Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.0089 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Onchocerca volvulus | 0.0065 | 0.0508 | 0.1237 | |
Plasmodium falciparum | plasmepsin X | 0.0046 | 0.019 | 0.0432 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.4394 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0065 | 0.0508 | 0.1157 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Brugia malayi | dihydrofolate reductase family protein | 0.0089 | 0.0889 | 0.0889 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0287 | 0.405 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0046 | 0.019 | 0.0468 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.4394 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0193 | 0.2547 | 0.5796 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0065 | 0.0508 | 0.1715 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0193 | 0.2547 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0065 | 0.0508 | 0.1237 |
Onchocerca volvulus | 0.0065 | 0.0508 | 0.1237 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0046 | 0.019 | 0.0468 |
Brugia malayi | thymidylate synthase | 0.0219 | 0.2965 | 0.2965 |
Loa Loa (eye worm) | thymidylate synthase | 0.0219 | 0.2965 | 0.2849 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0219 | 0.2965 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0065 | 0.0508 | 0.1715 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0065 | 0.0508 | 0.1157 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.0508 | 1 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0046 | 0.019 | 0.019 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0089 | 0.0889 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0193 | 0.2547 | 0.5796 |
Plasmodium falciparum | plasmepsin II | 0.0193 | 0.2547 | 0.5796 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0508 | 0.0352 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Plasmodium vivax | vivapain-2 | 0.0065 | 0.0508 | 0.1157 |
Onchocerca volvulus | 0.0219 | 0.2965 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Onchocerca volvulus | 0.0065 | 0.0508 | 0.1237 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0044 | 0.0162 | 0.0368 |
Onchocerca volvulus | 0.0065 | 0.0508 | 0.1237 | |
Loa Loa (eye worm) | fibroinase | 0.0065 | 0.0508 | 0.0352 |
Brugia malayi | Pepsin A precursor | 0.0046 | 0.019 | 0.019 |
Schistosoma mansoni | dihydrofolate reductase | 0.0089 | 0.0889 | 0.2195 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0046 | 0.019 | 0.0468 |
Brugia malayi | hypothetical protein | 0.0046 | 0.019 | 0.019 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0162 | 0.0635 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0046 | 0.019 | 0.0028 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0219 | 0.2965 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.4394 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.4394 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0308 | 0.4394 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0287 | 0.405 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0065 | 0.0508 | 0.0352 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0065 | 0.0508 | 0.1157 |
Loa Loa (eye worm) | ctsf protein | 0.0065 | 0.0508 | 0.0352 |
Plasmodium falciparum | plasmepsin VII | 0.0046 | 0.019 | 0.0432 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Brugia malayi | Cathepsin L-like precursor | 0.0065 | 0.0508 | 0.0508 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0193 | 0.2547 | 0.859 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Echinococcus multilocularis | thymidylate synthase | 0.0219 | 0.2965 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0065 | 0.0508 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0046 | 0.019 | 0.0468 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0065 | 0.0508 | 0.1715 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0046 | 0.019 | 0.019 |
Loa Loa (eye worm) | cysteine protease | 0.0065 | 0.0508 | 0.0352 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0065 | 0.0508 | 0.1157 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0065 | 0.0508 | 0.1255 |
Echinococcus granulosus | dihydrofolate reductase | 0.0089 | 0.0889 | 0.2999 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0193 | 0.2547 | 0.5607 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.2547 | 0.2424 |
Plasmodium vivax | plasmepsin V, putative | 0.0046 | 0.019 | 0.0432 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0046 | 0.019 | 0.0468 |
Onchocerca volvulus | Cathepsin L homolog | 0.0065 | 0.0508 | 0.1237 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.0508 | 0.1157 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.0508 | 0.1157 |
Plasmodium vivax | aspartyl protease, putative | 0.0046 | 0.019 | 0.0432 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0044 | 0.0162 | 0.0162 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Plasmodium vivax | plasmepsin IV, putative | 0.0193 | 0.2547 | 0.5796 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0046 | 0.019 | 0.0099 | |
Plasmodium falciparum | plasmepsin IV | 0.0193 | 0.2547 | 0.5796 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0658 | 1 | 1 |
