Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0072 | 0.1447 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0072 | 0.1447 | 0.1447 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0072 | 0.1447 | 0.5 |
Onchocerca volvulus | 0.0072 | 0.1447 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0072 | 0.1447 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0072 | 0.1447 | 0.1181 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0072 | 0.1447 | 0.1447 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1447 | 0.1447 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0072 | 0.1447 | 0.1181 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.1447 | 0.1447 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0072 | 0.1447 | 0.1181 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.1447 | 0.1264 |
Onchocerca volvulus | 0.0072 | 0.1447 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0072 | 0.1447 | 0.1447 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.1447 | 0.1264 |
Brugia malayi | Carboxylesterase family protein | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1447 | 0.1447 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1447 | 0.1447 |
Schistosoma mansoni | gliotactin | 0.0072 | 0.1447 | 0.1447 |
Onchocerca volvulus | 0.0072 | 0.1447 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1447 | 0.1447 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1447 | 0.1447 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0072 | 0.1447 | 0.1181 |
Schistosoma mansoni | acetylcholinesterase | 0.0072 | 0.1447 | 0.1447 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0072 | 0.1447 | 0.1181 |
Onchocerca volvulus | 0.0072 | 0.1447 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.1447 | 0.1264 |
Onchocerca volvulus | 0.0072 | 0.1447 | 1 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0072 | 0.1447 | 0.1181 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.1447 | 0.1264 |
Echinococcus multilocularis | acetylcholinesterase | 0.0428 | 1 | 1 |
Brugia malayi | plexin A | 0.0025 | 0.0301 | 0.0094 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0.1447 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.021 | 0.021 |
Echinococcus granulosus | acetylcholinesterase | 0.0428 | 1 | 1 |
Schistosoma mansoni | plexin | 0.0021 | 0.021 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0428 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0428 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0428 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0072 | 0.1447 | 0.1264 |
Echinococcus multilocularis | neuroligin | 0.0072 | 0.1447 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1447 | 0.1447 |
Loa Loa (eye worm) | carboxylesterase | 0.0428 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0.1447 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1447 | 0.1447 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.1447 | 0.1447 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0072 | 0.1447 | 0.1447 |
Loa Loa (eye worm) | plexin A | 0.0025 | 0.0301 | 0.0301 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.1447 | 0.1447 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0072 | 0.1447 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0072 | 0.1447 | 0.1181 |
Echinococcus multilocularis | acetylcholinesterase | 0.0428 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0428 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.36 uM | Inhibition of c-MET (unknown origin) after 60 mins by ELISA | ChEMBL. | 23474386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.