TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 365.386 | Formula: C19H19N5O3
H donors: 0 H acceptors: 5 LogP: 2.89 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1cccc(c1)c1ccc(cc1)Cc1nnnn1C(=O)N(C)C
InChi: 1S/C19H19N5O3/c1-23(2)19(26)24-17(20-21-22-24)11-13-7-9-14(10-8-13)15-5-4-6-16(12-15)18(25)27-3/h4-10,12H,11H2,1-3H3
InChiKey: NMVMWJKPAIJGFT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Anandamide amidohydrolase	Starlite/ChEMBL	References
Homo sapiens	monoglyceride lipase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania mexicana	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Leishmania infantum	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	valacyclovir hydrolase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania major	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Brugia malayi	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Leishmania braziliensis	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma cruzi	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Schistosoma mansoni	fatty-acid amide hydrolase	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	esterase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium tuberculosis	Possible lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Schistosoma japonicum	ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative	Get druggable targets OG5_127783	All targets in OG5_127783
Leishmania donovani	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium vivax	PST-A protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.7 %
Echinococcus multilocularis	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.3 %
Onchocerca volvulus		Anandamide amidohydrolase	579 aa	539 aa	34.7 %
Plasmodium falciparum	esterase, putative	monoglyceride lipase	303 aa	254 aa	19.7 %
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Anandamide amidohydrolase	579 aa	499 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	esterase, putative	0.0084	0.4475	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0592	0.0608
Schistosoma mansoni	phd/f-box containing protein	0.0025	0.0562	0.0425
Echinococcus granulosus	JmjC domain containing protein 4	0.0025	0.0562	0.0425
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0462	0.0735
Brugia malayi	jmjC domain containing protein	0.0025	0.0562	0.0622
Schistosoma mansoni	jumonji domain containing protein	0.0025	0.0562	0.0425
Echinococcus granulosus	phd:f box containing protein	0.0025	0.0562	0.0425
Schistosoma mansoni	hypothetical protein	0.0168	1	1
Loa Loa (eye worm)	RNA binding protein	0.0127	0.7294	0.8445
Echinococcus multilocularis	lysine specific demethylase 5A	0.0093	0.5073	0.5001
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0592	0.1036
Plasmodium vivax	JmjC domain containing protein	0.0025	0.0562	0.1112
Loa Loa (eye worm)	jmjC domain-containing protein	0.0093	0.5073	0.5848
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0025	0.0562	0.0425
Schistosoma mansoni	amidase	0.0123	0.7037	0.6994
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0143	0.0161
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0127	0.7294	0.8445
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.0562	0.0573
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0462	0.0735
Echinococcus granulosus	lysine specific demethylase 6a	0.0025	0.0562	0.0425
Echinococcus multilocularis	lysine specific demethylase 6a	0.0025	0.0562	0.0425
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0462	0.0884
Echinococcus granulosus	jumonji domain containing 1A	0.0025	0.0562	0.0425
Entamoeba histolytica	hypothetical protein	0.0072	0.3677	0.8156
Entamoeba histolytica	hypothetical protein	0.0072	0.3677	0.8156
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0084	0.4475	1
Schistosoma mansoni	hypothetical protein	0.0029	0.0843	0.071
Entamoeba histolytica	hypothetical protein	0.0072	0.3677	0.8156
Brugia malayi	jmjC domain containing protein	0.0025	0.0562	0.0622
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0123	0.7037	0.6994
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0592	0.118
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0123	0.7037	0.6994
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0084	0.4475	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0143	0.0161
Loa Loa (eye worm)	TAR-binding protein	0.0127	0.7294	0.8445
Mycobacterium ulcerans	lysophospholipase	0.0084	0.4475	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0562	0.0573
Echinococcus multilocularis	JmjC domain containing protein 4	0.0025	0.0562	0.0425
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0462	0.0735
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.3677	0.3585
Schistosoma mansoni	hypothetical protein	0.0168	1	1
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0025	0.0562	0.5984
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.3677	0.3585
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0025	0.0562	0.0425
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0143	0.0161
Echinococcus granulosus	muscleblind protein	0.0147	0.8624	0.8604
Plasmodium vivax	PST-A protein	0.0084	0.4475	1
Brugia malayi	amidase	0.0123	0.7037	0.7784
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0093	0.5073	0.5001
Brugia malayi	RNA binding protein	0.0127	0.7294	0.8068
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0153	0.904	0.9026
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0592	0.1036
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0843	0.0901
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.4475	1
Brugia malayi	jmjC domain containing protein	0.0025	0.0562	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0843	0.0901
Giardia lamblia	PHD finger protein 15	0.0029	0.0843	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.4475	1
Schistosoma mansoni	fatty-acid amide hydrolase	0.0123	0.7037	0.6994
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0462	0.0511
Schistosoma mansoni	protein phosphatase 2C	0.0025	0.0562	0.0425
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0592	0.6409
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0025	0.0562	0.5984
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0592	0.1036
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0843	0.1751
Brugia malayi	jmjC domain containing protein	0.0025	0.0562	0.0622
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0143	0.5
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0462	0.0884
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0123	0.7037	0.6994
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0143	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0127	0.7294	0.7254
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.7294	0.7254
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.1596	0.1474
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0143	0.0159
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.0562	0.0573
Echinococcus multilocularis	muscleblind protein 1	0.0147	0.8624	0.8604
