Detailed information for compound 1763406

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 238.28 | Formula: C13H18O4
  • H donors: 1 H acceptors: 3 LogP: 0.48 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@H]1CCC[C@@H]2[C@H]1C(=O)C(=C2CO)C
  • InChi: 1S/C13H18O4/c1-7-10(6-14)8-4-3-5-9(13(16)17-2)11(8)12(7)15/h8-9,11,14H,3-6H2,1-2H3/t8-,9-,11+/m0/s1
  • InChiKey: PRBDOAIFHXDNOT-ATZCPNFKSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni suppressor of cytokine signaling 0.0084 0.234 0.2298
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.234 0.234
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.3327 1
Brugia malayi SH2 domain containing protein 0.0084 0.234 0.221
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0113 0.3327 0.5274
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0034 0.0658 0.0608
Loa Loa (eye worm) TK/FER protein kinase 0.0197 0.6159 0.6159
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Toxoplasma gondii STE kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus granulosus solute carrier family 5 0.0034 0.0665 0.0614
Schistosoma mansoni suppressor of cytokine signaling 0.0084 0.234 0.2298
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Brugia malayi PHD-finger family protein 0.0024 0.0305 0.0141
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0084 0.234 0.2298
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Brugia malayi ephrin receptor 1 precursor 0.0113 0.3327 0.3214
Echinococcus granulosus SH2 domain containing adapter protein F 0.0084 0.234 0.2298
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK/ALK protein kinase 0.0113 0.3327 0.3327
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0073 0.0073
Echinococcus granulosus expressed conserved protein 0.0084 0.234 0.2298
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0057 0.1419 0.1373
Brugia malayi Tyrosine-protein kinase PR2 0.0113 0.3327 0.3214
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0084 0.234 0.3627
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0084 0.234 0.2298
Loa Loa (eye worm) TK/FAK protein kinase 0.0113 0.3327 0.3327
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0113 0.3327 0.3291
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0113 0.3327 0.5274
Entamoeba histolytica serine/threonine kinase, putative 0.0113 0.3327 0.5274
Brugia malayi SH2 domain containing protein 0.0084 0.234 0.221
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0113 0.3327 0.3327
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0084 0.234 0.2298
Brugia malayi Tensin 0.0084 0.234 0.221
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0113 0.3327 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0113 0.3327 0.3291
Schistosoma mansoni tyrosine kinase 0.0197 0.6159 0.6138
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0028 0.0439 0.0454
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Loa Loa (eye worm) hypothetical protein 0.002 0.0167 0.0167
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Onchocerca volvulus 0.0113 0.3327 0.5274
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Loa Loa (eye worm) TK protein kinase 0.0113 0.3327 0.3327
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Trypanosoma brucei Pseudokinase, putative 0.0113 0.3327 1
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0084 0.234 0.2298
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0113 0.3327 0.3291
Onchocerca volvulus 0.0113 0.3327 0.5274
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Schistosoma mansoni protein tyrosine kinase 0.0113 0.3327 0.3291
Echinococcus multilocularis integrin linked protein kinase 0.0113 0.3327 0.3291
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0034 0.0665 0.0784
Echinococcus multilocularis NCK adaptor protein 0.0084 0.234 0.2298
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus granulosus tyrosine protein kinase csk 0.0113 0.3327 0.3291
Onchocerca volvulus Tyrosine kinase homolog 0.0113 0.3327 0.5274
Brugia malayi RhoGAP domain containing protein 0.0084 0.234 0.221
Loa Loa (eye worm) TK/ACK protein kinase 0.0113 0.3327 0.3327
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK/FER protein kinase 0.0197 0.6159 0.6159
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0025 0.0341 1
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0113 0.3327 0.3214
Entamoeba histolytica ankyrin repeat protein 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis tyrosine kinase 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus granulosus tyrosine protein kinase shark 0.0197 0.6159 0.6138
Echinococcus multilocularis growth factor receptor bound protein 2 0.0084 0.234 0.2298
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0113 0.3327 0.3327
Schistosoma mansoni bromodomain containing protein 0.006 0.1534 0.1488
Onchocerca volvulus 0.0197 0.6159 1
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0034 0.0665 0.0614
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Trichomonas vaginalis protein kinase atn1, putative 0.0113 0.3327 1
