Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aurora kinase A | 0.0664 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0021 | 0.0056 | 0.0009 |
Schistosoma mansoni | cytochrome P450 | 0.0118 | 0.1546 | 0.1504 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0118 | 0.1546 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0128 | 0.1711 | 0.1672 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0118 | 0.1546 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.0056 | 1 | |
Onchocerca volvulus | 0.0021 | 0.0056 | 1 | |
Trypanosoma brucei | aurora B kinase | 0.0664 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0113 | 0.1473 | 0.1433 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0208 | 0.0208 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0664 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0128 | 0.1711 | 0.1665 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0118 | 0.1546 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0128 | 0.1711 | 0.1672 |
Brugia malayi | Protein kinase domain containing protein | 0.0021 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0021 | 0.0056 | 0.0056 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0128 | 0.1711 | 0.1672 |
Echinococcus multilocularis | aurora kinase A | 0.0664 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0664 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0202 | 0.2855 | 0.1549 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0128 | 0.1711 | 0.1665 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0118 | 0.1546 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0118 | 0.1546 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0664 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0664 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0118 | 0.1546 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0037 | 0.0293 | 0.0239 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0109 | 0.1409 | 0.1361 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0031 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0021 | 0.0056 | 0.0056 |
Schistosoma mansoni | tyrosine kinase | 0.0021 | 0.0056 | 0.0006 |
Loa Loa (eye worm) | SRC-1 | 0.0128 | 0.1711 | 0.1711 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0128 | 0.1711 | 0.1665 |
Schistosoma mansoni | tyrosine kinase | 0.0037 | 0.0293 | 0.0245 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0021 | 0.0056 | 0.0002 |
Toxoplasma gondii | aurora kinase | 0.0664 | 1 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0664 | 1 | 1 |
Onchocerca volvulus | 0.0021 | 0.0056 | 1 | |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0113 | 0.1473 | 0.1433 |
Trichomonas vaginalis | AGC family protein kinase | 0.0664 | 1 | 0.5 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0031 | 0.0208 | 0.0153 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0021 | 0.0056 | 0.0056 |
Schistosoma mansoni | tyrosine kinase | 0.0021 | 0.0056 | 0.0006 |
Brugia malayi | Cytochrome P450 family protein | 0.0317 | 0.4633 | 0.4633 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0128 | 0.1711 | 0.1672 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0664 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0664 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0128 | 0.1711 | 0.167 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.1546 | 0.1504 |
Loa Loa (eye worm) | TK protein kinase | 0.0113 | 0.1473 | 0.1473 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0118 | 0.1546 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0118 | 0.1546 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0128 | 0.1711 | 0.167 |
Brugia malayi | Cytochrome P450 family protein | 0.0118 | 0.1546 | 0.1546 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0113 | 0.1473 | 0.1433 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0128 | 0.1711 | 0.1665 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0118 | 0.1546 | 0.1506 |
Onchocerca volvulus | 0.0021 | 0.0056 | 1 | |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0118 | 0.1546 | 0.5 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0109 | 0.1409 | 0.1361 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0128 | 0.1711 | 0.1672 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0128 | 0.1711 | 0.1672 |
Trypanosoma brucei | cytochrome P450, putative | 0.0202 | 0.2855 | 0.1549 |
Schistosoma mansoni | adapter molecule crk | 0.0031 | 0.0208 | 0.0159 |
Brugia malayi | SH2 domain containing protein | 0.0021 | 0.0056 | 0.0056 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0118 | 0.1546 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0113 | 0.1473 | 0.1426 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0202 | 0.2855 | 0.2855 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0021 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1036 | 0.1036 |
Echinococcus multilocularis | 0.0118 | 0.1546 | 0.1498 | |
Mycobacterium leprae | Conserved hypothetical protein | 0.0118 | 0.1546 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0021 | 0.0056 | 0.0056 |
Echinococcus granulosus | c src tyrosine kinase | 0.0037 | 0.0293 | 0.0248 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0109 | 0.1409 | 0.1369 |
Onchocerca volvulus | 0.0021 | 0.0056 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0021 | 0.0056 | 0.0056 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0118 | 0.1546 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0112 | 0.1457 | 0.1457 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0021 | 0.0056 | 0.0056 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0056 | 0.0056 |
Brugia malayi | Cytochrome P450 family protein | 0.0202 | 0.2855 | 0.2855 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0113 | 0.1473 | 0.1426 |
Brugia malayi | protein-tyrosine kinase | 0.0113 | 0.1473 | 0.1473 |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 0.1229 | 0.1182 |
