Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | Starlite/ChEMBL | References |
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.2469 | 1 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0434 | 0.1193 | 0.1193 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0434 | 0.1193 | 0.0838 |
Trypanosoma brucei | protein kinase, putative | 0.2469 | 1 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0248 | 0.0387 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0248 | 0.0387 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2469 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.2469 | 1 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0434 | 0.1193 | 0.0135 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.2469 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.027 | 0.0483 | 0.0483 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.2469 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.2469 | 1 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0434 | 0.1193 | 0.1193 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2469 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.2469 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | extracellular metallopeptidase | 0.068 | 0.2256 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2469 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.2469 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2469 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.027 | 0.0483 | 0.0101 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0434 | 0.1193 | 0.0135 |
Echinococcus granulosus | mitogen activated protein kinase | 0.2469 | 1 | 1 |
Echinococcus granulosus | Receptor type tyrosine protein phosphatase O | 0.0718 | 0.2422 | 0.1513 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.2469 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.2469 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.2469 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2469 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2469 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2469 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.2469 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.8 uM | Inhibition of Protein-tyrosine phosphatase 1B (PTP1B) | ChEMBL. | 12951078 |
Ki (binding) | = 1.8 uM | Inhibition of Protein-tyrosine phosphatase 1B (PTP1B) | ChEMBL. | 12951078 |
Ki (binding) | = 9.3 uM | Inhibition of T-cell Protein Tyrosine Phosphatase (TCPTP) | ChEMBL. | 12951078 |
Ki (binding) | = 9.3 uM | Inhibition of T-cell Protein Tyrosine Phosphatase (TCPTP) | ChEMBL. | 12951078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.