Detailed information for compound 1763388

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 282.398 | Formula: C15H22O3S
  • H donors: 0 H acceptors: 1 LogP: 2.85 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)/C=C/C1C2[C@@]1(C)[C@@H](C)CCC12OCCS1
  • InChi: 1S/C15H22O3S/c1-10-6-7-15(18-8-9-19-15)13-11(14(10,13)2)4-5-12(16)17-3/h4-5,10-11,13H,6-9H2,1-3H3/b5-4+/t10-,11?,13?,14-,15?/m0/s1
  • InChiKey: KEMPVPODOJBOPZ-RHYRPCKGSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0032 0.0166 0.0472
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0097 0.0097
Giardia lamblia Kinase, CMGC CDK 0.0032 0.0171 0.028
Loa Loa (eye worm) SRC-1 0.0028 0.0142 0.0159
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0109 0.066 0.066
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0025 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0171 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0006 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0138
Schistosoma mansoni rab6-interacting 0.0021 0.0097 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.084 0.5301 1
Echinococcus multilocularis 0.0025 0.0123 0.0123
Loa Loa (eye worm) phosphatidylinositol kinase 0.0025 0.0123 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0138
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0109 0.066 0.3384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0577 0.363 0.6841
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0103 0.0174
Echinococcus granulosus cyclin dependent kinase 5 0.0032 0.0171 0.0171
Echinococcus granulosus tyrosine protein kinase Src64B 0.0028 0.0142 0.0142
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0025 0.0123 0.0463
Entamoeba histolytica cell division protein kinase 2, putative 0.0032 0.0171 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0025 0.0123 0.0123
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0025 0.0123 0.0123
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0308 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0123 0.0123
Onchocerca volvulus Huntingtin homolog 0.0141 0.0861 0.5245
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0025 0.0123 0.0123
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0025 0.0123 0.0213
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.084 0.5301 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0028 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0032 0.0166 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0281 0.175 0.3169
Brugia malayi SRC-1 0.0028 0.0142 0.0268
Brugia malayi MAP kinase sur-1 0.0054 0.0308 0.0581
Schistosoma mansoni tyrosine kinase 0.0006 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Blk 0.0025 0.0125 0.0125
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0123 0.0232
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0123 0.0138
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0025 0.0123 0.0123
Echinococcus granulosus tyrosine protein kinase Lyn 0.0029 0.0147 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0025 0.0123 0.0039
Echinococcus granulosus c src tyrosine kinase 0.0006 0.0005 0.0005
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0123 0.5
Echinococcus multilocularis RUN 0.0021 0.0097 0.0097
Echinococcus multilocularis cyclin dependent kinase 5 0.0032 0.0171 0.0171
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0308 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Loa Loa (eye worm) hypothetical protein 0.0032 0.0169 0.019
Loa Loa (eye worm) phosphatidylinositol 3 0.1408 0.891 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0308 0.0563
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0028 0.0142 0.0142
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0006 0.0005 0.0005
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0109 0.066 0.1073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0123 0.0232
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0103 0.0103
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0169 0.0169
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0123 0.0366
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0103 0.0101
Mycobacterium ulcerans haloalkane dehalogenase 0.0605 0.3808 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.084 0.5301 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0308 0.0563
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0109 0.066 0.066
Schistosoma mansoni ap endonuclease 0.0022 0.0103 0.0103
Trichomonas vaginalis CMGC family protein kinase 0.0032 0.0171 0.0303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Brugia malayi hypothetical protein 0.0021 0.0097 0.0183
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.074 0.4665 0.88
Echinococcus multilocularis dnaJ subfamily B 0.045 0.2824 0.2824
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0035 0.0035
Trypanosoma cruzi cdc2-related kinase 3 0.0032 0.0171 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Echinococcus multilocularis tyrosine protein kinase Srms 0.0025 0.0125 0.0125
Trypanosoma cruzi cdc2-related kinase 3 0.0032 0.0171 0.0131
Leishmania major hypothetical protein, conserved 0.0025 0.0123 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma cruzi cdc2-related kinase 1 0.0032 0.0171 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0308 0.0395
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0097 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0169 0.0169
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0308 0.0563
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1579 1 1
Schistosoma mansoni tyrosine kinase 0.0028 0.0142 0.0142
Entamoeba histolytica hypothetical protein 0.0025 0.0123 0.0039
Loa Loa (eye worm) hypothetical protein 0.0544 0.3421 0.3839
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0281 0.175 0.3169
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0123 0.0123
