Detailed information for compound 1761524

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.414 | Formula: C20H21N5O
  • H donors: 0 H acceptors: 4 LogP: 3.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(n1nnnc1Cc1ccc(cc1)c1ccccc1)N1CCCCC1
  • InChi: 1S/C20H21N5O/c26-20(24-13-5-2-6-14-24)25-19(21-22-23-25)15-16-9-11-18(12-10-16)17-7-3-1-4-8-17/h1,3-4,7-12H,2,5-6,13-15H2
  • InChiKey: DUPKAESIJQIEMA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Transient receptor potential cation channel subfamily A member 1 Starlite/ChEMBL References
Homo sapiens monoglyceride lipase Starlite/ChEMBL References
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL References
Rattus norvegicus Anandamide amidohydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis valacyclovir hydrolase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania donovani monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Brugia malayi amidase Get druggable targets OG5_127783 All targets in OG5_127783
Plasmodium vivax PST-A protein Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma japonicum ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis transient receptor potential cation channel Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni amidase Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni transient receptor potential cation channel subfamily A member Get druggable targets OG5_132409 All targets in OG5_132409
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania infantum monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus granulosus transient receptor potential cation channel Get druggable targets OG5_132409 All targets in OG5_132409
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania major monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Mycobacterium tuberculosis Possible lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus granulosus ankyrin repeat protein Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma mansoni fatty-acid amide hydrolase Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Trypanosoma cruzi monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum ko:K04984 transient receptor potential cation channel, subfamily A, member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus multilocularis ankyrin repeat protein Get druggable targets OG5_132409 All targets in OG5_132409
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Mycobacterium ulcerans lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania mexicana monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania braziliensis monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum esterase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Anandamide amidohydrolase   579 aa 539 aa 34.7 %
Echinococcus multilocularis fatty acid amide hydrolase 1 Anandamide amidohydrolase   579 aa 470 aa 28.3 %
Plasmodium falciparum esterase, putative monoglyceride lipase 303 aa 254 aa 19.7 %
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Anandamide amidohydrolase   579 aa 499 aa 24.6 %
Echinococcus granulosus fatty acid amide hydrolase 1 Anandamide amidohydrolase   579 aa 470 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.2564 0.2622
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0054 0.2564 0.2564
Brugia malayi RE15519p 0.0054 0.2564 0.415
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.4146 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0123 0.6178 0.6317
Trypanosoma brucei monoglyceride lipase, putative 0.0084 0.4146 1
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.2564 0.2568
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0517 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.2564 0.2622
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0084 0.4146 1
Echinococcus multilocularis orexin receptor type 2 0.0054 0.2564 0.2564
Schistosoma mansoni adenoreceptor 0.0054 0.2564 0.2622
Brugia malayi larval opioid receptor 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Brugia malayi hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.2564 0.2564
Loa Loa (eye worm) TYRA-2 protein 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0005 0 0.5
Onchocerca volvulus 0.0054 0.2564 0.5
Plasmodium falciparum lysophospholipase, putative 0.0084 0.4146 1
Schistosoma mansoni hypothetical protein 0.0054 0.2564 0.2622
Echinococcus granulosus serotonin receptor 0.0054 0.2564 0.2568
Toxoplasma gondii hypothetical protein 0.0005 0 0.5
Echinococcus granulosus orexin receptor type 2 0.0054 0.2564 0.2568
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.2564 0.2568
Schistosoma mansoni neuropeptide f receptor 76f 0.0054 0.2564 0.2622
