Detailed information for compound 1759958

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 716.886 | Formula: C39H48N4O7S
  • H donors: 3 H acceptors: 5 LogP: 5.75 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H](N1C[C@H](C)[C@@H](OCCCC[C@H](Oc2c(C1=O)cc(cc2)NS(=O)(=O)c1ccccc1)C)CN(C(=O)Nc1cccc2c1cccc2)C)C
  • InChi: 1S/C39H48N4O7S/c1-27-24-43(28(2)26-44)38(45)34-23-31(41-51(47,48)32-16-6-5-7-17-32)20-21-36(34)50-29(3)13-10-11-22-49-37(27)25-42(4)39(46)40-35-19-12-15-30-14-8-9-18-33(30)35/h5-9,12,14-21,23,27-29,37,41,44H,10-11,13,22,24-26H2,1-4H3,(H,40,46)/t27-,28+,29+,37-/m0/s1
  • InChiKey: MDXCNNUEDCXFGI-MZXQNBQBSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus SH2 motif 0.0265 0.1665 0.1098
Echinococcus granulosus tyrosine protein kinase Btk29A 0.017 0.0642 0.0005
Brugia malayi SH2 domain containing protein 0.0265 0.1665 0.3578
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.0435 0.3501 0.3501
Trichomonas vaginalis protein tyrosine kinase, putative 0.017 0.0642 0.5
Schistosoma mansoni nck2/grb4 0.0265 0.1665 0.1093
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0265 0.1662 1
Echinococcus multilocularis protein kinase 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0265 0.1665 0.3578
Schistosoma mansoni SH2A 0.0265 0.1665 0.1093
Echinococcus multilocularis sodium:myo inositol cotransporter 0.1038 1 1
Echinococcus granulosus SH2 domain containing protein 7 0.0265 0.1665 0.1098
Schistosoma mansoni hypothetical protein 0.0265 0.1665 0.1093
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Trypanosoma cruzi protein kinase, putative 0.017 0.0642 0.5
Brugia malayi protein-tyrosine kinase 0.0435 0.3501 1
Echinococcus multilocularis tyrosine kinase 0.017 0.0642 0.0642
Echinococcus granulosus kinase suppressor of Ras 1 0.017 0.0642 0.0005
Echinococcus multilocularis insulin receptor 0.017 0.0642 0.0642
Echinococcus granulosus tyrosine protein kinase csk 0.017 0.0642 0.0005
Echinococcus granulosus integrin linked protein kinase 0.017 0.0642 0.0005
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0435 0.3501 0.3059
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0265 0.1665 0.1665
Brugia malayi SH2 domain containing protein 0.0265 0.1665 0.3578
Echinococcus multilocularis SH2 motif 0.0265 0.1665 0.1665
Onchocerca volvulus 0.0265 0.1665 0.3578
Echinococcus multilocularis integrin linked protein kinase 0.017 0.0642 0.0642
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0265 0.1665 0.1665
Echinococcus multilocularis protein KINase family member (kin 25) 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Plasmodium falciparum protein kinase, putative 0.017 0.0642 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.3501 1
Schistosoma mansoni tyrosine kinase 0.0435 0.3501 0.3055
Trichomonas vaginalis STE family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Brugia malayi Protein kinase domain containing protein 0.0435 0.3501 1
Onchocerca volvulus 0.0265 0.1662 0.3568
Brugia malayi SH2 domain containing protein 0.0265 0.1665 0.3578
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.017 0.0642 0.0005
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.017 0.0642 0.5
Brugia malayi Variant SH3 domain containing protein 0.0265 0.1665 0.3578
Brugia malayi hypothetical protein 0.0265 0.1665 0.3578
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.3501 1
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.017 0.0637 0.0637
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.017 0.0642 0.0005
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Loa Loa (eye worm) hypothetical protein 0.0265 0.1662 0.3568
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis N chimaerin 0.0265 0.1665 0.1665
Loa Loa (eye worm) STAT protein 0.0265 0.1665 0.3578
Schistosoma mansoni inositol transporter 0.1038 1 1
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0265 0.1665 0.1093
Echinococcus granulosus retinal guanylyl cyclase 2 0.017 0.0642 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.3501 1
Brugia malayi Sex muscle abnormal protein 5 0.0265 0.1665 0.3578
Echinococcus multilocularis SH2 motif 0.0265 0.1665 0.1665
Brugia malayi Variant SH3 domain containing protein 0.0265 0.1665 0.3578
Schistosoma mansoni tensin 0.0265 0.1665 0.1093
Echinococcus multilocularis tyrosine protein kinase csk 0.017 0.0642 0.0642
Echinococcus multilocularis growth factor receptor bound protein 2 0.0265 0.1665 0.1665
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0265 0.1665 0.1093
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0265 0.1665 0.1098
