TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 298.403 | Formula: C17H18N2OS
H donors: 1 H acceptors: 0 LogP: 3.08 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)c1cccc(c1)C1(C)SCC(=N1)N
InChi: 1S/C17H18N2OS/c1-17(19-16(18)11-21-17)14-7-3-5-12(9-14)13-6-4-8-15(10-13)20-2/h3-10H,11H2,1-2H3,(H2,18,19)
InChiKey: HQOFZPLMGHLAJL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	beta-site APP-cleaving enzyme 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative	Get druggable targets OG5_135830	All targets in OG5_135830
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	memapsin-2 (A01 family)	Get druggable targets OG5_135830	All targets in OG5_135830

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	plasmepsin VII	beta-site APP-cleaving enzyme 1	401 aa	352 aa	21.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0317	0.3802	0.3802
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK protein kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	tensin-related	0.0482	0.5929	0.5929
Plasmodium falciparum	tyrosine kinase-like protein	0.0317	0.3802	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0317	0.3802	0.3802
Brugia malayi	integrin-linked kinase	0.0317	0.3802	0.3802
Leishmania major	protein kinase, putative	0.0317	0.3802	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	NCK adaptor protein	0.0482	0.5929	0.5929
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0482	0.5929	0.5929
Echinococcus multilocularis	tyrosine kinase	0.0798	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0798	1	1
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	NCK adaptor protein	0.0482	0.5929	0.5929
Schistosoma mansoni	tensin-related	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Loa Loa (eye worm)	TK/INSR protein kinase	0.0317	0.3802	0.3802
Trypanosoma brucei	protein kinase, putative	0.0317	0.3802	0.5
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine kinase	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0798	1	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0317	0.3802	0.3802
Schistosoma mansoni	hypothetical protein	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0482	0.5929	0.5929
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0317	0.3802	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0317	0.3802	1
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase shark	0.0798	1	1
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	Variant SH3 domain containing protein	0.0482	0.5929	0.5929
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0798	1	1
Echinococcus multilocularis	tyrosine protein kinase	0.0317	0.3802	0.3802
Brugia malayi	SH2 domain containing protein	0.0482	0.5929	0.5929
Onchocerca volvulus		0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0798	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0317	0.3802	0.3802
Plasmodium falciparum	tyrosine kinase-like protein	0.0317	0.3802	1
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Echinococcus granulosus	receptor type guanylyl cyclase	0.0317	0.3802	0.3802
Echinococcus granulosus	ephrin type A receptor 4 A	0.0317	0.3802	0.3802
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0798	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0482	0.5929	0.5929
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0482	0.5929	0.5929
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0304	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0798	1	1
Echinococcus granulosus	expressed conserved protein	0.0482	0.5929	0.5929
Echinococcus multilocularis	activated cdc42 kinase 1	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	serine/threonine protein kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0798	1	1
Onchocerca volvulus		0.0482	0.5929	0.5929
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0798	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0317	0.3802	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0482	0.5929	0.5929
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Giardia lamblia	Kinase, NEK	0.0317	0.3802	0.5
Entamoeba histolytica	protein kinase, putative	0.0482	0.5929	0.3431
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0482	0.5929	0.5929
Schistosoma mansoni	tyrosine kinase	0.0798	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	SH2 motif	0.0482	0.5929	0.5929
Schistosoma mansoni	tyrosine kinase	0.0798	1	1
Plasmodium falciparum	protein kinase, putative	0.0317	0.3802	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	TK family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0482	0.5929	0.5929
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0798	1	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0317	0.3802	0.3802
Plasmodium falciparum	protein kinase, putative	0.0317	0.3802	1
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0.3802	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0317	0.3802	0.3802
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0482	0.5929	0.5929
Echinococcus multilocularis	protein tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	transfer RNA-Thr	0.0317	0.3802	0.3802
Brugia malayi	SH2 domain containing protein	0.0482	0.5929	0.5929
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0.3802	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Entamoeba histolytica	SH2 domain containing protein	0.0482	0.5929	0.3431
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	C-terminal src kinase protein 1	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine kinase	0.0798	1	1
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus multilocularis	SH2 motif	0.0482	0.5929	0.5929
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0798	1	1
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Echinococcus multilocularis	signal transduction protein lnk realted	0.0482	0.5929	0.5929
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0798	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0798	1	1
Brugia malayi	Protein kinase domain containing protein	0.0798	1	1
Brugia malayi	Protein kinase domain containing protein	0.0798	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0317	0.3802	1