Loa Loa (eye worm)	hypothetical protein	0.0123	0.7037	0.8145
Brugia malayi	TAR-binding protein	0.0127	0.7294	0.8068
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0462	0.0735
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0462	0.0735
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0153	0.904	0.9026
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0843	0.1751
Loa Loa (eye worm)	hypothetical protein	0.0065	0.3236	0.37
Trypanosoma cruzi	monoglyceride lipase, putative	0.0084	0.4475	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.4475	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0093	0.5073	0.5001
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0592	0.118
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0462	0.1012
Echinococcus granulosus	peregrin	0.0029	0.0843	0.071
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.0562	0.0573
Brugia malayi	jmjC domain containing protein	0.0093	0.5073	0.5612
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0462	0.0455
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0843	0.071
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0025	0.0562	0.1112
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.4475	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.4475	1
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0025	0.0562	0.0425
Leishmania major	hypothetical protein, conserved	0.0025	0.0592	0.1036
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0462	0.0884
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0462	0.0735
Leishmania major	hypothetical protein, conserved	0.0025	0.0562	0.0967
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0843	0.071
Echinococcus multilocularis	phd:f box containing protein	0.0025	0.0562	0.0425
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0143	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.4475	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0843	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.8624	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0562	0.0573
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0123	0.7037	0.6994
Echinococcus multilocularis	jumonji domain containing 1A	0.0025	0.0562	0.0425
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0462	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0462	0.0455
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.4475	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0462	0.0884
Onchocerca volvulus	Alhambra homolog	0.0029	0.0843	1
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.1596	0.1474
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0025	0.0562	0.0967
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.3677	0.3585
Trypanosoma brucei	monoglyceride lipase, putative	0.0084	0.4475	1
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0025	0.0562	0.0967
Brugia malayi	hypothetical protein	0.0072	0.3677	0.4067
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0084	0.4475	1
Brugia malayi	jmjC domain containing protein	0.0153	0.904	1
Trypanosoma brucei	monoglyceride lipase, putative	0.0084	0.4475	1
Brugia malayi	Muscleblind-like protein	0.0147	0.8624	0.9539
Brugia malayi	PHD-finger family protein	0.0029	0.0843	0.0933
Echinococcus multilocularis	peregrin	0.0029	0.0843	0.071
Schistosoma mansoni	phosphatidylserine receptor	0.0025	0.0562	0.0425
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.7294	0.7254
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0025	0.0562	0.0967
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0462	0.0884
Schistosoma mansoni	jumonji domain containing protein	0.0134	0.7747	0.7714
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0462	0.0884
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0084	0.4475	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0093	0.5073	0.5001
Entamoeba histolytica	hypothetical protein	0.0072	0.3677	0.8156
Echinococcus multilocularis	muscleblind protein	0.0147	0.8624	0.8604
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.2889	0.3294
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0072	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.7294	0.7254
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.7294	0.7254
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.4475	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0462	0.0455
Leishmania major	monoglyceride lipase, putative	0.0084	0.4475	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0592	0.118
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0462	0.0511
Schistosoma mansoni	hypothetical protein	0.0072	0.3677	0.3585
Mycobacterium tuberculosis	Possible lysophospholipase	0.0084	0.4475	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0462	0.1012
Brugia malayi	hypothetical protein	0.0025	0.0592	0.0655
Brugia malayi	RNA recognition motif domain containing protein	0.0127	0.7294	0.8068
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0462	0.0884
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.7294	0.7254
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0072	0.0141
Brugia malayi	Bromodomain containing protein	0.0029	0.0843	0.0933
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0843	0.071
Mycobacterium ulcerans	hypothetical protein	0.0084	0.4475	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.8624	1
Echinococcus granulosus	tar DNA binding protein	0.0127	0.7294	0.7254
Echinococcus multilocularis	geminin	0.0168	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.4475	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0462	0.0511
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0843	1
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.4475	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0143	0.0299

Activities

Activity type	Activity value	Assay description	Source	Reference
Efficacy (binding)	< 10 %	Agonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric analysis relative to allyl isothiocyanate	ChEMBL.	23474898
Efficacy (binding)	< 10 %	Agonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric analysis relative to ionomycin	ChEMBL.	23474898
IC50 (binding)	= 12.1 nM	Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis	ChEMBL.	23474898
IC50 (binding)	> 1000 nM	Inhibition of MAGL (unknown origin) expressed in African green monkey COS7 cell cytosolic fraction assessed as [3H]2-AG hydrolysis to [3H]arachidonic acid after 20 mins by beta counting analysis	ChEMBL.	23474898
IC50 (binding)	= 99.8 uM	Antagonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular Ca2+ elevation incubated for 5 mins prior to allyl isothiocyanate-stimulation by spectrofluorimetric analysis	ChEMBL.	23474898
IC50 (binding)	> 100 uM	Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ elevation incubated for 5 mins prior to capsaicin-stimulation by spectrofluorimetric analysis	ChEMBL.	23474898

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2376860

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1761528