Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.1272 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0367 | 0.1051 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1272 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.1272 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Onchocerca volvulus | 0.0367 | 0.1051 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus multilocularis | aldo keto reductase | 0.0367 | 0.1051 | 0.1051 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Onchocerca volvulus | 0.0367 | 0.1051 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.1272 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1272 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1272 | 1 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.1272 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.1272 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus multilocularis | aldo keto reductase | 0.0367 | 0.1051 | 0.1051 |
Giardia lamblia | Aldose reductase | 0.0367 | 0.1051 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1272 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0367 | 0.1051 | 0.1051 |
Entamoeba histolytica | aldose reductase, putative | 0.0367 | 0.1051 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus granulosus | aldo keto reductase | 0.0367 | 0.1051 | 0.1051 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1272 | 1 | 1 |
Onchocerca volvulus | 0.0367 | 0.1051 | 0.5 | |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0367 | 0.1051 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0367 | 0.1051 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0367 | 0.1051 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0367 | 0.1051 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0367 | 0.1051 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1272 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0367 | 0.1051 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0367 | 0.1051 | 0.1051 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus granulosus | aldo keto reductase | 0.0367 | 0.1051 | 0.1051 |
Echinococcus multilocularis | aldo keto reductase | 0.0367 | 0.1051 | 0.1051 |
Onchocerca volvulus | 0.0367 | 0.1051 | 0.5 | |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.1272 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus granulosus | aldo keto reductase | 0.0367 | 0.1051 | 0.1051 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.1272 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0367 | 0.1051 | 0.1051 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.1272 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0367 | 0.1051 | 0.1051 |
Onchocerca volvulus | 0.0367 | 0.1051 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0367 | 0.1051 | 0.1051 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.1272 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.1272 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1272 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0367 | 0.1051 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1272 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.1272 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0367 | 0.1051 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0367 | 0.1051 | 0.1051 |
Onchocerca volvulus | 0.0367 | 0.1051 | 0.5 | |
Echinococcus granulosus | hypothetical protein | 0.0367 | 0.1051 | 0.1051 |
Echinococcus multilocularis | aldo keto reductase | 0.0367 | 0.1051 | 0.1051 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 92.31 % | Antiproliferative activity against human NUGC3 cells at 0.1 uM by SRB assay | ChEMBL. | 23567950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.