Onchocerca volvulus		0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	Protein kinase domain containing protein	0.0798	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0482	0.5929	0.5929
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0.3802	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0798	1	1
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Schistosoma mansoni	suppressor of cytokine signaling	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0482	0.5929	0.5929
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0317	0.3802	1
Loa Loa (eye worm)	hypothetical protein	0.0798	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase csk	0.0317	0.3802	0.3802
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0482	0.5929	0.5929
Onchocerca volvulus		0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0482	0.5929	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Onchocerca volvulus		0.0798	1	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0317	0.3802	0.3802
Schistosoma mansoni	growth factor receptor-bound protein	0.0482	0.5929	0.5929
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0317	0.3802	0.3802
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0317	0.3802	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0317	0.3802	1
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK protein kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	insulin receptor	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trypanosoma brucei	Pseudokinase, putative	0.0317	0.3802	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/FER protein kinase	0.0798	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0228	0.0228
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0798	1	1
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/FER protein kinase	0.0798	1	1
Schistosoma mansoni	SH2A	0.0482	0.5929	0.5929
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0482	0.5929	0.5929
Brugia malayi	Receptor family ligand binding region containing protein	0.0317	0.3802	0.3802
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0317	0.3802	0.3802
Schistosoma mansoni	vav2	0.0482	0.5929	0.5929
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0317	0.3802	0.3802
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0482	0.5929	0.3431
Brugia malayi	Furin-like cysteine rich region family protein	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0317	0.3802	0.3802
Schistosoma mansoni	tensin	0.0482	0.5929	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	SH2 domain containing protein	0.0798	1	1
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	SH2 motif	0.0482	0.5929	0.5929
Toxoplasma gondii	STE kinase	0.0317	0.3802	1
Onchocerca volvulus		0.0798	1	1
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0798	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0798	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0482	0.5929	0.5929
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0317	0.3802	0.3802
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase shark	0.0798	1	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0317	0.3802	0.3802
Leishmania major	hypothetical protein, conserved	0.0317	0.3802	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0482	0.5929	0.5929
Brugia malayi	SH2 domain containing protein	0.0798	1	1
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/CSK protein kinase	0.0317	0.3802	0.3802
Plasmodium falciparum	protein kinase, putative	0.0317	0.3802	1
Trypanosoma cruzi	protein kinase, putative	0.0317	0.3802	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0317	0.3802	0.3802
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	raf serine:threonine protein kinase	0.0317	0.3802	0.3802
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0317	0.3802	1
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0266	0.07
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0798	1	1
Giardia lamblia	Kinase, NEK	0.0317	0.3802	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0482	0.5929	0.5929
Echinococcus granulosus	SH2 domain containing protein 7	0.0482	0.5929	0.5929
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0317	0.3802	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0317	0.3802	0.3802
Schistosoma mansoni	shc transforming protein	0.0482	0.5929	0.5929
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0798	1	1
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	kinase suppressor of Ras 1	0.0317	0.3802	0.3802
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	tyrosine kinase	0.0798	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0356	0.0356
Echinococcus granulosus	hypothetical protein	0.0482	0.5929	0.5929
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0317	0.3802	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	tyrosine kinase	0.0798	1	1
Echinococcus multilocularis	SHC transforming protein 3	0.0482	0.5929	0.5929
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0317	0.3802	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0266	0.07
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0317	0.3802	0.3802
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	N chimaerin	0.0482	0.5929	0.5929
Echinococcus multilocularis	protein kinase	0.0317	0.3802	0.3802
Trypanosoma cruzi	protein kinase, putative	0.0317	0.3802	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Giardia lamblia	Kinase	0.0317	0.3802	0.5
Brugia malayi	hypothetical protein	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Loa Loa (eye worm)	TK/FAK protein kinase	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0482	0.5929	0.5929
Brugia malayi	hypothetical protein	0.0798	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0317	0.3802	0.3802
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0798	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0482	0.5929	0.5929
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0798	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0317	0.3802	0.3802
Brugia malayi	Variant SH3 domain containing protein	0.0482	0.5929	0.5929
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0798	1	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0798	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0317	0.3802	0.3802