Echinococcus multilocularis cyclin dependent kinase 1 0.0032 0.0171 0.0171
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0025 0.0123 0.0366
Echinococcus multilocularis c src tyrosine kinase 0.0006 0.0005 0.0005
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.084 0.5301 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0028 0.0142 0.0142
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0109 0.066 0.1073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0025 0.0123 0.0039
Echinococcus granulosus tyrosine protein kinase Fyn 0.0028 0.0142 0.0142
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0025 0.0123 0.0124
Loa Loa (eye worm) hypothetical protein 0.0141 0.0861 0.0967
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0006 0.0005 0.0005
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0025 0.0123 0.0039
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0028 0.0142 0.0142
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0109 0.066 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0123 0.0124
Trichomonas vaginalis CMGC family protein kinase 0.0032 0.0171 0.0303
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0032 0.0171 0.1225
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0123 0.0124
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0815 0.5143 0.9696
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0281 0.175 0.3169
Brugia malayi Pre-SET motif family protein 0.0032 0.0169 0.0319
Echinococcus granulosus tyrosine protein kinase Src42A 0.0024 0.012 0.012
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0109 0.066 1
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0097 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Echinococcus granulosus dnaJ subfamily B 0.045 0.2824 0.2824
Echinococcus multilocularis Zinc finger, PHD finger 0.0109 0.066 0.066
Giardia lamblia Hypothetical protein 0.0025 0.0123 0.0084
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0032 0.0171 0.0171
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0308 0.0308
Trichomonas vaginalis set domain proteins, putative 0.025 0.1554 0.2918
Loa Loa (eye worm) hypothetical protein 0.0141 0.0861 0.0967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Plasmodium falciparum protein kinase 5 0.0032 0.0171 0.1313
Echinococcus multilocularis cyclin dependent kinase 1 0.0032 0.0171 0.0171
Plasmodium vivax hypothetical protein 0.0025 0.0123 0.0463
Brugia malayi Tyrosine-protein kinase abl-1 0.0006 0.0005 0.0009
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0103 0.0103
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0025 0.0123 0.0366
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0025 0.0123 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0022 0.0022
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0025 0.0123 0.0463
Entamoeba histolytica hypothetical protein 0.0025 0.0123 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0109
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0308 0.0843
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0025 0.0123 0.0123
Echinococcus multilocularis tyrosine protein kinase HCK 0.0022 0.0107 0.0107
Leishmania major phosphatidylinositol 3-kinase, putative 0.0025 0.0123 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0196 0.1213 0.4555
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0028 0.0142 0.0142
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0025 0.0123 0.0124
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0308 0.0395
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0025 0.0123 0.0366
Brugia malayi protein-tyrosine kinase 0.0025 0.0125 0.0235
Echinococcus granulosus cyclin dependent kinase 0.0032 0.0171 0.0171
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0032 0.0171 0.1225
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0022 0.0022
Onchocerca volvulus 0.0032 0.0169 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0025 0.0123 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0032 0.0171 0.0303
Brugia malayi cell division control protein 2 homolog 0.0032 0.0171 0.0322
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0138
Schistosoma mansoni polycystin 1-related 0.0021 0.0097 0.0097
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0028 0.0142 0.0142
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0544 0.3421 0.6454
Schistosoma mansoni cpg binding protein 0.0033 0.0177 0.0177
Trypanosoma brucei cdc2-related kinase 1 0.0032 0.0171 0.0415
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0308 0.3686
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0025 0.0123 0.0039
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0405 0.254 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0025 0.0123 0.0366
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0372 0.2331 0.4287
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0166 0.0186
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0028 0.0142 0.0142
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0109 0.066 0.1228
Onchocerca volvulus 0.025 0.1554 1
Echinococcus multilocularis cyclin dependent kinase 0.0032 0.0171 0.0171
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0754 0.0754
Entamoeba histolytica protein kinase rad3, putative 0.0025 0.0123 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0353 0.4485
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0097 0.0097
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0308 0.3686
Onchocerca volvulus 0.0025 0.0123 0.0179
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0577 0.363 0.6841
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0398 0.0398
Trypanosoma brucei cdc2-related kinase 3 0.0032 0.0171 0.0415
Echinococcus granulosus tyrosine protein kinase HCK 0.0022 0.0107 0.0107
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0001 0.0001
