Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.2586 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0024 | 0.3648 | 0.3648 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1071 | 0.0551 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4331 | 0.4331 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.1276 | 0.265 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0819 | 0.0211 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0018 | 0.2459 | 0.4987 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.001 | 0.1071 | 0.0551 |
Echinococcus multilocularis | PIK kinase, FAT and Armadillo domain containing protein | 0.0008 | 0.0663 | 0.0323 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0458 | 0.0116 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.2586 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2586 | 0.6709 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.001 | 0.1071 | 0.2014 |
Toxoplasma gondii | FATC domain-containing protein | 0.0024 | 0.3648 | 0.3131 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0018 | 0.2459 | 0.5386 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0018 | 0.2459 | 0.4716 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.2052 | 0.2052 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0018 | 0.2459 | 0.4987 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.8052 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2586 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.2052 | 0.2052 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.001 | 0.1071 | 0.2014 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.2459 | 0.5386 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0021 | 0.3036 | 0.7623 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0839 | 0.0754 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0018 | 0.2459 | 0.5386 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.2586 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.2586 | 0.2602 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.2465 | 0.0485 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.3648 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Echinococcus granulosus | serine protein kinase ATM | 0.0024 | 0.3648 | 0.7625 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0018 | 0.2459 | 0.4716 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.001 | 0.1071 | 0.1071 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.8854 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0839 | 0.0754 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2586 | 0.5523 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.2586 | 0.5879 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.2052 | 0.188 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0018 | 0.2459 | 0.5386 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.2052 | 0.188 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.2052 | 0.188 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.2052 | 0.372 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0018 | 0.2459 | 0.4716 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.2586 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.001 | 0.1071 | 0.2014 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.2052 | 0.372 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.5275 | 0.6241 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Echinococcus granulosus | PIK kinase FAT and Armadillo domain containing protein | 0.0008 | 0.0663 | 0.0323 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.2052 | 0.2052 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.2586 | 0.2602 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0018 | 0.2459 | 0.243 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.2052 | 0.372 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0663 | 0.0752 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0018 | 0.2459 | 0.2459 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.2586 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0531 | 0.0531 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.2586 | 0.5026 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2052 | 0.188 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.2459 | 0.243 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.3648 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.2586 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0018 | 0.2459 | 0.243 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.2459 | 0.243 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.3036 | 0.3211 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.2586 | 0.1729 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Echinococcus granulosus | serine:threonine protein kinase SMG1 | 0.001 | 0.1071 | 0.132 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.2586 | 0.5879 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0018 | 0.2459 | 0.1561 |
Onchocerca volvulus | 0.0028 | 0.4331 | 0.5 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.8052 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1276 | 0.0829 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2586 | 0.5879 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2586 | 0.2586 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.2459 | 0.5386 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0018 | 0.2459 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.001 | 0.1071 | 0.2014 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.4331 | 0.4964 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.4619 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.4331 | 0.4964 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.001 | 0.1071 | 0.2014 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.1276 | 0.265 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4619 | 0.4619 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.8052 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2586 | 0.2586 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.2459 | 0.4987 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0018 | 0.2459 | 0.4716 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2586 | 0.6709 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.3648 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0007 | 0.0458 | 0.0116 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.2052 | 0.372 |
Echinococcus multilocularis | serine:threonine protein kinase SMG1 | 0.001 | 0.1071 | 0.132 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0024 | 0.3648 | 0.404 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.001 | 0.1071 | 0.2014 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2586 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0018 | 0.2459 | 0.4987 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.2586 | 0.5026 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0663 | 0.0663 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0024 | 0.3648 | 0.7625 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0018 | 0.2459 | 0.2459 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.2052 | 0.2052 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.2052 | 0.372 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.2465 | 0.541 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.001 | 0.1071 | 0.2014 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0839 | 0.0238 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.2052 | 0.372 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.3648 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.8052 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.5275 | 0.5275 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.5275 | 0.6241 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.4619 | 1 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0018 | 0.2459 | 0.5386 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0018 | 0.2459 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4619 | 0.4619 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.2459 | 0.6315 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 90 % | Activity at rat recombinant GluN1/GluN2D receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to control | ChEMBL. | 23627311 |
Activity (binding) | = 93 % | Activity at rat recombinant GluN1/GluN2C receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to control | ChEMBL. | 23627311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.