TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.863 | Formula: C19H21ClN6O
H donors: 3 H acceptors: 3 LogP: 2.9 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N[C@@H]1CC[C@H](CC1)Nc1ncc(n2c1nc(c2)c1ccc(cc1)Cl)C(=O)N
InChi: 1S/C19H21ClN6O/c20-12-3-1-11(2-4-12)15-10-26-16(17(22)27)9-23-18(19(26)25-15)24-14-7-5-13(21)6-8-14/h1-4,9-10,13-14H,5-8,21H2,(H2,22,27)(H,23,24)/t13-,14-
InChiKey: DIVVQJIIRBQSMU-HDJSIYSDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	casein kinase 1, delta	Starlite/ChEMBL	References
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	Janus kinase 2	Starlite/ChEMBL	References
Homo sapiens	checkpoint kinase 1	Starlite/ChEMBL	References
Homo sapiens	insulin-like growth factor 1 receptor	Starlite/ChEMBL	References
Homo sapiens	interleukin-1 receptor-associated kinase 4	Starlite/ChEMBL	References
Homo sapiens	testis-specific serine kinase 2	Starlite/ChEMBL	References
Homo sapiens	mitogen-activated protein kinase-activated protein kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Trypanosoma cruzi	casein kinase, delta isoform, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	casein kinase I delta	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma cruzi	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Trichomonas vaginalis	CK1 family protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma congolense	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Giardia lamblia	Kinase, CK1 Casein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Brugia malayi	casein kinase 1, delta	Get druggable targets OG5_126780	All targets in OG5_126780
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Trichomonas vaginalis	CK1 family protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	Casein kinase I isoform delta, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Plasmodium falciparum	casein kinase 1	Get druggable targets OG5_126780	All targets in OG5_126780
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	Get druggable targets OG5_130454	All targets in OG5_130454
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131212	All targets in OG5_131212
Echinococcus granulosus	casein kinase I delta	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania braziliensis	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Babesia bovis	casein kinase I, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130454	All targets in OG5_130454
Schistosoma mansoni	protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Onchocerca volvulus		Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma brucei gambiense	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	ko:K04527 insulin receptor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Trypanosoma cruzi	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	casein kinase i	Get druggable targets OG5_126780	All targets in OG5_126780
Entamoeba histolytica	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Brugia malayi	map kinase activated protein kinase protein 2	Get druggable targets OG5_131483	All targets in OG5_131483
Echinococcus multilocularis	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Neospora caninum	AFL091Wp, related	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	casein kinase I delta	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma brucei	casein kinase I, isoform 2	Get druggable targets OG5_126780	All targets in OG5_126780
Candida albicans	Casein kinase I: DNA repair, meiosis	Get druggable targets OG5_126780	All targets in OG5_126780
Cryptosporidium hominis	casein kinase i	Get druggable targets OG5_126780	All targets in OG5_126780
Onchocerca volvulus		Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Cryptosporidium parvum	casein kinase I	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Trichomonas vaginalis	CK1 family protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Plasmodium vivax	casein kinase 1, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	casein kinase I delta	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma cruzi	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma cruzi	casein kinase, delta isoform, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Candida albicans	Casein kinase I: DNA repair, meiosis	Get druggable targets OG5_126780	All targets in OG5_126780
Entamoeba histolytica	casein kinase 1, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131212	All targets in OG5_131212
Plasmodium knowlesi	casein kinase 1, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131212	All targets in OG5_131212