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Leishmania major monoglyceride lipase, putative 0.0084 0.4146 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0054 0.2564 0.2622
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.2564 0.2564
Brugia malayi AKH receptor 0.0054 0.2564 0.415
Brugia malayi hypothetical protein 0.0054 0.2564 0.415
Echinococcus granulosus g protein coupled receptor 0.0054 0.2564 0.2568
Brugia malayi amidase 0.0123 0.6178 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis g protein coupled receptor 0.0054 0.2564 0.2564
Toxoplasma gondii phospholipase/carboxylesterase 0.0005 0 0.5
Brugia malayi putative neuropeptide receptor 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0054 0.2564 0.2568
Schistosoma mansoni hypothetical protein 0.0054 0.2564 0.2622
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Onchocerca volvulus 0.0054 0.2564 0.5
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0517 0.0528
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Onchocerca volvulus 0.0054 0.2564 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0054 0.2564 0.2568
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.6178 0.6188
Echinococcus granulosus peptide allatostatin:somatostatin 0.0054 0.2564 0.2568
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.2564 0.2564
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.2564 0.2564
Mycobacterium ulcerans hypothetical protein 0.0084 0.4146 1
Onchocerca volvulus 0.0054 0.2564 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.2564 0.2622
Brugia malayi putative amidase 0.0015 0.0517 0.0837
Echinococcus multilocularis neuropeptide receptor A26 0.0054 0.2564 0.2564
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Schistosoma mansoni amine GPCR 0.0054 0.2564 0.2622
Echinococcus multilocularis fmrfamide receptor 0.0054 0.2564 0.2564
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.2564 0.2622
Echinococcus multilocularis g protein coupled receptor 0.0054 0.2564 0.2564
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.2564 0.2622
Mycobacterium ulcerans amidase 0.0015 0.0517 0.1247
Echinococcus granulosus g protein coupled receptor 0.0054 0.2564 0.2568
Echinococcus granulosus hypothetical protein 0.0054 0.2564 0.2568
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0192 0.978 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.4146 1
Echinococcus granulosus g protein coupled receptor 0.0054 0.2564 0.2568
Plasmodium falciparum lysophospholipase, putative 0.0084 0.4146 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.4146 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Mycobacterium ulcerans amidase 0.0015 0.0517 0.1247
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis neuropeptide receptor 0.0054 0.2564 0.2564
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.2564 0.2564
Brugia malayi hypothetical protein 0.0054 0.2564 0.415
Mycobacterium tuberculosis Possible lysophospholipase 0.0084 0.4146 1
Schistosoma mansoni amidase 0.0123 0.6178 0.6317
Echinococcus granulosus neuropeptide receptor 0.0054 0.2564 0.2568
Brugia malayi G protein-coupled receptor F59B2.13 0.0054 0.2564 0.415
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.2564 0.2622
Trypanosoma cruzi amidase, putative 0.0015 0.0517 0.1247
Toxoplasma gondii protein c14orf29, putative 0.0005 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Toxoplasma gondii peptidase S15, putative 0.0005 0 0.5
Echinococcus granulosus somatostatin receptor 0.0054 0.2564 0.2568
Leishmania major hypothetical protein, conserved 0.0005 0.00000021058 0.00000050795
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0015 0.0517 0.1247
Mycobacterium ulcerans amidase 0.0015 0.0517 0.1247
Onchocerca volvulus 0.0054 0.2564 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0054 0.2564 0.2622
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0015 0.0517 0.1247
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0054 0.2564 0.415
Toxoplasma gondii hypothetical protein 0.0005 0 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0054 0.2564 0.2564
Brugia malayi Dopamine receptor 0.0054 0.2564 0.415
Onchocerca volvulus 0.0054 0.2564 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0054 0.2564 0.2568
Echinococcus multilocularis serotonin receptor 0.0054 0.2564 0.2564
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.2564 0.2622
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0054 0.2564 0.415
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0054 0.2564 0.2564
Brugia malayi ORL1-like opioid receptor 0.0054 0.2564 0.415
Schistosoma mansoni neuropeptide receptor 0.0054 0.2564 0.2622
Schistosoma mansoni hypothetical protein 0.0054 0.2564 0.2622
Loa Loa (eye worm) hypothetical protein 0.0123 0.6178 1
Onchocerca volvulus 0.0054 0.2564 0.5
