Detailed information for compound 1760406

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 322.318 | Formula: C17H14N4O3
  • H donors: 1 H acceptors: 4 LogP: 2.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cccc(c1)n1nnc(c1)C(=O)c1ccccc1N
  • InChi: 1S/C17H14N4O3/c1-24-17(23)11-5-4-6-12(9-11)21-10-15(19-20-21)16(22)13-7-2-3-8-14(13)18/h2-10H,18H2,1H3
  • InChiKey: KLIYPADIEDQSSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen-related receptor alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Steroid receptor seven-up type 2 estrogen-related receptor alpha 423 aa 358 aa 29.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Loa Loa (eye worm) TK/FER protein kinase 0.1807 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.104 0.4139 0.4139
Onchocerca volvulus 0.0767 0.2051 0.1144
Loa Loa (eye worm) TK/FER protein kinase 0.104 0.4139 0.409
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Loa Loa (eye worm) TK/FER protein kinase 0.1807 1 1
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Echinococcus granulosus retinal guanylyl cyclase 2 0.104 0.4139 0.4139
Echinococcus multilocularis growth factor receptor bound protein 2 0.0767 0.2051 0.2051
Trichomonas vaginalis serine-threonine protein kinase, putative 0.104 0.4139 0.5
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Echinococcus granulosus SH2 domain containing protein 7 0.0767 0.2051 0.2051
Entamoeba histolytica receptor protein kinase, putative 0.104 0.4139 0.2627
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0767 0.2051 0.1985
Trypanosoma cruzi protein kinase, putative 0.104 0.4139 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Echinococcus granulosus insulin growth factor 1 receptor beta 0.104 0.4139 0.4139
Brugia malayi Tyrosine-protein kinase abl-1 0.1807 1 1
Trichomonas vaginalis conserved hypothetical protein 0.104 0.4139 0.5
Echinococcus multilocularis NCK adaptor protein 0.0767 0.2051 0.2051
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Loa Loa (eye worm) TK/FER protein kinase 0.1807 1 1
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Schistosoma mansoni hypothetical protein 0.0767 0.2051 0.1985
Schistosoma mansoni tyrosine kinase 0.1807 1 1
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Echinococcus granulosus integrin linked protein kinase 0.104 0.4139 0.4139
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.104 0.4139 0.2627
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1807 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0767 0.2051 0.2051
Echinococcus multilocularis SH2 motif 0.0767 0.2051 0.2051
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Loa Loa (eye worm) protein kinase domain-containing protein 0.104 0.4139 0.409
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Brugia malayi bone morphogenetic protein type 1 receptor 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0795 0.2262 0.2199
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.1261 0.5827 0.5827
Loa Loa (eye worm) TK protein kinase 0.104 0.4139 0.409
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Onchocerca volvulus 0.1807 1 1
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Echinococcus multilocularis SHC transforming protein 3 0.0767 0.2051 0.2051
Loa Loa (eye worm) TK/KIN6 protein kinase 0.104 0.4139 0.409
Trichomonas vaginalis AGC family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.104 0.4139 0.347
Brugia malayi Furin-like cysteine rich region family protein 0.104 0.4139 0.2627
Giardia lamblia Kinase, NEK 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.104 0.4139 0.4139
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Trichomonas vaginalis CAMK family protein kinase 0.104 0.4139 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.104 0.4139 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.1807 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1807 1 1
Brugia malayi integrin-linked kinase 0.104 0.4139 0.2627
Brugia malayi Probable tyrosine-protein kinase kin-31 0.104 0.4139 0.2627
Echinococcus multilocularis natriuretic peptide receptor 1 0.104 0.4139 0.4139
Echinococcus multilocularis kinase suppressor of Ras 1 0.104 0.4139 0.4139
Schistosoma mansoni tensin 0.0767 0.2051 0.1985
Entamoeba histolytica tyrosin kinase, putative 0.104 0.4139 0.2627
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Loa Loa (eye worm) SH2 domain-containing protein 0.0767 0.2051 0.1985
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0767 0.2051 0.2051