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0123 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0123 0.0138
Giardia lamblia GTOR 0.0025 0.0123 0.0084
Echinococcus granulosus tyrosine kinase 0.0025 0.0125 0.0125
Giardia lamblia Phosphatidylinositol 4-kinase 0.0025 0.0123 0.0084
Schistosoma mansoni loxhd1 0.0021 0.0097 0.0097
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0281 0.175 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0109 0.066 0.1228
Echinococcus granulosus RUN 0.0021 0.0097 0.0097
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0308 0.0395
Brugia malayi hypothetical protein 0.0141 0.0861 0.1625
Leishmania major phosphatidylinositol 3-kinase, putative 0.0109 0.066 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0103 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0754 0.0754
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0668 0.4211 0.7904
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0032 0.0171 0.0192
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0022
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0032 0.0171 0.0192
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0025 0.0123 0.0366
Schistosoma mansoni rab6-interacting 0.0021 0.0097 0.0097
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0103 0.0115
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0025 0.0125 0.0125
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0025 0.0123 0.0123
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0025 0.0123 0.0123
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0123 0.0039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0022
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0097 0.0097
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0025 0.0123 0.0123
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0123 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Echinococcus multilocularis tyrosine protein kinase Abl 0.0006 0.0005 0.0005
Leishmania major phosphatidylinositol 4-kinase, putative 0.0025 0.0123 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0109 0.066 0.1228
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0281 0.175 0.175
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0025 0.0123 0.0039
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0308 0.1247
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0028 0.0142 0.0142
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0034 0.0064
Trypanosoma cruzi cdc2-related kinase 1 0.0032 0.0171 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0123 0.0213
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0169 0.0169
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0024 0.012 0.012
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0025 0.0123 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0109 0.066 0.1245
Schistosoma mansoni ap endonuclease 0.0022 0.0103 0.0103
Leishmania major phosphatidylinositol kinase, putative 0.0025 0.0123 0.0366
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0032 0.0171 0.0192
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0025 0.0123 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1579 1 1
Schistosoma mansoni hypothetical protein 0.0025 0.0123 0.0123
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0123 0.0138
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0123 0.0463
Schistosoma mansoni cpg binding protein 0.0032 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0169 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Onchocerca volvulus 0.0025 0.0123 0.0179
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0103 0.0194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0123 0.0232
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0544 0.3421 0.3421
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0025 0.0125 0.0125
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0025 0.0123 0.0123
Loa Loa (eye worm) phosphatidylinositol 3 0.0256 0.1592 0.1787
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0308 0.0308
Echinococcus granulosus tyrosine protein kinase Fyn 0.0028 0.0142 0.0142
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0025 0.0123 0.0124
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0123 0.0124
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0097 0.0097
Schistosoma mansoni fkbp-rapamycin associated protein 0.0025 0.0123 0.0123
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0171 0.0171
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0123 0.0232
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0123 0.0138
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0032 0.0171 0.1225
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.1362 0.1528
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0025 0.0123 0.0123
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0281 0.175 0.3288
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0103 0.0101
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0028 0.0142 0.0142
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0025 0.0123 0.0123
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0109 0.066 0.066
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0103 0.5
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0025 0.0123 0.0123
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0123 0.0232
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0169 0.0169
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0123 0.0232
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0544 0.3421 0.3421
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0028 0.0142 0.0142
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0025 0.0123 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0025 0.0123 0.0039
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0123 0.0039
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0109 0.066 0.066
