Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.6941 | 0.6941 |
Plasmodium falciparum | ras-related protein Rab-5A | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0014 | 0.0805 | 0.116 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0014 | 0.0805 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0805 | 0.0811 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.6941 | 0.699 |
Onchocerca volvulus | 0.0014 | 0.0805 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.6941 | 0.699 |
Loa Loa (eye worm) | carboxylesterase | 0.0014 | 0.0805 | 0.0811 |
Onchocerca volvulus | 0.0014 | 0.0805 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0805 | 0.116 |
Onchocerca volvulus | 0.0014 | 0.0805 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0805 | 0.116 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0014 | 0.0805 | 0.0805 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.6941 | 0.699 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0014 | 0.0805 | 0.116 |
Brugia malayi | Protein kinase domain containing protein | 0.0115 | 0.993 | 1 |
Trypanosoma brucei | Rab-like 5, small G protein | 0.0005 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.6941 | 0.6941 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.6941 | 0.699 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.6941 | 0.6941 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0805 | 0.0811 |
Loa Loa (eye worm) | carboxylesterase | 0.0014 | 0.0805 | 0.0811 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0115 | 0.993 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.6941 | 0.699 |
Schistosoma mansoni | acetylcholinesterase | 0.0014 | 0.0805 | 0.116 |
Leishmania major | hypothetical protein, conserved | 0.0005 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0805 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0805 | 0.0811 |
Onchocerca volvulus | 0.0014 | 0.0805 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0014 | 0.0805 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.6941 | 0.699 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0805 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0805 | 0.0811 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0014 | 0.0805 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.6941 | 0.699 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0014 | 0.0805 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0014 | 0.0805 | 0.5 |
Trypanosoma cruzi | Rab-like 5, small G protein | 0.0005 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0005 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0014 | 0.0805 | 0.0805 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0014 | 0.0805 | 0.0805 |
Echinococcus multilocularis | neuroligin | 0.0014 | 0.0805 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.6941 | 0.699 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0005 | 0 | 0.5 |
Plasmodium vivax | ras-related protein Rab-5A, putative | 0.0005 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0005 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0805 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0805 | 0.0811 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0014 | 0.0805 | 0.0811 |
Entamoeba histolytica | hypothetical protein | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0805 | 0.0811 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0014 | 0.0805 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.6941 | 0.699 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.6941 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0805 | 0.0811 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0805 | 0.0811 |
Schistosoma mansoni | gliotactin | 0.0014 | 0.0805 | 0.116 |
Entamoeba histolytica | hypothetical protein | 0.0005 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0014 | 0.0805 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0014 | 0.0805 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0805 | 0.0811 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0115 | 0.993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0805 | 0.0811 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0805 | 0.116 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0014 | 0.0805 | 0.0811 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0005 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.27 uM | Inhibition of BuChE (unknown origin) by Ellman method | ChEMBL. | 23540646 |
Inhibition (binding) | Inhibition of AChE (unknown origin) at 2 uM by Ellman method | ChEMBL. | 23540646 | |
Inhibition (binding) | Inhibition of BuChE (unknown origin) at 10 uM by Ellman method | ChEMBL. | 23540646 | |
Inhibition (binding) | = 30 % | Inhibition of amyloid beta (1 to 40) (unknown origin) fibril formation at 100 uM after 4 to 6 days by Thioflavin-T fluorescence microscopy | ChEMBL. | 23540646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.