Brugia malayi hypothetical protein 0.0054 0.2564 0.415
Echinococcus granulosus neuropeptide receptor A26 0.0054 0.2564 0.2568
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.2564 0.2564
Mycobacterium ulcerans lysophospholipase 0.0084 0.4146 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.2564 0.2622
Brugia malayi Amidase family protein 0.0015 0.0517 0.0837
Trypanosoma brucei monoglyceride lipase, putative 0.0084 0.4146 1
Toxoplasma gondii phospholipase 0.0005 0 0.5
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0084 0.4146 1
Brugia malayi hypothetical protein 0.0054 0.2564 0.415
Brugia malayi neuropeptide F receptor 0.0054 0.2564 0.415
Echinococcus granulosus fatty acid amide hydrolase 1 0.0015 0.0517 0.0518
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.2564 0.2564
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0054 0.2564 0.415
Brugia malayi hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0054 0.2564 0.2564
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.2564 0.2568
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.4146 1
Mycobacterium ulcerans amidase 0.0015 0.0517 0.1247
Brugia malayi G-protein coupled receptor 0.0054 0.2564 0.415
Toxoplasma gondii hypothetical protein 0.0005 0 0.5
Echinococcus granulosus allatostatin A receptor 0.0054 0.2564 0.2568
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Schistosoma mansoni biogenic amine receptor 0.0054 0.2564 0.2622
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0084 0.4146 1
Brugia malayi hypothetical protein 0.0054 0.2564 0.415
Echinococcus granulosus sex peptide receptor 0.0054 0.2564 0.2568
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0517 1
Brugia malayi Dopamine receptor protein 2 0.0054 0.2564 0.415
Brugia malayi sulfakinin receptor protein 0.0054 0.2564 0.415
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0054 0.2564 0.415
Toxoplasma gondii hypothetical protein 0.0005 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.2564 0.415
Schistosoma mansoni amine GPCR 0.0054 0.2564 0.2622
Schistosoma mansoni biogenic amine receptor 0.0054 0.2564 0.2622
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis g protein coupled receptor 0.0054 0.2564 0.2564
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0054 0.2564 0.2564
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.2564 0.2622
Brugia malayi neuropeptide F receptor 0.0054 0.2564 0.415
Loa Loa (eye worm) amidase 0.0015 0.0517 0.0837
Brugia malayi hypothetical protein 0.0054 0.2564 0.415
Echinococcus granulosus G protein coupled receptor 139 0.0054 0.2564 0.2568
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.2564 0.2568
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0054 0.2564 0.2622
Echinococcus multilocularis fmrfamide receptor 0.0054 0.2564 0.2564
Loa Loa (eye worm) melatonin receptor type 1A 0.0054 0.2564 0.415
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.2564 0.2568
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.6178 0.6178
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.4146 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.2564 0.2622
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0054 0.2564 0.415
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.6178 0.6188
Onchocerca volvulus 0.0054 0.2564 0.5
Onchocerca volvulus 0.0054 0.2564 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.2564 0.2568
Plasmodium vivax PST-A protein 0.0084 0.4146 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.2564 0.2622
Onchocerca volvulus 0.0054 0.2564 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.2564 0.2622
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.2564 0.2568
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0015 0.0517 0.0518
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.2564 0.2568
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0015 0.0517 0.1247
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.2564 0.2564
Brugia malayi Dopamine receptor protein 1 0.0054 0.2564 0.415
Onchocerca volvulus 0.0054 0.2564 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0054 0.2564 0.2564
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.2564 0.2564
Onchocerca volvulus 0.0054 0.2564 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0054 0.2564 0.2564
Loa Loa (eye worm) amidase 0.0015 0.0517 0.0837
Echinococcus multilocularis neuropeptide receptor 0.0054 0.2564 0.2564
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.2564 0.2622
Schistosoma mansoni amine GPCR 0.0054 0.2564 0.2622
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.6178 0.6178
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0054 0.2564 0.2622
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0517 0.1247
