Detailed information for compound 176102

Basic information

Technical information
  • TDR Targets ID: 176102
  • Name: 3-(2-chlorophenothiazin-10-yl)propyl-[(3,4-di methylphenyl)methyl]-dimethylazanium
  • MW: 438.048 | Formula: C26H30ClN2S+
  • H donors: 0 H acceptors: 0 LogP: 7.01 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)N(CCC[N+](Cc1ccc(c(c1)C)C)(C)C)c1c(S2)cccc1
  • InChi: 1S/C26H30ClN2S/c1-19-10-11-21(16-20(19)2)18-29(3,4)15-7-14-28-23-8-5-6-9-25(23)30-26-13-12-22(27)17-24(26)28/h5-6,8-13,16-17H,7,14-15,18H2,1-4H3/q+1
  • InChiKey: NAYIMUYVNCFQLF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2-chlorophenothiazin-10-yl)propyl-[(3,4-dimethylphenyl)methyl]-dimethyl-ammonium
  • 3-(2-chloro-10-phenothiazinyl)propyl-[(3,4-dimethylphenyl)methyl]-dimethylammonium
  • 3-(2-chlorophenothiazin-10-yl)propyl-[(3,4-dimethylphenyl)methyl]-dimethyl-azanium
  • 3-(2-chlorophenothiazin-10-yl)propyl-(3,4-dimethylbenzyl)-dimethyl-ammonium

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi trypanothione reductase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 492 aa 548 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi putative neuropeptide receptor NPR1 0.0045 0.3651 0.3651
Echinococcus multilocularis g protein coupled receptor 0.0045 0.3651 0.3651
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.3651 0.3651
Plasmodium falciparum glutathione reductase 0.0076 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0045 0.3651 0.3651
Schistosoma mansoni alpha-1 adrenergic receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0045 0.3651 0.3651
Loa Loa (eye worm) glutathione reductase 0.0076 1 1
Brugia malayi hypothetical protein 0.0045 0.3651 0.3651
Echinococcus granulosus neuropeptide receptor 0.0045 0.3651 0.3651
Leishmania major trypanothione reductase 0.0076 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.3651 0.3651
Echinococcus granulosus orexin receptor type 2 0.0045 0.3651 0.3651
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0045 0.3651 0.3651
Brugia malayi sulfakinin receptor protein 0.0045 0.3651 0.3651
Onchocerca volvulus Neuropeptide F receptor homolog 0.0045 0.3651 0.5
Echinococcus multilocularis orexin receptor type 2 0.0045 0.3651 0.3651
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.3651 0.3651
Schistosoma mansoni amine GPCR 0.0045 0.3651 0.3651
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Brugia malayi hypothetical protein 0.0045 0.3651 0.3651
Schistosoma mansoni hypothetical protein 0.0045 0.3651 0.3651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.3651 0.3651
Schistosoma mansoni biogenic amine receptor 0.0045 0.3651 0.3651
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Echinococcus granulosus neuropeptide FF receptor 2 0.0045 0.3651 0.3651
Schistosoma mansoni opsin-like receptor 0.0045 0.3651 0.3651
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0 0.5
Brugia malayi G-protein coupled receptor 0.0045 0.3651 0.3651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.3651 0.3651
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.3651 0.3651
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.3651 0.3651
Schistosoma mansoni biogenic amine receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.3651 0.3651
Plasmodium falciparum thioredoxin reductase 0.0076 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0045 0.3651 0.3651
Echinococcus granulosus neuropeptide s receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis somatostatin receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis fmrfamide receptor 0.0045 0.3651 0.3651
Echinococcus granulosus g protein coupled receptor 0.0045 0.3651 0.3651
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0045 0.3651 0.3651
Echinococcus multilocularis G protein coupled receptor 139 0.0045 0.3651 0.3651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.3651 0.3651
Echinococcus multilocularis fmrfamide receptor 0.0045 0.3651 0.3651
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.3651 0.3651
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0045 0.3651 0.5
Brugia malayi hypothetical protein 0.0045 0.3651 0.3651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Brugia malayi neuropeptide F receptor 0.0045 0.3651 0.3651
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.3651 0.3651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.3651 0.3651
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.3651 0.3651
Echinococcus granulosus neuropeptide receptor A26 0.0045 0.3651 0.3651
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0045 0.3651 0.3651
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.3651 0.3651