Echinococcus granulosus SH2 motif 0.0084 0.234 0.2298
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0113 0.3327 0.3291
Echinococcus granulosus tyrosine kinase 0.0197 0.6159 0.6138
Echinococcus granulosus tyrosine protein kinase Src42A 0.0197 0.6159 0.6138
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0084 0.234 0.234
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Brugia malayi protein-tyrosine kinase 0.0197 0.6159 0.6094
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Brugia malayi Receptor family ligand binding region containing protein 0.0113 0.3327 0.3214
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK/EPH protein kinase 0.0113 0.3327 0.3327
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0084 0.234 0.2298
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0113 0.3327 0.3291
Brugia malayi Inositol-1 0.0028 0.0439 0.0277
Entamoeba histolytica ankyrin repeat protein 0.0113 0.3327 0.5274
Schistosoma mansoni SH2A 0.0084 0.234 0.2298
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) RGC/RGC protein kinase 0.0113 0.3327 0.3327
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Echinococcus granulosus tyrosine protein kinase Src64B 0.0197 0.6159 0.6138
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Echinococcus multilocularis epidermal growth factor receptor 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK/FER protein kinase 0.0197 0.6159 0.6159
Brugia malayi Protein kinase domain containing protein 0.0197 0.6159 0.6094
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0113 0.3327 0.3291
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Brugia malayi SH2 domain containing protein 0.0084 0.234 0.221
Echinococcus granulosus epidermal growth factor receptor 0.0113 0.3327 0.3291
Echinococcus granulosus inositol monophosphatase 1 0.0028 0.0439 0.0387
Onchocerca volvulus 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0197 0.6159 0.6138
Echinococcus multilocularis FL cytokine receptor 0.0113 0.3327 0.3291
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Echinococcus granulosus growth factor receptor bound protein 2 0.0084 0.234 0.2298
Echinococcus multilocularis inositol monophosphatase 1 0.0028 0.0439 0.0387
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0197 0.6159 0.6138
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK/FER protein kinase 0.0197 0.6159 0.6159
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Loa Loa (eye worm) TK/Met protein kinase 0.0113 0.3327 0.3327
Schistosoma mansoni inositol monophosphatase 0.0028 0.0439 0.0387
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Echinococcus multilocularis tyrosine protein kinase pr2 0.0113 0.3327 0.3291
Echinococcus granulosus SH2 domain containing protein 7 0.0084 0.234 0.2298
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0113 0.3327 0.3327
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Echinococcus multilocularis 0.0084 0.234 0.2298
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Schistosoma mansoni tensin 0.0084 0.234 0.2298
Echinococcus multilocularis tyrosine protein kinase csk 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis heat shock protein 70 0.0113 0.3327 0.3291
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Schistosoma mansoni signal transduction protein lnk-related 0.0084 0.234 0.2298
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Onchocerca volvulus 0.0113 0.3327 0.5274
Brugia malayi Bromodomain containing protein 0.0071 0.1909 0.1772
Brugia malayi SH2 domain containing protein 0.0197 0.6159 0.6094
Brugia malayi Variant SH3 domain containing protein 0.0084 0.234 0.221
Plasmodium falciparum protein kinase, putative 0.0113 0.3327 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0084 0.234 0.2298
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0167 0.3798
Onchocerca volvulus 0.0084 0.234 0.3627
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0084 0.234 0.2298
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0034 0.0665 0.0614
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.3327 0.3327
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Brugia malayi integrin-linked kinase 0.0113 0.3327 0.3214
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0113 0.3327 0.3291
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0113 0.3327 1
Schistosoma mansoni serine/threonine RGC 0.0113 0.3327 0.3291
Brugia malayi Immunoglobulin I-set domain containing protein 0.0113 0.3327 0.3214
Loa Loa (eye worm) TK/INSR protein kinase 0.0113 0.3327 0.3327
Trichomonas vaginalis protein tyrosine kinase, putative 0.0113 0.3327 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0021 0.023 0.0177
Schistosoma mansoni vav2 0.0084 0.234 0.2298
Echinococcus granulosus tyrosine kinase 0.0197 0.6159 0.6138
Echinococcus granulosus integrin linked protein kinase 0.0113 0.3327 0.3291
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0113 0.3327 0.3214
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0113 0.3327 1