Brugia malayi Variant SH3 domain containing protein 0.0265 0.1665 0.3578
Brugia malayi Sodium:solute symporter family protein 0.0265 0.1662 0.3568
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0265 0.1665 0.3578
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.0435 0.3501 0.3059
Echinococcus granulosus tyrosine protein kinase Fyn 0.0435 0.3501 0.3059
Brugia malayi Pax transcription factor protein 2 0.0291 0.1941 0.4543
Echinococcus granulosus insulin receptor 0.017 0.0642 0.0005
Echinococcus multilocularis retinal guanylyl cyclase 2 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0943 0.898 0.898
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0435 0.3501 0.3055
Entamoeba histolytica SH2 domain containing protein 0.0265 0.1665 0.3578
Brugia malayi Protein kinase domain containing protein 0.0435 0.3501 1
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Brugia malayi SRC-1 0.0435 0.3501 1
Echinococcus granulosus tyrosine protein kinase csk 0.017 0.0642 0.0005
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.017 0.0642 0.0005
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0265 0.1665 0.1098
Schistosoma mansoni tensin-related 0.0265 0.1665 0.1093
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0265 0.1665 0.1665
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus solute carrier family 5 0.1038 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0265 0.1665 0.3578
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Onchocerca volvulus 0.0265 0.1665 0.3578
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0642 0.5
Echinococcus multilocularis tensin 0.0265 0.1665 0.1665
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0642 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.017 0.0642 0.0005
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis activated cdc42 kinase 1 0.017 0.0642 0.0642
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.017 0.0642 0.0005
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus epidermal growth factor receptor 0.017 0.0642 0.0005
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0435 0.3501 0.3501
Brugia malayi Protein kinase domain containing protein 0.0435 0.3501 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0435 0.3501 0.3059
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0265 0.1665 0.1665
Loa Loa (eye worm) SH2 domain-containing protein 0.0265 0.1665 0.3578
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0265 0.1665 0.1665
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0435 0.3501 0.3501
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.017 0.0642 0.0005
Echinococcus granulosus tyrosine protein kinase Lyn 0.0435 0.3501 0.3059
Echinococcus granulosus hypothetical protein 0.0265 0.1665 0.1098
Schistosoma mansoni adapter molecule crk 0.0265 0.1665 0.1093
Echinococcus multilocularis tyrosine protein kinase Srms 0.0435 0.3501 0.3501
Echinococcus granulosus tyrosine protein kinase ABL1 0.0435 0.3501 0.3059
Echinococcus multilocularis SH2 motif 0.0265 0.1665 0.1665
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.3501 1
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trypanosoma brucei Pseudokinase, putative 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus activin receptor type 0.017 0.0642 0.0005
Schistosoma mansoni GTPase activating protein 0.0265 0.1665 0.1093
Echinococcus granulosus tyrosine protein kinase shark 0.0435 0.3501 0.3059
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.3501 1
Schistosoma mansoni hypothetical protein 0.0265 0.1665 0.1093
Echinococcus granulosus tyrosine protein kinase 0.017 0.0642 0.0005
Echinococcus granulosus tensin 0.0265 0.1665 0.1098
Brugia malayi SH2 domain containing protein 0.0265 0.1665 0.3578
Onchocerca volvulus 0.0435 0.3501 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.1038 1 1
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0265 0.1662 0.1095
Echinococcus multilocularis tensin 0.0265 0.1665 0.1665
Echinococcus multilocularis activin receptor type 0.017 0.0642 0.0642
Brugia malayi SH2 domain containing protein 0.0265 0.1665 0.3578
Trichomonas vaginalis TK family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0435 0.3501 0.3501
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.017 0.0642 0.5
Echinococcus multilocularis SHC transforming protein 3 0.0265 0.1665 0.1665
Giardia lamblia Kinase, NEK 0.017 0.0642 0.5
Schistosoma mansoni tyrosine kinase 0.0435 0.3501 0.3055
Schistosoma mansoni suppressor of cytokine signaling 0.0265 0.1665 0.1093
Loa Loa (eye worm) SRC-1 0.0435 0.3501 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0265 0.1665 0.1665
