Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0087 | 0.1654 | 0.1591 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.1696 | 0.1634 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 1 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0078 | 0.1259 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.027 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.027 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0088 | 0.1696 | 0.1634 |
Leishmania major | aldo-keto reductase-like protein | 0.027 | 1 | 1 |
Onchocerca volvulus | 0.027 | 1 | 1 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.027 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0078 | 0.1259 | 0.1193 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.027 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.027 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.027 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0164 | 0.5142 | 0.5142 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0088 | 0.1696 | 0.1634 |
Entamoeba histolytica | aldose reductase, putative | 0.027 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.027 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.027 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0192 | 0.6436 | 0.5922 |
Loa Loa (eye worm) | oxidoreductase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0078 | 0.1259 | 0.1193 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.027 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.027 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.027 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.1696 | 0.1634 |
Schistosoma mansoni | potassium channel beta | 0.0078 | 0.1259 | 0.1193 |
Echinococcus granulosus | aldo keto reductase | 0.027 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.027 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.027 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Onchocerca volvulus | 0.027 | 1 | 1 | |
Mycobacterium ulcerans | oxidoreductase | 0.027 | 1 | 1 |
Onchocerca volvulus | 0.027 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0052 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.027 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.027 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.027 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0192 | 0.6436 | 0.6436 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0088 | 0.1696 | 0.1696 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.027 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0052 | 0.0075 | 0.0075 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Onchocerca volvulus | 0.027 | 1 | 1 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.027 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.027 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0078 | 0.1259 | 0.5 |
Echinococcus granulosus | aldehyde reductase | 0.0192 | 0.6436 | 0.6409 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.027 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.027 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0164 | 0.5142 | 0.5106 |
Schistosoma mansoni | tyrosine kinase | 0.0087 | 0.1654 | 0.1591 |
Plasmodium vivax | aldehyde reductase, putative | 0.0078 | 0.1259 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.027 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.027 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Onchocerca volvulus | 0.027 | 1 | 1 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0164 | 0.5142 | 0.5106 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.027 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0078 | 0.1259 | 0.1193 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0087 | 0.1654 | 0.1591 |
Onchocerca volvulus | 0.027 | 1 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.027 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0164 | 0.5142 | 0.5106 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0078 | 0.1259 | 0.1193 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.027 | 1 | 1 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0078 | 0.1259 | 0.1193 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.027 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0078 | 0.1259 | 0.1259 |
Echinococcus multilocularis | aldo keto reductase | 0.027 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.027 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.027 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0078 | 0.1259 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.027 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0164 | 0.5142 | 0.5106 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 96.52 % | Antiproliferative activity against human NUGC3 cells at 0.1 uM by SRB assay | ChEMBL. | 23567950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.