Schistosoma mansoni neuropeptide receptor 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus granulosus allatostatin A receptor 0.0045 0.3651 0.3651
Schistosoma mansoni hypothetical protein 0.0045 0.3651 0.3651
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0045 0.3651 0.3651
Echinococcus granulosus alpha 1A adrenergic receptor 0.0045 0.3651 0.3651
Brugia malayi G-protein coupled receptor 0.0045 0.3651 0.3651
Schistosoma mansoni neuropeptide receptor 0.0045 0.3651 0.3651
Schistosoma mansoni neuropeptide receptor 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus multilocularis serotonin receptor 0.0045 0.3651 0.3651
Schistosoma mansoni amine GPCR 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0045 0.3651 0.3651
Echinococcus multilocularis neuropeptide receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis neuropeptide receptor A26 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus granulosus fmrfamide receptor 0.0045 0.3651 0.3651
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.3651 0.3651
Echinococcus granulosus sex peptide receptor 0.0045 0.3651 0.3651
Brugia malayi hypothetical protein 0.0045 0.3651 0.3651
Trypanosoma cruzi trypanothione reductase, putative 0.0076 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0 0.5
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0045 0.3651 0.3651
Schistosoma mansoni amine GPCR 0.0045 0.3651 0.3651
Echinococcus multilocularis neuropeptide FF receptor 2 0.0045 0.3651 0.3651
Echinococcus granulosus G protein coupled receptor 139 0.0045 0.3651 0.3651
Toxoplasma gondii thioredoxin reductase 0.0076 1 1
Schistosoma mansoni amine GPCR 0.0045 0.3651 0.3651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.3651 0.3651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.3651 0.3651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.3651 0.3651
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 1 1
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0045 0.3651 0.3651
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0045 0.3651 0.3651
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0 0.5
Brugia malayi Melatonin receptor type 1A 0.0045 0.3651 0.3651
Brugia malayi Serotonin receptor 0.0045 0.3651 0.3651
Brugia malayi hypothetical protein 0.0045 0.3651 0.3651
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.3651 0.3651
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0045 0.3651 0.3651
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.3651 0.3651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.3651 0.3651
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0045 0.3651 0.3651
Brugia malayi neuropeptide F receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis serotonin receptor 0.0045 0.3651 0.3651
Schistosoma mansoni histamine h1 receptor 0.0045 0.3651 0.3651
Schistosoma mansoni hypothetical protein 0.0045 0.3651 0.3651
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0026 0 0.5
Plasmodium vivax glutathione reductase, putative 0.0076 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0045 0.3651 0.3651
Brugia malayi putative neuropeptide receptor 0.0045 0.3651 0.3651
Trichomonas vaginalis mercuric reductase, putative 0.0026 0 0.5
Brugia malayi larval opioid receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0045 0.3651 0.3651
Brugia malayi Dopamine receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Echinococcus multilocularis g protein coupled receptor 0.0045 0.3651 0.3651
Echinococcus granulosus serotonin receptor 0.0045 0.3651 0.3651
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0045 0.3651 0.3651
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.3651 0.3651
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Brugia malayi AKH receptor 0.0045 0.3651 0.3651
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.3651 0.3651
Schistosoma mansoni myosin xvIII 0.0045 0.3651 0.3651
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.3651 0.3651
Schistosoma mansoni biogenic amine receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis g protein coupled receptor 0.0045 0.3651 0.3651
Treponema pallidum NADH oxidase 0.0026 0 0.5
Trichomonas vaginalis glutathione reductase, putative 0.0026 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Echinococcus multilocularis sex peptide receptor 0.0045 0.3651 0.3651
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0045 0.3651 0.3651
Brugia malayi GnHR receptor homolog 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.3651 0.3651
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus granulosus g-protein coupled receptor 0.0045 0.3651 0.3651
Brugia malayi Serotonin receptor 0.0045 0.3651 0.3651
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Echinococcus multilocularis allatostatin A receptor 0.0045 0.3651 0.3651
