Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.2233 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0065 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.2233 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2233 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.2233 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2233 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2233 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0065 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.2233 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.2233 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.2233 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.0077 | 0.0077 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2233 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2233 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.0077 | 0.0077 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2233 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.0077 | 0.0077 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.2233 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.0077 | 0.0077 |
Trypanosoma brucei | protein kinase, putative | 0.2233 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0864 | 0.3686 | 0.3686 |
Plasmodium falciparum | protein kinase 5 | 0.0065 | 0 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0077 | 0.0077 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.2233 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.2233 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2233 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.0077 | 0.0077 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | camk/mapkapk/mnk protein kinase | 0.0864 | 0.3686 | 0.3686 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.0077 | 0.0077 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.2233 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.2233 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.0077 | 0.0077 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.0077 | 0.0077 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.0077 | 0.0077 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0077 | 0.0077 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.2233 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10.65 uM | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | ChEMBL. | 23583510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.