Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ras homolog family member A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5B | ras homolog family member A | 193 aa | 174 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0101 | 0.0505 | 0.0505 |
Onchocerca volvulus | 0.0101 | 0.0505 | 1 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0101 | 0.0505 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0101 | 0.0505 | 0.0505 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0101 | 0.0505 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0101 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0505 | 0.0505 |
Brugia malayi | Carboxylesterase family protein | 0.0595 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0101 | 0.0505 | 0.0505 |
Echinococcus multilocularis | neuroligin | 0.0101 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0505 | 0.0505 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0101 | 0.0505 | 0.0505 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0101 | 0.0505 | 0.5 |
Onchocerca volvulus | 0.0101 | 0.0505 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0101 | 0.0505 | 0.0505 |
Onchocerca volvulus | 0.0101 | 0.0505 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0101 | 0.0505 | 0.0505 |
Onchocerca volvulus | 0.0101 | 0.0505 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0505 | 0.0505 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0101 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0505 | 0.0505 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0101 | 0.0505 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0101 | 0.0505 | 0.0505 |
Echinococcus granulosus | neuroligin | 0.0101 | 0.0505 | 0.0505 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0101 | 0.0505 | 0.0505 |
Echinococcus granulosus | acetylcholinesterase | 0.0595 | 1 | 1 |
Entamoeba histolytica | Rho family GTPase | 0.0074 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0101 | 0.0505 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0595 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0595 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0595 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0595 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0101 | 0.0505 | 0.0505 |
Echinococcus granulosus | acetylcholinesterase | 0.0595 | 1 | 1 |
Onchocerca volvulus | 0.0101 | 0.0505 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0101 | 0.0505 | 0.0505 |
Brugia malayi | hypothetical protein | 0.0101 | 0.0505 | 0.0505 |
Schistosoma mansoni | acetylcholinesterase | 0.0101 | 0.0505 | 0.0505 |
Echinococcus multilocularis | acetylcholinesterase | 0.0595 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0595 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0101 | 0.0505 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | carboxylesterase | 0.0101 | 0.0505 | 0.0505 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0101 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0595 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0101 | 0.0505 | 0.0505 |
Echinococcus multilocularis | acetylcholinesterase | 0.0595 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0595 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0101 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | carboxylesterase | 0.0101 | 0.0505 | 0.0505 |
Schistosoma mansoni | gliotactin | 0.0101 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0505 | 0.0505 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 uM | Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay | ChEMBL. | 23707258 |
Inhibition (functional) | < 30 % | Antimetastatic activity against human PC3 cells at 10 uM after 24 hrs by scratch wound assay | ChEMBL. | 23707258 |
Inhibition (binding) | = 59 % | Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription at 100 uM by luciferase reporter gene assay | ChEMBL. | 23707258 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.