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0113 0.3327 0.3291
Schistosoma mansoni inositol transporter 0.0034 0.0665 0.0614
Echinococcus granulosus retinal guanylyl cyclase 2 0.0113 0.3327 0.3291
Schistosoma mansoni tyrosine protein kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK/ABL protein kinase 0.0197 0.6159 0.6159
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0197 0.6159 0.6138
Schistosoma mansoni tensin-related 0.0084 0.234 0.2298
Echinococcus granulosus tyrosine protein kinase HCK 0.0113 0.3327 0.3291
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Echinococcus multilocularis tyrosine protein kinase Blk 0.0197 0.6159 0.6138
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0084 0.234 0.2298
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0113 0.3327 0.3291
Echinococcus multilocularis high affinity choline transporter 1 0.0311 1 1
Schistosoma mansoni tyrosine kinase 0.0197 0.6159 0.6138
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.3327 0.3327
Loa Loa (eye worm) RGC/RGC protein kinase 0.0113 0.3327 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) TK/FER protein kinase 0.0197 0.6159 0.6159
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) TK/FER protein kinase 0.0197 0.6159 0.6159
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0113 0.3327 0.3327
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0113 0.3327 0.3214
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0113 0.3327 0.3327
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Echinococcus granulosus receptor type guanylyl cyclase 0.0113 0.3327 0.3291
Echinococcus granulosus protein kinase 0.0113 0.3327 0.3291
Brugia malayi hypothetical protein 0.0084 0.234 0.221
Echinococcus multilocularis SH2 domain containing protein 7 0.0084 0.234 0.2298
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Echinococcus granulosus sodium:myo inositol cotransporter 0.0034 0.0665 0.0614
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0084 0.234 0.2298
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Brugia malayi Bromodomain containing protein 0.0036 0.0734 0.0577
Loa Loa (eye worm) inositol-1 0.0028 0.0439 0.0439
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Onchocerca volvulus 0.0197 0.6159 1
Brugia malayi hypothetical protein 0.0113 0.3327 0.3214
Echinococcus granulosus raf serine:threonine protein kinase 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Schistosoma mansoni inositol transporter 0.0034 0.0665 0.0614
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.002 0.0167 0.4885
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.3327 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Echinococcus granulosus tyrosine protein kinase Src42A 0.0084 0.234 0.2298
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0034 0.0658 0.0608
Loa Loa (eye worm) hypothetical protein 0.0197 0.6159 0.6159
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0197 0.6159 0.6138
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0084 0.234 0.234
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0028 0.0439 1
Giardia lamblia Protein 21.1 0.0113 0.3327 0.5
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Schistosoma mansoni hypothetical protein 0.0084 0.234 0.2298
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0439 0.0861
Entamoeba histolytica tyrosin kinase, putative 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Echinococcus multilocularis SH2 motif 0.0084 0.234 0.2298
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0113 0.3327 1
Brugia malayi Furin-like cysteine rich region family protein 0.0113 0.3327 0.3214
Brugia malayi SH2 domain containing protein 0.0197 0.6159 0.6094
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0057 0.1419 0.1373
Brugia malayi C-terminal src kinase protein 1 0.0113 0.3327 0.3214
Loa Loa (eye worm) TK/DDR protein kinase 0.0113 0.3327 0.3327
Onchocerca volvulus 0.0084 0.234 0.3627
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Loa Loa (eye worm) hypothetical protein 0.0041 0.0882 0.0882
Echinococcus granulosus sodium:glucose cotransporter 0.0034 0.0665 0.0614
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Onchocerca volvulus 0.0113 0.3327 0.5274
Onchocerca volvulus 0.0197 0.6159 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Leishmania major protein kinase, putative 0.0113 0.3327 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0113 0.3327 0.3291
Brugia malayi Tyrosine-protein kinase abl-1 0.0197 0.6159 0.6094
Leishmania major hypothetical protein, conserved 0.0113 0.3327 1
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Entamoeba histolytica tyrosin kinase, putative 0.0113 0.3327 0.5274
Brugia malayi SH2 domain containing protein 0.0084 0.234 0.221
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Loa Loa (eye worm) SH2 domain-containing protein 0.0084 0.234 0.234
Brugia malayi Immunoglobulin I-set domain containing protein 0.0113 0.3327 0.3214
Onchocerca volvulus 0.0034 0.0665 0.0832