Brugia malayi C-terminal src kinase protein 1 0.104 0.4139 0.2627
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Loa Loa (eye worm) TK/EGFR protein kinase 0.104 0.4139 0.409
Schistosoma mansoni signal transduction protein lnk-related 0.0767 0.2051 0.1985
Onchocerca volvulus 0.0767 0.2051 0.1144
Echinococcus multilocularis protein KINase family member (kin 25) 0.104 0.4139 0.4139
Brugia malayi ephrin receptor 1 precursor 0.104 0.4139 0.2627
Echinococcus granulosus suppressor of cytokine signaling 6 0.0767 0.2051 0.2051
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1807 1 1
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Trichomonas vaginalis conserved hypothetical protein 0.104 0.4139 0.5
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus granulosus protein tyrosine kinase 0.104 0.4139 0.4139
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.104 0.4139 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.0767 0.2051 0.1985
Leishmania major hypothetical protein, conserved 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus granulosus tyrosine kinase 0.1807 1 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1807 1 1
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Entamoeba histolytica hypothetical protein, conserved 0.104 0.4139 0.2627
Onchocerca volvulus 0.1807 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Echinococcus granulosus tyrosine protein kinase Lyn 0.1807 1 1
Echinococcus multilocularis c src tyrosine kinase 0.1807 1 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.104 0.4139 0.4139
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1807 1 1
Loa Loa (eye worm) SRC-1 0.1807 1 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.104 0.4139 0.4139
Echinococcus granulosus tyrosine protein kinase Blk 0.1807 1 1
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Schistosoma mansoni tensin 0.0767 0.2051 0.1985
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.104 0.4139 0.2627
Entamoeba histolytica ankyrin repeat protein 0.104 0.4139 0.2627
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0767 0.2051 0.2051
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1807 1 1
Toxoplasma gondii STE kinase 0.104 0.4139 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.104 0.4139 0.4139
Loa Loa (eye worm) RGC/RGC protein kinase 0.104 0.4139 0.409
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0767 0.2051 0.2051
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Echinococcus multilocularis retinal guanylyl cyclase 2 0.104 0.4139 0.4139
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.104 0.4139 0.409
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Loa Loa (eye worm) TK protein kinase 0.104 0.4139 0.409
Echinococcus multilocularis tyrosine kinase 0.104 0.4139 0.4139
Echinococcus multilocularis tyrosine protein kinase csk 0.104 0.4139 0.4139
Toxoplasma gondii protein kinase 0.104 0.4139 0.5
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0767 0.2051 0.1144
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis tyrosine kinase 0.1807 1 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.104 0.4139 0.4139
Brugia malayi Immunoglobulin I-set domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.104 0.4139 0.4139
Onchocerca volvulus 0.104 0.4139 0.347
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Trichomonas vaginalis conserved hypothetical protein 0.104 0.4139 0.5
Entamoeba histolytica ankyrin repeat protein 0.104 0.4139 0.2627
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) TK/FAK protein kinase 0.104 0.4139 0.409
Echinococcus granulosus c src tyrosine kinase 0.1807 1 1
Echinococcus multilocularis adam 17 protease 0.0795 0.2262 0.2262
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.104 0.4139 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.1807 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.104 0.4139 0.4139
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0767 0.2051 0.1985
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.104 0.4139 0.409
Plasmodium falciparum tyrosine kinase-like protein 0.104 0.4139 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.1807 1 1
Echinococcus multilocularis tensin 0.0767 0.2051 0.2051
Schistosoma mansoni hypothetical protein 0.104 0.4139 0.409
Trypanosoma brucei Pseudokinase, putative 0.104 0.4139 0.5
Echinococcus multilocularis tensin 0.0767 0.2051 0.2051