Brugia malayi follicle stimulating hormone receptor 0.0045 0.3651 0.3651
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0045 0.3651 0.3651
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.3651 0.3651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Brugia malayi hypothetical protein 0.0045 0.3651 0.3651
Schistosoma mansoni amine GPCR 0.0045 0.3651 0.3651
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.3651 0.3651
Echinococcus granulosus g protein coupled receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis neuropeptide s receptor 0.0045 0.3651 0.3651
Echinococcus granulosus peptide allatostatin:somatostatin 0.0045 0.3651 0.3651
Plasmodium vivax thioredoxin reductase, putative 0.0076 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0045 0.3651 0.3651
Loa Loa (eye worm) thioredoxin reductase 0.0076 1 1
Onchocerca volvulus 0.0045 0.3651 0.5
Onchocerca volvulus 0.0045 0.3651 0.5
Brugia malayi hypothetical protein 0.0045 0.3651 0.3651
Echinococcus granulosus 7tm_1 domain containing protein 0.0045 0.3651 0.3651
Brugia malayi Thioredoxin reductase 0.0076 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.3651 0.3651
Brugia malayi RE15519p 0.0045 0.3651 0.3651
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.3651 0.3651
Brugia malayi Dopamine receptor protein 2 0.0045 0.3651 0.3651
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.3651 0.3651
Echinococcus granulosus 7TM GPCR rhodopsin 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0045 0.3651 0.3651
Schistosoma mansoni adenoreceptor 0.0045 0.3651 0.3651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Schistosoma mansoni opsin-like receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis G-protein coupled receptor, putative 0.0045 0.3651 0.3651
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0045 0.3651 0.3651
Brugia malayi hypothetical protein 0.0045 0.3651 0.3651
Echinococcus granulosus hypothetical protein 0.0045 0.3651 0.3651
Schistosoma mansoni hypothetical protein 0.0045 0.3651 0.3651
Brugia malayi ORL1-like opioid receptor 0.0045 0.3651 0.3651
Trypanosoma brucei trypanothione reductase 0.0076 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0045 0.3651 0.3651
Echinococcus granulosus somatostatin receptor 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.3651 0.3651
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0045 0.3651 0.3651
Brugia malayi G protein-coupled receptor F59B2.13 0.0045 0.3651 0.3651
Echinococcus multilocularis neuropeptide receptor 0.0045 0.3651 0.3651
Echinococcus granulosus tachykinin peptides receptor 99D 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Brugia malayi G protein-coupled receptor 0.0045 0.3651 0.3651
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0045 0.3651 0.3651
Echinococcus granulosus dro:myosuppressin receptor 0.0045 0.3651 0.3651
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.3651 0.3651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Brugia malayi Dopamine receptor protein 1 0.0045 0.3651 0.3651
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.3651 0.3651
Brugia malayi hypothetical protein 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Onchocerca volvulus 0.0045 0.3651 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0045 0.3651 0.3651
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.3651 0.3651
Echinococcus granulosus neuropeptide receptor 0.0045 0.3651 0.3651
Schistosoma mansoni opsin-like receptor 0.0045 0.3651 0.3651
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.3651 0.3651
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0045 0.3651 0.3651
Onchocerca volvulus 0.0045 0.3651 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0045 0.3651 0.3651
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.3651 0.3651
Brugia malayi hypothetical protein 0.0045 0.3651 0.3651
Schistosoma mansoni neuropeptide receptor 0.0045 0.3651 0.3651
Brugia malayi Tachykinin-like peptides receptor 99D 0.0045 0.3651 0.3651
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0 0.5
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0076 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.9 uM Inhibitory activity against T. cruzi trypanothione reductase ChEMBL. 10956223
IC50 (binding) = 3.9 uM Inhibitory activity against T. cruzi trypanothione reductase ChEMBL. 10956223
Ki (binding) = 0.47 uM Inhibitory activity against T. cruzi trypanothione reductase ChEMBL. 10956223
Ki (binding) = 0.47 uM Inhibitory activity against T. cruzi trypanothione reductase ChEMBL. 10956223

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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