Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0274 | 0.1362 | 1 | |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0078 | 0.0245 | 0.0245 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1792 | 1 | 1 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0078 | 0.0245 | 0.0245 |
Trypanosoma brucei | protein kinase, putative | 0.1792 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0078 | 0.0245 | 0.0245 |
Trichomonas vaginalis | set domain proteins, putative | 0.0274 | 0.1362 | 0.1145 |
Schistosoma mansoni | unc-13 (munc13) | 0.0078 | 0.0245 | 0.0245 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1792 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0241 | 0.1173 | 0.1173 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0078 | 0.0245 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0136 | 0.058 | 0.058 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1792 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1792 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0078 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0078 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0245 | 0.0245 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0078 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1792 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0638 | 0.3437 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1792 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0136 | 0.058 | 0.058 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1792 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Brugia malayi | Pre-SET motif family protein | 0.0241 | 0.1173 | 0.1173 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0638 | 0.3437 | 0.3437 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1792 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1792 | 1 | 1 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0078 | 0.0245 | 0.0245 |
Brugia malayi | Isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0078 | 0.0245 | 0.0245 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1792 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0078 | 0.0245 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1792 | 1 | 1 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0078 | 0.0245 | 0.0245 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1792 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1792 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0078 | 0.0245 | 0.0245 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0078 | 0.0245 | 0.0245 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1792 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0078 | 0.0245 | 0.0245 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0078 | 0.0245 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0638 | 0.3437 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0638 | 0.3437 | 0.5 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0078 | 0.0245 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0095 | 0.0346 | 0.0346 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0638 | 0.3437 | 0.3272 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1792 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0136 | 0.058 | 0.058 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.035 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.