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0265 0.1665 0.3578
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0435 0.3501 0.3501
Echinococcus granulosus tyrosine protein kinase Fyn 0.0435 0.3501 0.3059
Schistosoma mansoni tyrosine kinase 0.0435 0.3501 0.3055
Echinococcus multilocularis heat shock protein 70 0.017 0.0642 0.0642
Echinococcus multilocularis tyrosine protein kinase csk 0.017 0.0642 0.0642
Echinococcus multilocularis c src tyrosine kinase 0.0435 0.3501 0.3501
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0265 0.1665 0.3578
Onchocerca volvulus 0.0435 0.3501 1
Entamoeba histolytica protein kinase, putative 0.0265 0.1665 0.3578
Echinococcus granulosus signal transduction protein lnk realted 0.0265 0.1665 0.1098
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.017 0.0642 0.0642
Brugia malayi Variant SH3 domain containing protein 0.0265 0.1665 0.3578
Schistosoma mansoni growth factor receptor-bound protein 0.0265 0.1665 0.1093
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0265 0.1662 0.1662
Echinococcus granulosus NCK adaptor protein 0.0265 0.1665 0.1098
Loa Loa (eye worm) SH2 domain-containing protein 0.0265 0.1665 0.3578
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus protein tyrosine kinase 0.017 0.0642 0.0005
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Echinococcus multilocularis tyrosine kinase 0.0435 0.3501 0.3501
Echinococcus multilocularis tyrosine protein kinase HCK 0.017 0.0642 0.0642
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0265 0.1665 0.1093
Echinococcus granulosus tyrosine protein kinase Src42A 0.0265 0.1665 0.1098
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0265 0.1665 0.1098
Brugia malayi SH2 domain containing protein 0.0265 0.1665 0.3578
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus SH2 motif 0.0265 0.1665 0.1098
Plasmodium falciparum tyrosine kinase-like protein 0.017 0.0642 0.5
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.017 0.0642 0.0642
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.1941 0.4543
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.017 0.0642 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.3501 1
Schistosoma mansoni high-affinity choline transporter 0.0265 0.1662 0.109
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.3501 1
Echinococcus granulosus tyrosine kinase 0.0435 0.3501 0.3059
Giardia lamblia Kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Schistosoma mansoni sodium/solute symporter 0.0265 0.1662 0.109
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Plasmodium falciparum protein kinase, putative 0.017 0.0642 0.5
Echinococcus granulosus tyrosine protein kinase pr2 0.017 0.0642 0.0005
Trichomonas vaginalis AGC family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis fibroblast growth factor receptor 4 0.017 0.0642 0.0642
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis protein kinase 0.017 0.0642 0.0642
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0435 0.3501 0.3059
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0435 0.3501 0.3501
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0265 0.1665 0.1665
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein kinase 0.017 0.0642 0.0642
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0265 0.1665 0.3578
Brugia malayi Protein kinase domain containing protein 0.0435 0.3501 1
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0435 0.3501 0.3059
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0435 0.3501 1
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.3501 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.017 0.0642 0.0005
Echinococcus granulosus tyrosine protein kinase HCK 0.017 0.0642 0.0005
Echinococcus multilocularis natriuretic peptide receptor 1 0.017 0.0642 0.0642
Giardia lamblia Kinase, NEK 0.017 0.0642 0.5
Echinococcus multilocularis NCK adaptor protein 0.0265 0.1665 0.1665
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0265 0.1665 0.1093
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0435 0.3501 0.3501
Onchocerca volvulus 0.0435 0.3501 1
Onchocerca volvulus 0.0265 0.1665 0.3578
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0642 0.5
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein kinase shark 0.0435 0.3501 0.3501
Echinococcus granulosus activated cdc42 kinase 1 0.017 0.0642 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.3501 1
Onchocerca volvulus 0.0265 0.1665 0.3578
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.3501 1
Echinococcus multilocularis protein tyrosine kinase 0.017 0.0642 0.0642