Onchocerca volvulus | 0.0065 | 0.0508 | 0.1237 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Brugia malayi | Cathepsin L-like precursor | 0.0065 | 0.0508 | 0.0508 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0065 | 0.0508 | 0.1715 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.0508 | 0.1157 |
Toxoplasma gondii | cathepsin CPL | 0.0065 | 0.0508 | 0.0758 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0089 | 0.0889 | 0.2999 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0089 | 0.0889 | 0.0739 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0065 | 0.0508 | 0.0352 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0193 | 0.2547 | 0.859 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0046 | 0.019 | 0.0432 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Mycobacterium ulcerans | thymidylate synthase | 0.0219 | 0.2965 | 1 |
Plasmodium falciparum | plasmepsin IX | 0.0046 | 0.019 | 0.0432 |
Brugia malayi | hypothetical protein | 0.0046 | 0.019 | 0.019 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0065 | 0.0508 | 0.1255 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.019 | 0.0028 |
Echinococcus multilocularis | cysteine protease | 0.0065 | 0.0508 | 0.1715 |
Plasmodium falciparum | plasmepsin V | 0.0046 | 0.019 | 0.0432 |
Onchocerca volvulus | 0.0065 | 0.0508 | 0.1237 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0065 | 0.0508 | 0.1715 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0104 | 0.1127 | 0.2565 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.0508 | 0.1157 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0193 | 0.2547 | 0.6288 |
Brugia malayi | Cathepsin L-like precursor | 0.0065 | 0.0508 | 0.0508 |
Brugia malayi | cathepsin L-like precursor | 0.0044 | 0.0162 | 0.0162 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0046 | 0.019 | 0.0468 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0193 | 0.2547 | 0.5607 |
Echinococcus granulosus | cathepsin l1 | 0.0044 | 0.0162 | 0.0546 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0193 | 0.2547 | 0.2424 |
Plasmodium vivax | aspartyl protease, putative | 0.0046 | 0.019 | 0.0432 |
Brugia malayi | hypothetical protein | 0.0104 | 0.1127 | 0.1127 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0046 | 0.019 | 0.0468 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.4394 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0044 | 0.0162 | 0.0399 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0162 | 0.0635 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0104 | 0.1127 | 0.1148 |
Plasmodium vivax | aspartyl protease, putative | 0.0046 | 0.019 | 0.0432 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0065 | 0.0508 | 0.1715 |
Onchocerca volvulus | Cathepsin L homolog | 0.0065 | 0.0508 | 0.1237 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0046 | 0.019 | 0.0468 |
Plasmodium falciparum | plasmepsin III | 0.0046 | 0.019 | 0.0432 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0162 | 0.0162 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0065 | 0.0508 | 0.0508 |
Plasmodium falciparum | plasmepsin VI | 0.0193 | 0.2547 | 0.5796 |
Brugia malayi | Cathepsin L-like precursor | 0.0065 | 0.0508 | 0.0508 |
Echinococcus multilocularis | cysteine protease | 0.0065 | 0.0508 | 0.1715 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0046 | 0.019 | 0.019 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0046 | 0.019 | 0.0028 |
Brugia malayi | sulfakinin receptor protein | 0.0658 | 1 | 1 |
Onchocerca volvulus | 0.0046 | 0.019 | 0.0099 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 0.1127 | 0.4426 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0046 | 0.019 | 0.0432 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0065 | 0.0508 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0219 | 0.2965 | 0.7319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0044 | 0.0162 | 0.3182 |
Echinococcus granulosus | thymidylate synthase | 0.0219 | 0.2965 | 1 |
Plasmodium vivax | vivapain-2 | 0.0065 | 0.0508 | 0.1157 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0508 | 0.1157 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0065 | 0.0508 | 0.1715 |
Brugia malayi | Cathepsin L-like precursor | 0.0065 | 0.0508 | 0.0508 |
Onchocerca volvulus | 0.0065 | 0.0508 | 0.1237 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.0508 | 0.1997 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.019 | 0.0028 |
Brugia malayi | Cathepsin L-like precursor | 0.0065 | 0.0508 | 0.0508 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0046 | 0.019 | 0.0468 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.663 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.061 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.915 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.885 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.871 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.825 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.821 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.723 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.