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK protein kinase	0.0798	1	1
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0798	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0798	1	1
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	insulin receptor	0.0317	0.3802	0.3802
Echinococcus granulosus	protein kinase	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0482	0.5929	0.5929
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0317	0.3802	0.3802
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	hypothetical protein	0.0482	0.5929	0.5929
Echinococcus multilocularis	epidermal growth factor receptor	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0798	1	1
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/FER protein kinase	0.0798	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0482	0.5929	0.5929
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0.3802	1
Schistosoma mansoni	serine/threonine protein kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0317	0.3802	0.3802
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0482	0.5929	0.5929
Echinococcus multilocularis	SH2 domain containing protein 7	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	tensin	0.0482	0.5929	0.5929
Brugia malayi	hypothetical protein	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase HCK	0.0317	0.3802	0.3802
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0317	0.3802	0.3802
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	tensin	0.0482	0.5929	0.5929
Schistosoma mansoni	protein tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0798	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0304	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0798	1	1
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	activated cdc42 kinase 1	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine kinase	0.0798	1	1
Brugia malayi	Raf kinase	0.0317	0.3802	0.3802
Brugia malayi	SRC-1	0.0798	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	tyrosine kinase	0.0798	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0317	0.3802	1
Schistosoma mansoni	serine/threonine protein kinase	0.0317	0.3802	0.3802
Brugia malayi	RhoGAP domain containing protein	0.0482	0.5929	0.5929
Schistosoma mansoni	ephrin receptor	0.0317	0.3802	0.3802
Schistosoma mansoni	hypothetical protein	0.0317	0.3802	0.3802
Toxoplasma gondii	protein kinase	0.0317	0.3802	1
Onchocerca volvulus		0.0317	0.3802	0.3802
Giardia lamblia	Protein 21.1	0.0317	0.3802	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0798	1	1
Echinococcus multilocularis	heat shock protein 70	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/RYK protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	activin receptor type	0.0317	0.3802	0.3802
Echinococcus multilocularis	tensin	0.0482	0.5929	0.5929
Loa Loa (eye worm)	TK protein kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0482	0.5929	0.5929
Echinococcus multilocularis	integrin linked protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0304	0.0304
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Brugia malayi	Tyrosine-protein kinase abl-1	0.0798	1	1
Schistosoma mansoni	GTPase activating protein	0.0482	0.5929	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0.3802	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	STE family protein kinase	0.0317	0.3802	1
Echinococcus multilocularis	activin receptor type	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0317	0.3802	0.3802
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0304	0.0304
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0317	0.3802	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0482	0.5929	0.5929
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0798	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0482	0.5929	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0482	0.5929	0.5929
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0317	0.3802	0.3802
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase csk	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Echinococcus multilocularis		0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0317	0.3802	0.3802
Brugia malayi	Guanylyl cyclase protein 23	0.0317	0.3802	0.3802
Trichomonas vaginalis	CAMK family protein kinase	0.0317	0.3802	1
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Echinococcus multilocularis	c src tyrosine kinase	0.0798	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/FER protein kinase	0.0798	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0482	0.5929	0.5929
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0482	0.5929	0.5929
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0482	0.5929	0.5929
Brugia malayi	Tensin	0.0482	0.5929	0.5929
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0482	0.5929	0.5929
Onchocerca volvulus		0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0798	1	1
Schistosoma mansoni	serine/threonine RGC	0.0317	0.3802	0.3802
Schistosoma mansoni	signal transduction protein lnk-related	0.0482	0.5929	0.5929
Loa Loa (eye worm)	SH2 domain-containing protein	0.0482	0.5929	0.5929
Schistosoma mansoni	adapter molecule crk	0.0482	0.5929	0.5929
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0798	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0798	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0482	0.5929	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK protein kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	growth factor receptor-bound protein	0.0482	0.5929	0.5929
Brugia malayi	SH2 domain containing protein	0.0482	0.5929	0.5929
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	SRC-1	0.0798	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0317	0.3802	0.3802
Schistosoma mansoni	hypothetical protein	0.0482	0.5929	0.5929
Loa Loa (eye worm)	TK/FER protein kinase	0.0317	0.3802	0.3802
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0482	0.5929	0.5929
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0482	0.5929	0.5929
Echinococcus granulosus	tyrosine protein kinase csk	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus multilocularis	protein kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	epidermal growth factor receptor	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0798	1	1