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.2564 0.2568
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0005 0 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0054 0.2564 0.2564
Echinococcus multilocularis G protein coupled receptor 139 0.0054 0.2564 0.2564
Echinococcus granulosus 7tm_1 domain containing protein 0.0054 0.2564 0.2568
Brugia malayi G-protein coupled receptor 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Schistosoma mansoni neuropeptide receptor 0.0054 0.2564 0.2622
Brugia malayi putative neuropeptide receptor NPR1 0.0054 0.2564 0.415
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0015 0.0517 0.1247
Plasmodium falciparum lysophospholipase, putative 0.0084 0.4146 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.2564 0.2568
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.2564 0.2568
Mycobacterium ulcerans amidase 0.0015 0.0517 0.1247
Echinococcus granulosus transient receptor potential cation channel 0.0196 0.9985 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Schistosoma mansoni amine GPCR 0.0054 0.2564 0.2622
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.2564 0.2564
Brugia malayi hypothetical protein 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis dro:myosuppressin receptor 0.0054 0.2564 0.2564
Echinococcus multilocularis ankyrin repeat protein 0.0192 0.978 0.978
Echinococcus granulosus ankyrin repeat protein 0.0192 0.978 0.9795
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0054 0.2564 0.2568
Brugia malayi hypothetical protein 0.0054 0.2564 0.415
Echinococcus granulosus alpha 1A adrenergic receptor 0.0054 0.2564 0.2568
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.2564 0.415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.2564 0.2564
Brugia malayi Serotonin receptor 0.0054 0.2564 0.415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.2564 0.2622
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0015 0.0517 0.1247
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.2564 0.2564
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0054 0.2564 0.415
Brugia malayi Serotonin receptor 0.0054 0.2564 0.415
Echinococcus multilocularis allatostatin A receptor 0.0054 0.2564 0.2564
Brugia malayi Tachykinin-like peptides receptor 99D 0.0054 0.2564 0.415
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.2564 0.2568
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0054 0.2564 0.2622
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0054 0.2564 0.415
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.2564 0.2622
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0054 0.2564 0.2622
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0054 0.2564 0.415
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0015 0.0517 0.1247
Schistosoma mansoni opsin-like receptor 0.0054 0.2564 0.2622
Echinococcus granulosus fmrfamide receptor 0.0054 0.2564 0.2568
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus granulosus dro:myosuppressin receptor 0.0054 0.2564 0.2568
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.2564 0.2564
Echinococcus granulosus tachykinin peptides receptor 99D 0.0054 0.2564 0.2568
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis somatostatin receptor 0.0054 0.2564 0.2564
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0517 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Schistosoma mansoni neuropeptide receptor 0.0054 0.2564 0.2622
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.2564 0.2564
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0005 0 0.5
Trypanosoma cruzi monoglyceride lipase, putative 0.0084 0.4146 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0054 0.2564 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis sex peptide receptor 0.0054 0.2564 0.2564
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.2564 0.2622
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.2564 0.415
Schistosoma mansoni amine GPCR 0.0054 0.2564 0.2622
Schistosoma mansoni opsin-like receptor 0.0054 0.2564 0.2622
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0015 0.0517 0.0517
Echinococcus granulosus neuropeptide s receptor 0.0054 0.2564 0.2568
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.2564 0.2564
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.2564 0.2564
Echinococcus granulosus neuropeptide FF receptor 2 0.0054 0.2564 0.2568
Leishmania major hypothetical protein, conserved 0.0015 0.0517 0.1247
Echinococcus granulosus neuropeptide receptor 0.0054 0.2564 0.2568
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0015 0.0517 0.1247
Onchocerca volvulus 0.0054 0.2564 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0054 0.2564 0.2564