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.104 0.4139 0.4139
Brugia malayi Guanylyl cyclase protein 23 0.104 0.4139 0.2627
Onchocerca volvulus 0.104 0.4139 0.347
Echinococcus granulosus raf serine:threonine protein kinase 0.104 0.4139 0.4139
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.104 0.4139 0.5
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.104 0.4139 0.409
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1807 1 1
Trichomonas vaginalis STE family protein kinase 0.104 0.4139 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.104 0.4139 0.4139
Echinococcus multilocularis raf serine:threonine protein kinase 0.104 0.4139 0.4139
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1807 1 1
Loa Loa (eye worm) TK/ACK protein kinase 0.104 0.4139 0.409
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.104 0.4139 0.4139
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.104 0.4139 0.409
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.104 0.4139 0.4139
Echinococcus granulosus tyrosine protein kinase 0.104 0.4139 0.4139
Trypanosoma brucei protein kinase, putative 0.104 0.4139 0.5
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0767 0.2051 0.2051
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) TK/FER protein kinase 0.1807 1 1
Loa Loa (eye worm) TK protein kinase 0.104 0.4139 0.409
Trichomonas vaginalis protein tyrosine kinase, putative 0.104 0.4139 0.5
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus granulosus tyrosine protein kinase ABL1 0.1807 1 1
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Brugia malayi protein-tyrosine kinase 0.1807 1 1
Onchocerca volvulus 0.0767 0.2051 0.1144
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Brugia malayi SRC-1 0.1807 1 1
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0767 0.2051 0.1985
Echinococcus multilocularis tyrosine protein kinase csk 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0767 0.2051 0.1985
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0767 0.2051 0.1985
Echinococcus multilocularis tyrosine protein kinase HCK 0.104 0.4139 0.4139
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) TK protein kinase 0.104 0.4139 0.409
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1261 0.5827 0.5827
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Loa Loa (eye worm) TK/EPH protein kinase 0.104 0.4139 0.409
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Echinococcus granulosus tyrosine protein kinase shark 0.1807 1 1
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis 0.0767 0.2051 0.2051
Brugia malayi Protein kinase domain containing protein 0.1807 1 1
Schistosoma mansoni serine/threonine protein kinase 0.104 0.4139 0.409
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.104 0.4139 0.2627
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1807 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0767 0.2051 0.2051
Echinococcus granulosus tyrosine protein kinase Src42A 0.0767 0.2051 0.2051
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.104 0.4139 0.409
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) TK/ROR protein kinase 0.104 0.4139 0.409
Loa Loa (eye worm) TK/ALK protein kinase 0.104 0.4139 0.409
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.104 0.4139 0.4139
Loa Loa (eye worm) matrixin family protein 0.0914 0.3172 0.3116
Brugia malayi SH2 domain containing protein 0.1807 1 1
Schistosoma mansoni tyrosine kinase 0.1807 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.104 0.4139 0.409
Schistosoma mansoni tyrosine protein kinase 0.104 0.4139 0.409
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.104 0.4139 0.4139
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Schistosoma mansoni tensin 0.0767 0.2051 0.1985
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.104 0.4139 0.2627
Onchocerca volvulus 0.0767 0.2051 0.1144
Leishmania major protein kinase, putative 0.104 0.4139 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.1807 1 1
Echinococcus granulosus signal transduction protein lnk realted 0.0767 0.2051 0.2051
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1807 1 1
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Brugia malayi Probable tyrosine-protein kinase kin-31 0.104 0.4139 0.2627
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0767 0.2051 0.2051
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.104 0.4139 0.4139
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Onchocerca volvulus 0.1807 1 1