Echinococcus granulosus epidermal growth factor receptor 0.017 0.0642 0.0005
Brugia malayi hypothetical protein 0.0435 0.3501 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0265 0.1665 0.3578
Schistosoma mansoni tyrosine kinase 0.0435 0.3501 0.3055
Echinococcus granulosus high affinity choline transporter 1 0.0265 0.1662 0.1095
Plasmodium vivax tyrosine kinase-like protein, putative 0.017 0.0642 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0265 0.1665 0.1093
Schistosoma mansoni tensin 0.0265 0.1665 0.1093
Plasmodium falciparum protein kinase, putative 0.017 0.0642 0.5
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0642 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.017 0.0642 0.0642
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0265 0.1665 0.1098
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0265 0.1665 0.1093
Brugia malayi SH2 domain containing protein 0.0435 0.3501 1
Plasmodium vivax protein kinase, putative 0.017 0.0642 0.5
Echinococcus multilocularis 0.0265 0.1665 0.1665
Echinococcus granulosus c src tyrosine kinase 0.0435 0.3501 0.3059
Brugia malayi STAT protein, DNA binding domain containing protein 0.0265 0.1665 0.3578
Trypanosoma brucei protein kinase, putative 0.017 0.0642 0.5
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0265 0.1665 0.3578
Echinococcus granulosus SH2 domain containing adapter protein F 0.0265 0.1665 0.1098
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0435 0.3501 0.3501
Echinococcus granulosus ephrin type A receptor 4 A 0.017 0.0642 0.0005
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0435 0.3501 0.3501
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus tyrosine kinase 0.017 0.0642 0.0005
Echinococcus multilocularis ephrin type A receptor 4 A 0.017 0.0642 0.0642
Echinococcus granulosus growth factor receptor bound protein 2 0.0265 0.1665 0.1098
Trichomonas vaginalis protein kinase atn1, putative 0.017 0.0642 0.5
Onchocerca volvulus 0.0291 0.1941 0.4543
Onchocerca volvulus 0.0265 0.1665 0.3578
Brugia malayi Tensin 0.0265 0.1665 0.3578
Trypanosoma brucei Flagellum attachment zone protein 20 0.017 0.0642 0.5
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0265 0.1665 0.3578
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0265 0.1665 0.1665
Echinococcus multilocularis solute carrier family 28 0.017 0.0637 0.0637
Giardia lamblia Protein 21.1 0.017 0.0642 0.5
Echinococcus granulosus SHC transforming protein 3 0.0265 0.1665 0.1098
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Schistosoma mansoni tyrosine kinase 0.0435 0.3501 0.3055
Echinococcus granulosus fibroblast growth factor receptor 4 0.017 0.0642 0.0005
Echinococcus multilocularis transfer RNA-Thr 0.017 0.0642 0.0642
Trypanosoma cruzi protein kinase, putative 0.017 0.0642 0.5
Echinococcus multilocularis FL cytokine receptor 0.017 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Echinococcus multilocularis solute carrier family 5 0.1038 1 1
Echinococcus granulosus receptor type guanylyl cyclase 0.017 0.0642 0.0005
Echinococcus multilocularis tyrosine protein kinase pr2 0.017 0.0642 0.0642
Echinococcus granulosus tyrosine protein kinase csk 0.017 0.0642 0.0005
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Echinococcus granulosus dual specificity testis-specific protein kinase 0.017 0.0642 0.0005
Echinococcus multilocularis tyrosine protein kinase Abl 0.0435 0.3501 0.3501
Trichomonas vaginalis serine-threonine protein kinase, putative 0.017 0.0642 0.5
Leishmania major protein kinase, putative 0.017 0.0642 0.5
Schistosoma mansoni shc transforming protein 0.0265 0.1665 0.1093
Echinococcus granulosus tyrosine protein kinase Src42A 0.0435 0.3501 0.3059
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Echinococcus multilocularis receptor type guanylyl cyclase 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.017 0.0642 0.0005
Echinococcus granulosus N chimaerin 0.0265 0.1665 0.1098
Leishmania major protein kinase, putative 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0435 0.3501 0.3501
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.0435 0.3501 1
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Brugia malayi tRNA modification GTPase TrmE family protein 0.0265 0.1665 0.3578
Onchocerca volvulus 0.0435 0.3501 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0435 0.3501 0.3501
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Loa Loa (eye worm) hypothetical protein 0.0265 0.1662 0.3568
Echinococcus granulosus raf serine:threonine protein kinase 0.017 0.0642 0.0005
Onchocerca volvulus 0.0265 0.1665 0.3578