Echinococcus granulosus | tyrosine kinase | 0.0021 | 0.0056 | 0.0009 |
Loa Loa (eye worm) | AUR protein kinase | 0.0664 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0021 | 0.0056 | 0.0056 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0118 | 0.1546 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0118 | 0.1546 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0664 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0021 | 0.0056 | 0.0056 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0128 | 0.1711 | 0.1665 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0128 | 0.1711 | 0.1665 |
Loa Loa (eye worm) | AUR protein kinase | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0021 | 0.0056 | 0.0056 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0664 | 1 | 0.5 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0109 | 0.1409 | 0.1369 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0056 | 0.0056 |
Mycobacterium leprae | putative cytochrome p450 | 0.0118 | 0.1546 | 0.5 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0664 | 1 | 1 |
Giardia lamblia | Aurora kinase | 0.0664 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0109 | 0.1409 | 0.1367 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0113 | 0.1473 | 0.1426 |
Brugia malayi | SRC-1 | 0.0128 | 0.1711 | 0.1711 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0118 | 0.1546 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0021 | 0.0056 | 0.0056 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0021 | 0.0056 | 0.0009 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0118 | 0.1546 | 0.5 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0031 | 0.0208 | 0.0208 |
Leishmania major | protein kinase, putative | 0.0664 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0202 | 0.2855 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0021 | 0.0056 | 0.0056 |
Trichomonas vaginalis | AGC family protein kinase | 0.0664 | 1 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0021 | 0.0056 | 0.0009 |
Echinococcus granulosus | NCK adaptor protein | 0.0031 | 0.0208 | 0.0162 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0128 | 0.1711 | 0.1665 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0118 | 0.1546 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0128 | 0.1711 | 0.1665 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0118 | 0.1546 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0664 | 1 | 1 |
Brugia malayi | Variant SH3 domain containing protein | 0.0031 | 0.0208 | 0.0208 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0037 | 0.0293 | 0.0239 |
Brugia malayi | Variant SH3 domain containing protein | 0.0031 | 0.0208 | 0.0208 |
Onchocerca volvulus | 0.0021 | 0.0056 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0202 | 0.2855 | 0.2855 |
Brugia malayi | serine/threonine kinase 12 | 0.0664 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0664 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0202 | 0.2855 | 0.2855 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0021 | 0.0056 | 0.0056 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0134 | 0.1795 | 0.1757 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0031 | 0.0208 | 0.0208 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0097 | 0.1229 | 0.1188 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0118 | 0.1546 | 0.5 |
Schistosoma mansoni | nck2/grb4 | 0.0031 | 0.0208 | 0.0159 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0031 | 0.0208 | 0.0159 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0031 | 0.0208 | 0.0159 |
Loa Loa (eye worm) | cytochrome P450 | 0.0118 | 0.1546 | 0.1546 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0128 | 0.1711 | 0.1665 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0118 | 0.1546 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0097 | 0.1229 | 0.118 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0021 | 0.0056 | 0.0009 |
Schistosoma mansoni | tyrosine kinase | 0.0037 | 0.0293 | 0.0245 |
Brugia malayi | Protein kinase domain containing protein | 0.0021 | 0.0056 | 0.0056 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0037 | 0.0293 | 0.0293 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0202 | 0.2855 | 0.2855 |
Brugia malayi | cytochrome P450 | 0.0118 | 0.1546 | 0.1546 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0118 | 0.1546 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0112 | 0.1457 | 0.1457 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0664 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0037 | 0.0293 | 0.0239 |
Echinococcus multilocularis | NCK adaptor protein | 0.0031 | 0.0208 | 0.0153 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0664 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0202 | 0.2855 | 0.1549 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0128 | 0.1711 | 0.1672 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0107 | 0.1388 | 0.134 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0031 | 0.0208 | 0.0159 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0037 | 0.0293 | 0.0248 |
Brugia malayi | Protein kinase domain containing protein | 0.0021 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | TK protein kinase | 0.0097 | 0.1229 | 0.1229 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0037 | 0.0293 | 0.0245 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0107 | 0.1388 | 0.1347 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0031 | 0.0208 | 0.0162 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0021 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0317 | 0.4633 | 0.4633 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0202 | 0.2855 | 0.1549 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0664 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.