Echinococcus multilocularis integrin linked protein kinase 0.104 0.4139 0.4139
Schistosoma mansoni tyrosine-protein kinase fps85d 0.104 0.4139 0.409
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Loa Loa (eye worm) TK/RYK protein kinase 0.104 0.4139 0.409
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis signal transduction protein lnk realted 0.0767 0.2051 0.2051
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus granulosus SHC transforming protein 3 0.0767 0.2051 0.2051
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0767 0.2051 0.2051
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Echinococcus granulosus activin receptor type 0.104 0.4139 0.4139
Onchocerca volvulus Tyrosine kinase homolog 0.104 0.4139 0.347
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.1807 1 1
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni serine/threonine RGC 0.104 0.4139 0.409
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Schistosoma mansoni GTPase activating protein 0.0767 0.2051 0.1985
Trichomonas vaginalis TK family protein kinase 0.104 0.4139 0.5
Plasmodium vivax protein kinase, putative 0.104 0.4139 0.5
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) TK protein kinase 0.104 0.4139 0.409
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1807 1 1
Schistosoma mansoni protein tyrosine kinase 0.104 0.4139 0.409
Brugia malayi SH2 domain containing protein 0.1807 1 1
Echinococcus granulosus ephrin type A receptor 4 A 0.104 0.4139 0.4139
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.104 0.4139 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.104 0.4139 0.2627
Loa Loa (eye worm) TK/FER protein kinase 0.104 0.4139 0.409
Schistosoma mansoni ephrin receptor 0.104 0.4139 0.409
Echinococcus granulosus activated cdc42 kinase 1 0.104 0.4139 0.4139
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Echinococcus multilocularis activated cdc42 kinase 1 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Onchocerca volvulus 0.104 0.4139 0.347
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.104 0.4139 0.4139
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0767 0.2051 0.1985
Loa Loa (eye worm) TK/FER protein kinase 0.104 0.4139 0.409
Onchocerca volvulus Matrilysin homolog 0.0857 0.2737 0.1908
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1807 1 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.104 0.4139 0.4139
Echinococcus granulosus epidermal growth factor receptor 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Loa Loa (eye worm) hypothetical protein 0.1807 1 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0767 0.2051 0.2051
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Loa Loa (eye worm) STAT protein 0.0767 0.2051 0.1985
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Onchocerca volvulus 0.104 0.4139 0.347
Leishmania major protein kinase, putative 0.104 0.4139 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.104 0.4139 0.2627
Brugia malayi hypothetical protein 0.1807 1 1
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus granulosus tyrosine protein kinase Fyn 0.1807 1 1
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus granulosus SH2 motif 0.0767 0.2051 0.2051
Onchocerca volvulus 0.1807 1 1
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Entamoeba histolytica serine/threonine kinase, putative 0.104 0.4139 0.2627
Echinococcus multilocularis tyrosine protein kinase Srms 0.1807 1 1
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Echinococcus granulosus insulin receptor 0.104 0.4139 0.4139
Trypanosoma cruzi protein kinase, putative 0.104 0.4139 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.104 0.4139 0.5
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus multilocularis retinal guanylyl cyclase 2 0.104 0.4139 0.4139
Plasmodium falciparum protein kinase, putative 0.104 0.4139 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0767 0.2051 0.1985
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0767 0.2051 0.1985
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0767 0.2051 0.1144
Plasmodium falciparum tyrosine kinase-like protein 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus granulosus dual specificity testis-specific protein kinase 0.104 0.4139 0.4139
Entamoeba histolytica tyrosin kinase, putative 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Entamoeba histolytica serine/threonine kinase, putative 0.104 0.4139 0.2627
