | AMP-binding enzyme family protein | 0.0548 | 0.4026 | 0.4026 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0408 | 0.2489 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0605 | 0.4648 | 0.626 |
Brugia malayi | Cathepsin L-like precursor | 0.0273 | 0.1013 | 0.1013 |
Onchocerca volvulus | 0.0408 | 0.2489 | 0.1718 | |
Echinococcus granulosus | cathepsin l1 | 0.0408 | 0.2489 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0605 | 0.4648 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0408 | 0.2489 | 1 |
Leishmania major | cathepsin L-like protease | 0.0408 | 0.2489 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0605 | 0.4648 | 0.626 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0489 | 0.3377 | 0.4548 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.021 | 0.0325 | 0.0325 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0859 | 0.7426 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0454 | 0.2994 | 0.3998 |
Brugia malayi | Cathepsin L-like precursor | 0.0408 | 0.2489 | 0.2489 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Leishmania major | cathepsin L-like protease | 0.0408 | 0.2489 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0408 | 0.2489 | 0.2489 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0408 | 0.2489 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0408 | 0.2489 | 1 |
Leishmania major | cathepsin L-like protease | 0.0408 | 0.2489 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0273 | 0.1013 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0408 | 0.2489 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0334 | 0.1677 | 0.2258 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1058 | 0.9603 | 1 |
Onchocerca volvulus | 0.0408 | 0.2489 | 0.1718 | |
Onchocerca volvulus | 0.0408 | 0.2489 | 0.1718 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0408 | 0.2489 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0489 | 0.3377 | 0.4517 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.1013 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0579 | 0.4362 | 0.4431 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0408 | 0.2489 | 0.1977 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0605 | 0.4648 | 0.6238 |
Onchocerca volvulus | 0.0408 | 0.2489 | 0.1718 | |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0184 | 0.0043 | 0.0058 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0408 | 0.2489 | 0.2489 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.037 | 0.2074 | 0.2793 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0548 | 0.4026 | 0.399 |
Leishmania major | cathepsin L-like protease | 0.0408 | 0.2489 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0381 | 0.2192 | 0.2726 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0408 | 0.2489 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0408 | 0.2489 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0605 | 0.4648 | 0.626 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0273 | 0.1013 | 0.3182 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0489 | 0.3377 | 0.4548 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0184 | 0.0043 | 0.0058 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0408 | 0.2489 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0569 | 0.4249 | 0.5698 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0273 | 0.1013 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Onchocerca volvulus | 0.0548 | 0.4026 | 0.3507 | |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1425 | 0.0584 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0569 | 0.4251 | 0.5725 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.037 | 0.2074 | 0.2793 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0605 | 0.4648 | 0.626 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0408 | 0.2489 | 0.2489 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0273 | 0.1013 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0408 | 0.2489 | 0.2489 |
Leishmania major | cathepsin L-like protease | 0.0408 | 0.2489 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0548 | 0.4026 | 0.5422 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0569 | 0.4249 | 0.4249 |
Plasmodium vivax | vivapain-2 | 0.0408 | 0.2489 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0408 | 0.2489 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0408 | 0.2489 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0408 | 0.2489 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0422 | 0.2639 | 0.3554 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0454 | 0.2994 | 0.4032 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.2489 | 0.1977 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0569 | 0.4249 | 0.5722 |
Echinococcus multilocularis | cysteine protease | 0.0408 | 0.2489 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0408 | 0.2489 | 0.3605 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0418 | 0.2597 | 0.3927 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0408 | 0.2489 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0408 | 0.2489 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0408 | 0.2489 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0408 | 0.2489 | 1 |
Onchocerca volvulus | 0.1021 | 0.9204 | 0.9536 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0408 | 0.2489 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0408 | 0.2489 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0408 | 0.2489 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.