Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.0004 | 0 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0306 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0306 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0306 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0306 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0306 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0306 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0306 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0306 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0306 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.000000066612 | 0.000000066612 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0306 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0.000000066612 | 0.000000066612 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0306 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0.000000066612 | 0.000000066612 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0306 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0306 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.000000066612 | 0.000000066612 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0306 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0306 | 1 | 1 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0.000000066612 | 0.000000066612 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0007 | 0.0092 | 0.0092 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0306 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0306 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.000000066612 | 0.000000066612 |
Brugia malayi | olfactory channel protein osm-9 | 0.0004 | 0.000000066612 | 0.000000066612 |
Onchocerca volvulus | 0.0004 | 0 | 0.5 | |
Echinococcus granulosus | calcium activated potassium channel | 0.0007 | 0.0092 | 0.0092 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0306 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0306 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0.000000066612 | 0.000000066612 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.000000066612 | 0.000000066612 |
Trypanosoma brucei | protein kinase, putative | 0.0306 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.000000066612 | 0.000000066612 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0.000000066612 | 0.000000066612 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.000000066612 | 0.000000066612 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | Antagonist activity at human TRPV1 transfected in CHOK1 cells assessed as inhibition of capsaicin-induced intracellular calcium level measured for 120 secs by FLIPR analysis | ChEMBL. | 23632270 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.