Echinococcus multilocularis SH2 domain containing protein 7 0.0767 0.2051 0.2051
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Loa Loa (eye worm) TK protein kinase 0.104 0.4139 0.409
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.104 0.4139 0.4139
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.1807 1 1
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Giardia lamblia Kinase 0.104 0.4139 0.5
Schistosoma mansoni src-type protein tyrosine kinase-related 0.104 0.4139 0.409
Echinococcus granulosus tyrosine protein kinase Srms 0.1807 1 1
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Toxoplasma gondii protein kinase domain-containing protein 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0767 0.2051 0.2051
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1807 1 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.104 0.4139 0.4139
Brugia malayi hypothetical protein 0.104 0.4139 0.2627
Plasmodium falciparum protein kinase, putative 0.104 0.4139 0.5
Loa Loa (eye worm) TK protein kinase 0.1807 1 1
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.104 0.4139 0.409
Echinococcus granulosus receptor type guanylyl cyclase 0.104 0.4139 0.4139
Echinococcus granulosus tyrosine protein kinase Fyn 0.1807 1 1
Schistosoma mansoni tensin-related 0.0767 0.2051 0.1985
Echinococcus granulosus natriuretic peptide receptor 1 0.104 0.4139 0.4139
Echinococcus granulosus tyrosine protein kinase Src64B 0.1807 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.1807 1 1
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis fibroblast growth factor receptor 4 0.104 0.4139 0.4139
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Schistosoma mansoni tyrosine-protein kinase fps85d 0.104 0.4139 0.409
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Trichomonas vaginalis conserved hypothetical protein 0.104 0.4139 0.5
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1807 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.104 0.4139 0.409
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Echinococcus granulosus expressed conserved protein 0.0767 0.2051 0.2051
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis heat shock protein 70 0.104 0.4139 0.4139
Trichomonas vaginalis conserved hypothetical protein 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Echinococcus multilocularis tyrosine protein kinase Blk 0.1807 1 1
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.104 0.4139 0.347
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.104 0.4139 0.2627
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.104 0.4139 0.5
Echinococcus multilocularis dual specificity testis specific protein kinase 0.104 0.4139 0.4139
Schistosoma mansoni tyrosine kinase 0.1807 1 1
Echinococcus multilocularis SH2 motif 0.0767 0.2051 0.2051
Schistosoma mansoni SH2A 0.0767 0.2051 0.1985
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Echinococcus multilocularis N chimaerin 0.0767 0.2051 0.2051
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Trypanosoma brucei Flagellum attachment zone protein 20 0.104 0.4139 0.5
Onchocerca volvulus 0.104 0.4139 0.347
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) TK protein kinase 0.104 0.4139 0.409
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Echinococcus granulosus adam 17 protease 0.0874 0.2868 0.2868
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Schistosoma mansoni growth factor receptor-bound protein 0.0767 0.2051 0.1985
Trichomonas vaginalis conserved hypothetical protein 0.104 0.4139 0.5
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.104 0.4139 0.4139
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0767 0.2051 0.2051
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.104 0.4139 0.2627
Plasmodium falciparum protein kinase, putative 0.104 0.4139 0.5
Schistosoma mansoni nck2/grb4 0.0767 0.2051 0.1985
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.104 0.4139 0.4139
Brugia malayi Protein kinase domain containing protein 0.1807 1 1
Echinococcus multilocularis protein kinase 0.104 0.4139 0.4139
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.104 0.4139 0.409
Entamoeba histolytica receptor protein kinase, putative 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0767 0.2051 0.1985
Loa Loa (eye worm) RGC/RGC protein kinase 0.104 0.4139 0.409
Brugia malayi Raf kinase 0.104 0.4139 0.2627
Brugia malayi Protein kinase domain containing protein 0.1807 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0767 0.2051 0.2051
