Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0293 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0293 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0293 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0293 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0293 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0293 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0293 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0293 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0293 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0293 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0293 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0293 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0293 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0293 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0293 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0293 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0293 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0293 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0293 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0293 | 0.5 | 0.5 | |
Brugia malayi | SH2 domain containing protein | 0.0293 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0293 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0293 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0293 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0293 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0293 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0293 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0293 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 26.5 uM | Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate after 10 mins by UV endpoint analysis | ChEMBL. | 23628333 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in insect cells using pyruvate as substrate after 10 mins by UV endpoint analysis | ChEMBL. | 23628333 |
Kd (binding) | = 640 uM | Binding affinity to human recombinant carboxy-terminal avi-tagged LDHA (1 to 331) expressed in Escherichia coli by surface plasmon resonance analysis presence of NADH | ChEMBL. | 23628333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.