Plasmodium vivax tyrosine kinase-like protein, putative 0.0113 0.3327 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.234 0.234
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0113 0.3327 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) MH2 domain-containing protein 0.0098 0.2825 0.2825
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0084 0.234 0.2298
Loa Loa (eye worm) TK protein kinase 0.0113 0.3327 0.3327
Echinococcus multilocularis transfer RNA-Thr 0.0113 0.3327 0.3291
Echinococcus multilocularis activin receptor type 0.0113 0.3327 0.3291
Loa Loa (eye worm) hypothetical protein 0.0039 0.0812 0.0812
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0113 0.3327 0.5274
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Giardia lamblia Kinase, NEK 0.0113 0.3327 0.5
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Echinococcus multilocularis tyrosine protein kinase Srms 0.0197 0.6159 0.6138
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Entamoeba histolytica serine/threonine kinase, putative 0.0113 0.3327 0.5274
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Brugia malayi hypothetical protein 0.0197 0.6159 0.6094
Entamoeba histolytica receptor protein kinase, putative 0.0113 0.3327 0.5274
Plasmodium falciparum protein kinase, putative 0.0113 0.3327 1
Onchocerca volvulus 0.0113 0.3327 0.5274
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.002 0.0167 0.3798
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0084 0.234 0.234
Trypanosoma brucei Flagellum attachment zone protein 20 0.0113 0.3327 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0113 0.3327 0.3291
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Plasmodium falciparum tyrosine kinase-like protein 0.0113 0.3327 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0113 0.3327 1
Brugia malayi MH2 domain containing protein 0.0098 0.2825 0.2704
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0113 0.3327 1
Leishmania major protein kinase, putative 0.0113 0.3327 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.002 0.0167 0.3798
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0197 0.6159 0.6138
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Echinococcus granulosus activated cdc42 kinase 1 0.0113 0.3327 0.3291
Onchocerca volvulus 0.0113 0.3327 0.5274
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Echinococcus granulosus SH2 motif 0.0084 0.234 0.2298
Echinococcus granulosus SHC transforming protein 3 0.0084 0.234 0.2298
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0113 0.3327 0.3327
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0084 0.234 0.2298
Trypanosoma cruzi protein kinase, putative 0.0113 0.3327 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0113 0.3327 0.3291
Echinococcus multilocularis tyrosine protein kinase HCK 0.0113 0.3327 0.3291
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0113 0.3327 0.3291
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0167 0.4885
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.234 0.2298
Echinococcus multilocularis tyrosine protein kinase csk 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0113 0.3327 0.3291
Entamoeba histolytica tyrosin kinase, putative 0.0113 0.3327 0.5274
Trypanosoma cruzi protein kinase, putative 0.0113 0.3327 1
Echinococcus granulosus tensin 0.0084 0.234 0.2298
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0015 0 0.5
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0113 0.3327 0.3291
Onchocerca volvulus 0.0084 0.234 0.3627
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0197 0.6159 0.6138
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0084 0.234 0.2298
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0113 0.3327 0.3327
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Entamoeba histolytica serine/threonine kinase, putative 0.0113 0.3327 0.5274
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Plasmodium vivax tyrosine kinase-like protein, putative 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0113 0.3327 0.3291
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Brugia malayi Raf kinase 0.0113 0.3327 0.3214
Echinococcus granulosus fibroblast growth factor receptor 4 0.0113 0.3327 0.3291
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) hypothetical protein 0.0067 0.1772 0.1772
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Loa Loa (eye worm) TK protein kinase 0.0113 0.3327 0.3327
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Schistosoma mansoni tyrosine kinase 0.0197 0.6159 0.6138
Brugia malayi Protein kinase domain containing protein 0.0197 0.6159 0.6094
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0113 0.3327 0.3291
Entamoeba histolytica serine/threonine kinase, putative 0.0113 0.3327 0.5274
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0084 0.234 0.3627
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0084 0.234 0.2298
Echinococcus granulosus tyrosine protein kinase ABL1 0.0197 0.6159 0.6138
Echinococcus granulosus epidermal growth factor receptor 0.0113 0.3327 0.3291