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Loa Loa (eye worm) TK/DDR protein kinase 0.104 0.4139 0.409
Entamoeba histolytica hypothetical protein 0.104 0.4139 0.2627
Echinococcus granulosus retinal guanylyl cyclase 2 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Loa Loa (eye worm) TK/Met protein kinase 0.104 0.4139 0.409
Entamoeba histolytica tyrosin kinase, putative 0.104 0.4139 0.2627
Echinococcus granulosus tyrosine protein kinase csk 0.104 0.4139 0.4139
Loa Loa (eye worm) RGC/RGC protein kinase 0.104 0.4139 0.409
Echinococcus multilocularis tyrosine protein kinase shark 0.1807 1 1
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus multilocularis activin receptor type 0.104 0.4139 0.4139
Schistosoma mansoni tyrosine kinase 0.1807 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Giardia lamblia Protein 21.1 0.104 0.4139 0.5
Loa Loa (eye worm) TK protein kinase 0.104 0.4139 0.409
Plasmodium vivax tyrosine kinase-like protein, putative 0.104 0.4139 0.5
Echinococcus multilocularis protein tyrosine kinase 0.104 0.4139 0.4139
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Echinococcus granulosus NCK adaptor protein 0.0767 0.2051 0.2051
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0767 0.2051 0.1985
Loa Loa (eye worm) RGC/RGC protein kinase 0.104 0.4139 0.409
Trichomonas vaginalis conserved hypothetical protein 0.104 0.4139 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1807 1 1
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Echinococcus granulosus tyrosine protein kinase Src42A 0.1807 1 1
Echinococcus granulosus activated cdc42 kinase 1 0.104 0.4139 0.4139
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Echinococcus granulosus suppressor of cytokine signaling 7 0.0767 0.2051 0.2051
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.104 0.4139 0.4139
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Onchocerca volvulus 0.1807 1 1
Echinococcus multilocularis tyrosine protein kinase 0.104 0.4139 0.4139
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0767 0.2051 0.2051
Loa Loa (eye worm) TK/FER protein kinase 0.104 0.4139 0.409
Entamoeba histolytica tyrosin kinase, putative 0.104 0.4139 0.2627
Loa Loa (eye worm) serine/threonine protein kinase 0.104 0.4139 0.409
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Echinococcus multilocularis retinal guanylyl cyclase 2 0.104 0.4139 0.4139
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Schistosoma mansoni tensin-related 0.0767 0.2051 0.1985
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0767 0.2051 0.1985
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.104 0.4139 0.409
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.104 0.4139 0.409
Brugia malayi Tyrosine-protein kinase PR2 0.104 0.4139 0.2627
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0767 0.2051 0.1985
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus granulosus protein kinase 0.104 0.4139 0.4139
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Entamoeba histolytica cysteine surface protein, putative 0.104 0.4139 0.2627
Onchocerca volvulus 0.1807 1 1
Brugia malayi Receptor family ligand binding region containing protein 0.104 0.4139 0.2627
Entamoeba histolytica tyrosine kinase, putative 0.104 0.4139 0.2627
Loa Loa (eye worm) hypothetical protein 0.167 0.8951 0.8942
Echinococcus granulosus tyrosine kinase 0.1807 1 1
Onchocerca volvulus 0.104 0.4139 0.347
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Echinococcus multilocularis FL cytokine receptor 0.104 0.4139 0.4139
Onchocerca volvulus 0.104 0.4139 0.347
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.1807 1 1
Loa Loa (eye worm) matrixin family protein 0.0633 0.1024 0.095
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Echinococcus granulosus tyrosine protein kinase HCK 0.104 0.4139 0.4139
Schistosoma mansoni tyrosine kinase 0.1807 1 1
Giardia lamblia Kinase, NEK 0.104 0.4139 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.104 0.4139 0.2627
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.104 0.4139 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.104 0.4139 0.2627
Schistosoma mansoni serine/threonine protein kinase 0.104 0.4139 0.409
Echinococcus granulosus tyrosine kinase 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.104 0.4139 0.409
Brugia malayi hypothetical protein 0.104 0.4139 0.2627
Entamoeba histolytica serine/threonine kinase, putative 0.104 0.4139 0.2627