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Echinococcus multilocularis dual specificity testis specific protein kinase 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Loa Loa (eye worm) hypothetical protein 0.0435 0.3501 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.0265 0.1665 0.1098
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0265 0.1665 0.1093
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Schistosoma mansoni tensin-related 0.0265 0.1665 0.1093
Echinococcus multilocularis SH2 domain containing protein 7 0.0265 0.1665 0.1665
Echinococcus multilocularis raf serine:threonine protein kinase 0.017 0.0642 0.0642
Loa Loa (eye worm) TK protein kinase 0.0435 0.3501 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus natriuretic peptide receptor 1 0.017 0.0642 0.0005
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0435 0.3501 0.3501
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Onchocerca volvulus 0.0435 0.3501 1
Brugia malayi SH2 domain containing protein 0.0265 0.1665 0.3578
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus insulin growth factor 1 receptor beta 0.017 0.0642 0.0005
Echinococcus granulosus sodium:myo inositol cotransporter 0.1038 1 1
Brugia malayi RhoGAP domain containing protein 0.0265 0.1665 0.3578
Echinococcus multilocularis high affinity choline transporter 1 0.0265 0.1662 0.1662
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.017 0.0642 0.5
Brugia malayi Tyrosine-protein kinase abl-1 0.0435 0.3501 1
Plasmodium falciparum tyrosine kinase-like protein 0.017 0.0642 0.5
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Schistosoma mansoni tyrosine kinase 0.0435 0.3501 0.3055
Echinococcus granulosus tyrosine protein kinase Src64B 0.0435 0.3501 0.3059
Schistosoma mansoni tensin 0.0265 0.1665 0.1093
Onchocerca volvulus 0.0435 0.3501 1
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Brugia malayi GH02984p 0.0265 0.1662 0.3568
Echinococcus granulosus retinal guanylyl cyclase 2 0.017 0.0642 0.0005
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0435 0.3501 0.3501
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.017 0.0642 0.0642
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0265 0.1665 0.1098
Schistosoma mansoni inositol transporter 0.1038 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0265 0.1665 0.3578
Brugia malayi SH2 domain containing protein 0.0435 0.3501 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.017 0.0642 0.0642
Plasmodium vivax tyrosine kinase-like protein, putative 0.017 0.0642 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.017 0.0642 0.0642
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0265 0.1665 0.1093
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.0435 0.3501 0.3059
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.017 0.0642 0.0005
Schistosoma mansoni vav2 0.0265 0.1665 0.1093
Brugia malayi Protein kinase domain containing protein 0.0435 0.3501 1
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus protein kinase 0.017 0.0642 0.0005
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.017 0.0642 0.0005
Echinococcus granulosus tyrosine kinase 0.0435 0.3501 0.3059
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0435 0.3501 0.3501
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.017 0.0642 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0435 0.3501 0.3059
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0265 0.1665 0.1665
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0265 0.1665 0.3578
Leishmania major hypothetical protein, conserved 0.017 0.0642 0.5
Echinococcus multilocularis signal transduction protein lnk realted 0.0265 0.1665 0.1665
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0435 0.3501 0.3059
Echinococcus granulosus suppressor of cytokine signaling 7 0.0265 0.1665 0.1098
Echinococcus granulosus sodium:glucose cotransporter 2 0.1038 1 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.017 0.0642 0.0642
Echinococcus granulosus expressed conserved protein 0.0265 0.1665 0.1098
Loa Loa (eye worm) hypothetical protein 0.0265 0.1665 0.3578
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.017 0.0642 0.0005
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.017 0.0642 0.0642
Trichomonas vaginalis TKL family protein kinase 0.017 0.0642 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0265 0.1665 0.3578

Activities

Activity type Activity value Assay description Source Reference
AbsAC40 (functional) = 14.15 uM PubChem BioAssay. HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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