Leishmania donovani	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania mexicana	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Loa Loa (eye worm)	CAMK/TSSK protein kinase	Get druggable targets OG5_131212	All targets in OG5_131212
Toxoplasma gondii	casein kinase I	Get druggable targets OG5_126780	All targets in OG5_126780
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	CAMK/TSSK protein kinase	Get druggable targets OG5_131212	All targets in OG5_131212
Plasmodium berghei	casein kinase 1, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	casein kinase i	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma congolense	casein kinase I, isoform 2	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	ko:K08959 casein kinase 1, delta, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_130454	All targets in OG5_130454
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	ko:K02218 casein kinase 1, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483
Trypanosoma cruzi	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Schistosoma japonicum	ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative	Get druggable targets OG5_129857	All targets in OG5_129857
Leishmania infantum	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	Serine/threonine-protein kinase Chk1, putative	Get druggable targets OG5_130454	All targets in OG5_130454
Echinococcus multilocularis	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Theileria parva	casein kinase I, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Loa Loa (eye worm)	TK/INSR protein kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Leishmania major	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative	Get druggable targets OG5_131483	All targets in OG5_131483
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Trypanosoma cruzi	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Plasmodium yoelii	casein kinase i	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	casein kinase I	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	serine threonine protein kinase sik	testis-specific serine kinase 2	358 aa	336 aa	27.1 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase-activated protein kinase 2	370 aa	303 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	O-methyltransferase family protein	0.006	0.008	0.0083
Brugia malayi	RhoGAP domain containing protein	0.0066	0.0125	0.013
Echinococcus granulosus	epidermal growth factor receptor	0.0087	0.029	0.029
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0117	0.0531	0.0551
Onchocerca volvulus		0.006	0.008	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.003	0.003
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.003	0.003
Schistosoma mansoni	tyrosine kinase	0.0071	0.0165	0.0165
Schistosoma mansoni	serine/threonine protein kinase	0.1313	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0066	0.0125	0.0127
Brugia malayi	O-methyltransferase family protein	0.006	0.008	0.0083
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0301	0.199	0.199
Schistosoma mansoni	vav2	0.0066	0.0125	0.0125
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0117	0.0531	0.0551
Echinococcus multilocularis	N chimaerin	0.0066	0.0125	0.0125
Brugia malayi	Protein kinase domain containing protein	0.0204	0.1219	0.1264
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0343	0.2319	0.2349
Echinococcus granulosus	N chimaerin	0.0066	0.0125	0.0125
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0087	0.029	0.0294
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.003	0.003
Schistosoma mansoni	hypothetical protein	0.008	0.0238	0.0238
Loa Loa (eye worm)	raf kinase	0.1297	0.9874	1
Schistosoma mansoni	serine/threonine protein kinase	0.0219	0.1341	0.1341
Onchocerca volvulus		0.006	0.008	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0066	0.0125	0.0125
Brugia malayi	Raf kinase	0.1267	0.964	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0693	0.5096	0.5096
Schistosoma mansoni	o-methyltransferase	0.006	0.008	0.008
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0066	0.0125	0.0125
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0117	0.0531	0.0538
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0219	0.1341	0.1358
Brugia malayi	Protein kinase domain containing protein	0.0102	0.0413	0.0429
Schistosoma mansoni	tyrosine kinase	0.0173	0.0973	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0531	0.0538
Schistosoma mansoni	tyrosine kinase	0.0087	0.029	0.029
Schistosoma mansoni	tyrosine kinase	0.0173	0.0973	0.0973
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0748	0.5531	0.5602
Brugia malayi	Protein kinase domain containing protein	0.0343	0.2319	0.2406