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0167 0.3798
Brugia malayi tRNA modification GTPase TrmE family protein 0.0084 0.234 0.221
Echinococcus granulosus sodium:glucose cotransporter 2 0.0034 0.0665 0.0614
Trypanosoma brucei protein kinase, putative 0.0113 0.3327 1
Brugia malayi hypothetical protein 0.0113 0.3327 0.3214
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0113 0.3327 0.3291
Loa Loa (eye worm) hypothetical protein 0.0034 0.0665 0.0665
Echinococcus granulosus tumor protein p63 0.0279 0.8898 0.8892
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.3327 0.3291
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0197 0.6159 0.6138
Echinococcus multilocularis epidermal growth factor receptor 0.0113 0.3327 0.3291
Brugia malayi Sex muscle abnormal protein 5 0.0084 0.234 0.221
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0113 0.3327 0.3291
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) SH2 domain-containing protein 0.0084 0.234 0.234
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.3327 0.3327
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0113 0.3327 0.3291
Echinococcus granulosus hypothetical protein 0.0084 0.234 0.2298
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0084 0.234 0.2298
Echinococcus multilocularis tyrosine protein kinase shark 0.0197 0.6159 0.6138
Giardia lamblia Kinase, NEK 0.0113 0.3327 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0167 0.0167
Schistosoma mansoni sodium/solute symporter 0.0034 0.0665 0.0614
Trichomonas vaginalis TK family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) TK protein kinase 0.0113 0.3327 0.3327
Echinococcus granulosus suppressor of cytokine signaling 6 0.0084 0.234 0.2298
Loa Loa (eye worm) TK protein kinase 0.0113 0.3327 0.3327
Schistosoma mansoni inositol monophosphatase 0.0028 0.0439 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.3327 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0113 0.3327 0.3291
Loa Loa (eye worm) protein kinase domain-containing protein 0.0113 0.3327 0.3327
Echinococcus granulosus N chimaerin 0.0084 0.234 0.2298
Echinococcus multilocularis activated cdc42 kinase 1 0.0113 0.3327 0.3291
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0054
Brugia malayi cytokine inducible SH2-containing protein 5 0.0084 0.234 0.221
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0873 0.0873
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0113 0.3327 0.3291
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.3327 0.3327
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0197 0.6159 0.6138
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0197 0.6159 0.6138
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0197 0.6159 0.6138
Echinococcus multilocularis tyrosine kinase 0.0197 0.6159 0.6138
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0113 0.3327 0.3327
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Echinococcus multilocularis c src tyrosine kinase 0.0197 0.6159 0.6138
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) SRC-1 0.0197 0.6159 0.6159
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0113 0.3327 0.3214
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus granulosus insulin receptor 0.0113 0.3327 0.3291
Entamoeba histolytica tyrosin kinase, putative 0.0113 0.3327 0.5274
Onchocerca volvulus 0.0113 0.3327 0.5274
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.3327 0.3327
Entamoeba histolytica serine/threonine kinase, putative 0.0113 0.3327 0.5274
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0021 0.023 0.0177
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0113 0.3327 0.3327
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Schistosoma mansoni adapter molecule crk 0.0084 0.234 0.2298
Entamoeba histolytica protein kinase, putative 0.0084 0.234 0.3627
Echinococcus granulosus tyrosine protein kinase csk 0.0113 0.3327 0.3291
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0028 0.0439 0.5
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Echinococcus multilocularis tensin 0.0084 0.234 0.2298
Echinococcus multilocularis protein kinase 0.0113 0.3327 0.3291
Echinococcus granulosus tyrosine protein kinase Blk 0.0197 0.6159 0.6138
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0084 0.234 0.2298
Schistosoma mansoni tyrosine kinase 0.0197 0.6159 0.6138
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Echinococcus granulosus tyrosine protein kinase csk 0.0113 0.3327 0.3291
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Echinococcus multilocularis SH2 motif 0.0084 0.234 0.2298
Entamoeba histolytica serine/threonine kinase, putative 0.0113 0.3327 0.5274
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0113 0.3327 0.3291
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0021 0.023 0.0177
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0197 0.6159 0.6138
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0197 0.6159 0.6138
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Entamoeba histolytica SH2 domain containing protein 0.0084 0.234 0.3627