Schistosoma mansoni	memapsin-2 (A01 family)	0.0521	0.6431	0.6431
Schistosoma mansoni	nck2/grb4	0.0482	0.5929	0.5929
Schistosoma mansoni	serine/threonine protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/FER protein kinase	0.0798	1	1
Loa Loa (eye worm)	TK protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/FER protein kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0317	0.3802	0.3802
Echinococcus granulosus	epidermal growth factor receptor	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/FER protein kinase	0.0798	1	1
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0317	0.3802	0.3802
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0317	0.3802	0.3802
Brugia malayi	SH2 domain containing protein	0.0482	0.5929	0.5929
Echinococcus granulosus	growth factor receptor bound protein 2	0.0482	0.5929	0.5929
Loa Loa (eye worm)	TK/FER protein kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	TK protein kinase	0.0317	0.3802	0.3802
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0317	0.3802	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0.3802	1
Echinococcus multilocularis	N chimaerin	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0317	0.3802	0.3802
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0482	0.5929	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0798	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0317	0.3802	0.3802
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0798	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0.3802	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK/ALK protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0482	0.5929	0.5929
Brugia malayi	Protein kinase domain containing protein	0.0317	0.3802	0.3802
Brugia malayi	SH2 domain containing protein	0.0482	0.5929	0.5929
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0798	1	1
Brugia malayi	ephrin receptor 1 precursor	0.0317	0.3802	0.3802
Brugia malayi	SH2 domain containing protein	0.0482	0.5929	0.5929
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0317	0.3802	0.3802
Onchocerca volvulus	Tyrosine kinase homolog	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	Protein kinase domain containing protein	0.0798	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0317	0.3802	0.3802
Echinococcus multilocularis	SH2 motif	0.0482	0.5929	0.5929
Echinococcus multilocularis	tensin	0.0482	0.5929	0.5929
Echinococcus multilocularis	tyrosine protein kinase csk	0.0317	0.3802	0.3802
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Plasmodium vivax	protein kinase, putative	0.0317	0.3802	1
Schistosoma mansoni	protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0482	0.5929	0.5929
Loa Loa (eye worm)	TK/FER protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	SH2 domain-containing protein	0.0482	0.5929	0.5929
Loa Loa (eye worm)	TK/DDR protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Echinococcus granulosus	c src tyrosine kinase	0.0798	1	1
Leishmania major	protein kinase, putative	0.0317	0.3802	0.5
Echinococcus granulosus	SH2 motif	0.0482	0.5929	0.5929
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0317	0.3802	0.3802
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0482	0.5929	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0482	0.5929	0.5929
Loa Loa (eye worm)	STAT protein	0.0482	0.5929	0.5929
Schistosoma mansoni	tyrosine kinase	0.0798	1	1
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Brugia malayi	SH2 domain containing protein	0.0482	0.5929	0.5929
Echinococcus multilocularis	tyrosine protein kinase csk	0.0317	0.3802	0.3802
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0482	0.5929	0.5929
Toxoplasma gondii	protein kinase domain-containing protein	0.0317	0.3802	1
Brugia malayi	protein-tyrosine kinase	0.0798	1	1
Echinococcus granulosus	tyrosine kinase	0.0317	0.3802	0.3802
Trichomonas vaginalis	AGC family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0356	0.0356
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0317	0.3802	0.3802
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0798	1	1
Loa Loa (eye worm)	TK protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	tensin	0.0482	0.5929	0.5929
Echinococcus granulosus	natriuretic peptide receptor 1	0.0317	0.3802	0.3802
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0317	0.3802	1
Onchocerca volvulus		0.0798	1	1
Schistosoma mansoni	tyrosine kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TK protein kinase	0.0317	0.3802	0.3802
Echinococcus multilocularis	FL cytokine receptor	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0317	0.3802	0.3802
Onchocerca volvulus		0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	tyrosine protein kinase Blk	0.0798	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0.3802	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0482	0.5929	0.5929
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0317	0.3802	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0798	1	1
Onchocerca volvulus		0.0482	0.5929	0.5929
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0798	1	1
Echinococcus granulosus	protein tyrosine kinase	0.0317	0.3802	0.3802
Echinococcus granulosus	epidermal growth factor receptor	0.0317	0.3802	0.3802
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0317	0.3802	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3802	0.3802
Schistosoma mansoni	ephrin receptor	0.0317	0.3802	0.3802

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.2 uM	Inhibition of BACE1-mediated soluble APPbeta release in human SH-SY5Y cells after 16 hrs	ChEMBL.	23126626
IC50 (binding)	= 7.9 uM	Inhibition of human BACE1 (1-460) using CEVNLDAEFK as substrate preincubated for 10 mins prior to substrate addition measured after 15 mins by TR-FRET assay	ChEMBL.	23126626
IC50 (binding)	= 9.2 uM	Inhibition of human ERG expressed in CHO cells	ChEMBL.	23126626
Papp (ADMET)	= 15 ucm/s	Apparent permeability from apical to basolateral side in human Caco2 cells at 10 uM after 30 to 60 mins at pH 7.4 by LC/MS analysis	ChEMBL.	23126626

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2380454

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1761073