Loa Loa (eye worm)	hypothetical protein	0.008	0.0238	0.0241
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0693	0.5096	0.5096
Schistosoma mansoni	tyrosine kinase	0.0071	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0343	0.2319	0.2349
Echinococcus granulosus	insulin receptor	0.0173	0.0973	0.0973
Schistosoma mansoni	o-methyltransferase	0.006	0.008	0.008
Brugia malayi	map kinase activated protein kinase protein 2	0.0219	0.1341	0.1391
Schistosoma mansoni	o-methyltransferase	0.006	0.008	0.008
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.003	0.003
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.003	0.003
Mycobacterium ulcerans	O-methyltransferase	0.0578	0.4184	1
Mycobacterium tuberculosis	Probable catechol-O-methyltransferase	0.0518	0.3709	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0288	0.0292
Brugia malayi	Tyrosine-protein kinase abl-1	0.0406	0.282	0.2925
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0066	0.0125	0.0125
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0219	0.1341	0.1341
Loa Loa (eye worm)	O-methyltransferase	0.006	0.008	0.0081
Schistosoma mansoni	serine/threonine protein kinase	0.0204	0.1219	0.1219
Schistosoma mansoni	tyrosine kinase	0.0673	0.4936	0.4936
Brugia malayi	Furin-like cysteine rich region family protein	0.0087	0.029	0.0301
Schistosoma mansoni	tyrosine kinase	0.0071	0.0165	0.0165
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0267	0.1721	0.1743
Brugia malayi	Protein kinase domain containing protein	0.0173	0.0973	0.1009
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0066	0.0125	0.0125
Brugia malayi	latrophilin 2 splice variant baaae	0.008	0.0238	0.0247
Schistosoma mansoni	tyrosine kinase	0.0087	0.029	0.029
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0087	0.029	0.029
Brugia malayi	Tyrosine-protein kinase abl-1	0.0301	0.199	0.2064
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0173	0.0973	0.0973
Echinococcus multilocularis	raf serine:threonine protein kinase	0.1313	1	1
Wolbachia endosymbiont of Brugia malayi	O-methyltransferase	0.006	0.008	0.5
Brugia malayi	O-methyltransferase	0.006	0.008	0.0083
Echinococcus multilocularis	epidermal growth factor receptor	0.0087	0.029	0.029
Schistosoma mansoni	o-methyltransferase	0.006	0.008	0.008
Brugia malayi	Variant SH3 domain containing protein	0.0066	0.0125	0.013
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0343	0.2319	0.2349
Echinococcus multilocularis	insulin receptor	0.0173	0.0973	0.0973
Schistosoma mansoni	tyrosine kinase	0.0087	0.029	0.029
Loa Loa (eye worm)	TK/ABL protein kinase	0.0693	0.5096	0.5161
Echinococcus granulosus	epidermal growth factor receptor	0.0087	0.029	0.029
Loa Loa (eye worm)	hypothetical protein	0.006	0.008	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0343	0.2319	0.2406
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.003	0.003
Brugia malayi	O-methyltransferase family protein	0.006	0.008	0.0083
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.003	0.0031
Echinococcus multilocularis	epidermal growth factor receptor	0.0087	0.029	0.029
Loa Loa (eye worm)	TK/INSR protein kinase	0.0173	0.0973	0.0985
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0052	0.0018	0.0018
Mycobacterium leprae	PROBABLE METHYLTRANSFERASE	0.006	0.008	0.5
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0219	0.1341	0.1341
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.003	0.003
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0204	0.1219	0.1234
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0173	0.0973	0.0973

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.06 uM	Inhibition of human recombinant MK2	ChEMBL.	23587425
IC50 (binding)	= 1 uM	Inhibition of human LCK	ChEMBL.	23587425
IC50 (binding)	= 1.08 uM	Inhibition of CHK1 (unknown origin)	ChEMBL.	23587425
IC50 (binding)	= 1.1 uM	Inhibition of human CAMK4	ChEMBL.	23587425
IC50 (binding)	= 1.5 uM	Inhibition of human IRAK4	ChEMBL.	23587425
IC50 (binding)	= 12 uM	Inhibition of human TSSK2	ChEMBL.	23587425
IC50 (binding)	= 12 uM	Inhibition of human CSNK1D	ChEMBL.	23587425
IC50 (binding)	= 12 uM	Inhibition of human IGF1R	ChEMBL.	23587425
IC50 (binding)	= 13 uM	Inhibition of human JAK2	ChEMBL.	23587425
IC50 (binding)	> 30 uM	Inhibition of human ERK2	ChEMBL.	23587425
IC50 (binding)	> 30 uM	Inhibition of human MET	ChEMBL.	23587425
IC50 (binding)	> 30 uM	Inhibition of human AKT1	ChEMBL.	23587425
IC50 (binding)	> 30 uM	Inhibition of human IKKB	ChEMBL.	23587425

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2381601

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1761857