Loa Loa (eye worm) TK/ABL protein kinase 0.1807 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.1807 1 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0767 0.2051 0.2051
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus multilocularis receptor type guanylyl cyclase 0.104 0.4139 0.4139
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Loa Loa (eye worm) TK/FER protein kinase 0.104 0.4139 0.409
Schistosoma mansoni hypothetical protein 0.0767 0.2051 0.1985
Brugia malayi Immunoglobulin I-set domain containing protein 0.104 0.4139 0.2627
Echinococcus multilocularis tyrosine protein kinase pr2 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1807 1 1
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Entamoeba histolytica protein kinase, putative 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Onchocerca volvulus 0.0767 0.2051 0.1144
Schistosoma mansoni adapter molecule crk 0.0767 0.2051 0.1985
Loa Loa (eye worm) hypothetical protein 0.104 0.4139 0.409
Echinococcus granulosus kinase suppressor of Ras 1 0.104 0.4139 0.4139
Onchocerca volvulus 0.0767 0.2051 0.1144
Loa Loa (eye worm) TK/CSK protein kinase 0.104 0.4139 0.409
Schistosoma mansoni shc transforming protein 0.0767 0.2051 0.1985
Brugia malayi Protein kinase domain containing protein 0.1807 1 1
Schistosoma mansoni ephrin receptor 0.104 0.4139 0.409
Loa Loa (eye worm) TK/INSR protein kinase 0.104 0.4139 0.409
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0767 0.2051 0.1985
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.104 0.4139 0.4139
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1807 1 1
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Schistosoma mansoni protein kinase 0.104 0.4139 0.409
Schistosoma mansoni vav2 0.0767 0.2051 0.1985
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Echinococcus granulosus tyrosine protein kinase pr2 0.104 0.4139 0.4139
Echinococcus multilocularis ephrin type A receptor 4 A 0.104 0.4139 0.4139
Loa Loa (eye worm) SH2 domain-containing protein 0.0767 0.2051 0.1985
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1807 1 1
Schistosoma mansoni serine/threonine protein kinase 0.104 0.4139 0.409
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis transfer RNA-Thr 0.104 0.4139 0.4139
Echinococcus granulosus N chimaerin 0.0767 0.2051 0.2051
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.104 0.4139 0.4139
Echinococcus multilocularis SH2 motif 0.0767 0.2051 0.2051
Loa Loa (eye worm) TK/FER protein kinase 0.1807 1 1
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus granulosus growth factor receptor bound protein 2 0.0767 0.2051 0.2051
Echinococcus granulosus SH2 motif 0.0767 0.2051 0.2051
Loa Loa (eye worm) hypothetical protein 0.0767 0.2051 0.1985
Trichomonas vaginalis protein kinase atn1, putative 0.104 0.4139 0.5
Brugia malayi Matrixin family protein 0.0914 0.3172 0.1411
Schistosoma mansoni tyrosine kinase 0.1807 1 1
Onchocerca volvulus 0.104 0.4139 0.347
Echinococcus granulosus hypothetical protein 0.0767 0.2051 0.2051
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Onchocerca volvulus 0.104 0.4139 0.347
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.104 0.4139 0.5
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus multilocularis protein kinase 0.104 0.4139 0.4139
Loa Loa (eye worm) TK protein kinase 0.104 0.4139 0.409
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0767 0.2051 0.2051
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0767 0.2051 0.1985
Schistosoma mansoni serine/threonine protein kinase 0.104 0.4139 0.409
Schistosoma mansoni tyrosine kinase 0.104 0.4139 0.409
Brugia malayi Protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus multilocularis insulin receptor 0.104 0.4139 0.4139
Entamoeba histolytica protein kinase domain containing protein 0.104 0.4139 0.2627
Echinococcus granulosus epidermal growth factor receptor 0.104 0.4139 0.4139
Trichomonas vaginalis TKL family protein kinase 0.104 0.4139 0.5
Echinococcus granulosus tensin 0.0767 0.2051 0.2051

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.072 uM Inhibition of human GAL4-DBD-fused ERRalpha-LBD transcriptional activity transfected in human 293FT cells assessed as disruption of interaction with PGC-1alpha after 24 hrs by dual luciferase reporter gene assay ChEMBL. 23656512

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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