Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.3044 | 0.3044 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | carboxylesterase | 0.0014 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0016 | 0.0016 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0692 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0692 | 0.0692 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0092 | 0.0076 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.1767 | 0.5785 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3044 | 0.3044 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0014 | 0.0016 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0014 | 0.0016 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0016 | 0.0016 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.3044 | 0.3032 |
Loa Loa (eye worm) | carboxylesterase | 0.0014 | 0.0016 | 0.0016 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0014 | 0.0016 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0668 | 0.0668 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3044 | 1 |
Onchocerca volvulus | 0.0029 | 0.0692 | 1 | |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0692 | 0.2231 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.3044 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.3044 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.3044 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0238 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0692 | 0.0677 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0692 | 0.2231 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3044 | 1 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0692 | 0.2231 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0692 | 0.2231 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0014 | 0.0016 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3044 | 1 |
Echinococcus granulosus | lamin | 0.0029 | 0.0692 | 0.2231 |
Onchocerca volvulus | 0.0029 | 0.0692 | 1 | |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.0024 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0016 | 0.0016 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0024 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3044 | 0.3044 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.3044 | 0.3032 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.3044 | 0.3044 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0016 | 0.0016 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0692 | 0.0677 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0014 | 0.0016 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0692 | 0.0692 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0014 | 0.0016 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0092 | 0.0092 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0692 | 0.2231 |
Schistosoma mansoni | lamin | 0.0029 | 0.0692 | 0.2231 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0016 | 0.0016 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3044 | 1 |
Schistosoma mansoni | lamin | 0.0029 | 0.0692 | 0.2231 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.78 uM | Inhibition of acetylcholine esterase (unknown origin) using acetylthiocholine as substrate incubated for 15 mins prior to substrate addition measured after 5 mins by spectrophotometry | ChEMBL. | 23603045 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.