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Brugia malayi Melatonin receptor type 1A 0.0054 0.2564 0.415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.2564 0.2622
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Trypanosoma cruzi amidase, putative 0.0015 0.0517 0.1247
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0005 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.2564 0.2568
Echinococcus granulosus 7TM GPCR rhodopsin 0.0054 0.2564 0.2568
Plasmodium falciparum esterase, putative 0.0084 0.4146 1
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.4146 1
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0517 0.1247
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.2564 0.2568
Brugia malayi GnHR receptor homolog 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Brugia malayi Amidase family protein 0.0015 0.0517 0.0837
Schistosoma mansoni fatty-acid amide hydrolase 0.0015 0.0517 0.0528
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.2564 0.2568
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0054 0.2564 0.2622
Onchocerca volvulus Neuropeptide F receptor homolog 0.0054 0.2564 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0054 0.2564 0.415
Echinococcus multilocularis G-protein coupled receptor, putative 0.0054 0.2564 0.2564
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0054 0.2564 0.2622
Schistosoma mansoni growth hormone secretagogue receptor 0.0054 0.2564 0.2622
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0054 0.2564 0.2564
Onchocerca volvulus 0.0054 0.2564 0.5
Mycobacterium ulcerans peptide amidase, GatA 0.0015 0.0517 0.1247
Onchocerca volvulus 0.0054 0.2564 0.5
Onchocerca volvulus 0.0054 0.2564 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0084 0.4146 1
Schistosoma mansoni myosin xvIII 0.0054 0.2564 0.2622
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.4146 1
Schistosoma mansoni histamine h1 receptor 0.0054 0.2564 0.2622
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Brugia malayi G protein-coupled receptor 0.0054 0.2564 0.415
Echinococcus granulosus g-protein coupled receptor 0.0054 0.2564 0.2568
Echinococcus multilocularis neuropeptide s receptor 0.0054 0.2564 0.2564
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.2564 0.415
Onchocerca volvulus 0.0054 0.2564 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0054 0.2564 0.2622
Echinococcus multilocularis g-protein coupled receptor 0.0054 0.2564 0.2564
Brugia malayi follicle stimulating hormone receptor 0.0054 0.2564 0.415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.2564 0.2622
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Echinococcus multilocularis serotonin receptor 0.0054 0.2564 0.2564
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0015 0.0517 0.0517
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.2564 0.2568
Schistosoma mansoni neuropeptide receptor 0.0054 0.2564 0.2622
Schistosoma mansoni hypothetical protein 0.0054 0.2564 0.2622
Schistosoma mansoni opsin-like receptor 0.0054 0.2564 0.2622
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.2564 0.2564
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415
Schistosoma mansoni biogenic amine receptor 0.0054 0.2564 0.2622
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.2564 0.2568
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.2564 0.2568
Loa Loa (eye worm) hypothetical protein 0.0054 0.2564 0.415

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 5.9 uM Agonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric analysis ChEMBL. 23474898
EC50 (binding) = 6.5 uM Agonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric analysis ChEMBL. 23474898
Efficacy (binding) = 67.4 % Agonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric analysis relative to ionomycin ChEMBL. 23474898
Efficacy (binding) = 106.5 % Agonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric analysis relative to allyl isothiocyanate ChEMBL. 23474898
IC50 (binding) = 38.2 nM Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis ChEMBL. 23474898
IC50 (binding) > 1000 nM Inhibition of MAGL (unknown origin) expressed in African green monkey COS7 cell cytosolic fraction assessed as [3H]2-AG hydrolysis to [3H]arachidonic acid after 20 mins by beta counting analysis ChEMBL. 23474898
IC50 (binding) = 12.5 uM Antagonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular Ca2+ elevation incubated for 5 mins prior to allyl isothiocyanate-stimulation by spectrofluorimetric analysis ChEMBL. 23474898
IC50 (binding) = 22.6 uM Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ elevation incubated for 5 mins prior to capsaicin-stimulation by spectrofluorimetric analysis ChEMBL. 23474898

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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