Entamoeba histolytica hypothetical protein 0.0025 0.0123 0.0039
Trypanosoma brucei protein kinase, putative 0.0054 0.0308 0.1247
Brugia malayi CXXC zinc finger family protein 0.0032 0.0166 0.0313
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0123 0.0232
Loa Loa (eye worm) TK protein kinase 0.0025 0.0125 0.014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0109
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0109 0.066 0.1073
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0281 0.175 0.3288
Schistosoma mansoni tyrosine kinase 0.0028 0.0142 0.0142
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0109 0.066 0.066
Loa Loa (eye worm) TK protein kinase 0.0022 0.0107 0.012
Schistosoma mansoni hypothetical protein 0.045 0.2824 0.2824
Schistosoma mansoni lipoxygenase 0.0087 0.0517 0.0517
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.084 0.5301 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0025 0.0123 0.0039
Plasmodium vivax protein kinase Crk2 0.0032 0.0171 0.1313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0035 0.0039
Mycobacterium tuberculosis Conserved hypothetical protein 0.0025 0.0123 0.0055
Onchocerca volvulus Huntingtin homolog 0.0141 0.0861 0.5245
Toxoplasma gondii target of rapamycin (TOR), putative 0.0025 0.0123 0.0366
Echinococcus granulosus tyrosine protein kinase Fyn 0.0028 0.0142 0.0142
Echinococcus multilocularis cpg binding protein 0.0033 0.0177 0.0177
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0025 0.0123 0.0123
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0109 0.066 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0025 0.0123 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Schistosoma mansoni cpg binding protein 0.0033 0.0177 0.0177
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0025 0.0123 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Echinococcus granulosus cpg binding protein 0.0033 0.0177 0.0177
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0025 0.0123 0.0039
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0109 0.066 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.0021 0.0097 0.0097
Leishmania major hypothetical protein, unknown function 0.0025 0.0123 0.0366
Plasmodium vivax SET domain protein, putative 0.0032 0.0169 0.1282
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0025 0.0123 0.0123
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0308 0.0395
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0109 0.066 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0025 0.0123 0.0039
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0308 0.0308
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0296 0.1845 0.207
Entamoeba histolytica hypothetical protein 0.0668 0.4211 0.7904
Brugia malayi Doublecortin family protein 0.0021 0.0097 0.0183
Schistosoma mansoni lipoxygenase 0.0124 0.0754 0.0754
Entamoeba histolytica hypothetical protein 0.0025 0.0123 0.0039
Schistosoma mansoni tyrosine kinase 0.0006 0.0005 0.0005
Giardia lamblia Kinase, CMGC CDK 0.0032 0.0171 0.028
Brugia malayi Protein kinase domain containing protein 0.0032 0.0171 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0025 0.0123 0.0124
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0025 0.0123 0.0366
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0025 0.0123 0.0123
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0025 0.0123 0.0123
Leishmania major phosphatidylinositol kinase related protein, putative 0.0025 0.0123 0.0366
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0123 0.0138
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0103 0.0174
Echinococcus granulosus tyrosine protein kinase Src42A 0.0028 0.0142 0.0142
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.084 0.5301 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0025 0.0123 0.0039
Entamoeba histolytica protein kinase, putative 0.0022 0.0107 0.0009
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0169 0.1193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma cruzi target of rapamycin kinase 3 0.0025 0.0123 0.0039
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0025 0.0123 0.0213
Entamoeba histolytica cell division protein kinase 2, putative 0.0032 0.0171 0.0131
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0256 0.1592 0.2865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0308 0.0563
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0169 0.0169
Brugia malayi Pre-SET motif family protein 0.022 0.1362 0.2569
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0025 0.0123 0.0463
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0605 0.3808 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0281 0.175 0.3288
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0025 0.0123 0.0123
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0028 0.0142 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0308 0.0308
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0022 0.0022
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0123 0.0138
Brugia malayi hypothetical protein 0.0021 0.0097 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0109 0.066 0.1073
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0025 0.0123 0.0039
Echinococcus granulosus cyclin dependent kinase 1 0.0032 0.0171 0.0171
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0109 0.066 0.0741
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0281 0.175 0.3301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0123 0.0213
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.084 0.5301 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0308 0.3686
Echinococcus multilocularis tyrosine protein kinase Blk 0.0025 0.0125 0.0125

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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