Loa Loa (eye worm) TK/RYK protein kinase 0.0113 0.3327 0.3327
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0113 0.3327 0.3291
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Echinococcus granulosus activin receptor type 0.0113 0.3327 0.3291
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Brugia malayi SRC-1 0.0197 0.6159 0.6094
Brugia malayi Sodium:solute symporter family protein 0.0034 0.0665 0.0507
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Mycobacterium ulcerans hypothetical protein 0.002 0.0167 0.3798
Brugia malayi Guanylyl cyclase protein 23 0.0113 0.3327 0.3214
Echinococcus granulosus natriuretic peptide receptor 1 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.3327 0.3327
Echinococcus multilocularis SHC transforming protein 3 0.0084 0.234 0.2298
Schistosoma mansoni ephrin receptor 0.0113 0.3327 0.3291
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0197 0.6159 0.6138
Echinococcus granulosus activated cdc42 kinase 1 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0197 0.6159 0.6138
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis SH2 motif 0.0084 0.234 0.2298
Onchocerca volvulus 0.0041 0.0882 0.1194
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0197 0.6159 0.6138
Giardia lamblia Kinase 0.0113 0.3327 0.5
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Echinococcus granulosus tyrosine protein kinase 0.0113 0.3327 0.3291
Brugia malayi Protein kinase domain containing protein 0.0197 0.6159 0.6094
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Trichomonas vaginalis STE family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0197 0.6159 0.6138
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0113 0.3327 0.3327
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0113 0.3327 0.3214
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0084 0.234 0.2298
Echinococcus granulosus NCK adaptor protein 0.0084 0.234 0.2298
Loa Loa (eye worm) TK/FER protein kinase 0.0197 0.6159 0.6159
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0113 0.3327 0.3291
Loa Loa (eye worm) hypothetical protein 0.0084 0.234 0.234
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Loa Loa (eye worm) hypothetical protein 0.002 0.0167 0.0167
Brugia malayi bone morphogenetic protein type 1 receptor 0.0113 0.3327 0.3214
Schistosoma mansoni tensin 0.0084 0.234 0.2298
Echinococcus multilocularis tumor protein p63 0.0279 0.8898 0.8892
Echinococcus multilocularis tensin 0.0084 0.234 0.2298
Plasmodium falciparum tyrosine kinase-like protein 0.0113 0.3327 1
Echinococcus granulosus high affinity choline transporter 1 0.0311 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0025 0.0341 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0197 0.6159 0.6138
Toxoplasma gondii protein kinase domain-containing protein 0.0113 0.3327 1
Schistosoma mansoni nck2/grb4 0.0084 0.234 0.2298
Echinococcus granulosus protein tyrosine kinase 0.0113 0.3327 0.3291
Schistosoma mansoni hypothetical protein 0.0084 0.234 0.2298
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0113 0.3327 0.3214
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0034 0.0665 0.0614
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0084 0.234 0.2298
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Schistosoma mansoni tyrosine kinase 0.0197 0.6159 0.6138
Loa Loa (eye worm) TK protein kinase 0.0197 0.6159 0.6159
Echinococcus multilocularis N chimaerin 0.0084 0.234 0.2298
Loa Loa (eye worm) TK protein kinase 0.0113 0.3327 0.3327
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Echinococcus granulosus signal transduction protein lnk realted 0.0084 0.234 0.2298
Echinococcus multilocularis tyrosine protein kinase csk 0.0113 0.3327 0.3291
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.3327 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.002 0.0167 0.3798
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Loa Loa (eye worm) SH2 domain-containing protein 0.0084 0.234 0.234
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0113 0.3327 0.3291
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0084 0.234 0.2298
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK protein kinase 0.0113 0.3327 0.3327
Echinococcus granulosus tyrosine protein kinase pr2 0.0113 0.3327 0.3291
Echinococcus granulosus kinase suppressor of Ras 1 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Brugia malayi SH2 domain containing protein 0.0084 0.234 0.221
Echinococcus multilocularis protein kinase 0.0113 0.3327 0.3291
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.234 0.2298
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0113 0.3327 0.3291
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0084 0.234 0.2298
Brugia malayi SH2 domain containing protein 0.0084 0.234 0.221
Schistosoma mansoni zinc finger protein 0.0019 0.0135 0.0081
Plasmodium falciparum protein kinase, putative 0.0113 0.3327 1
Echinococcus granulosus zinc finger protein 0.0019 0.0135 0.0081
Brugia malayi Variant SH3 domain containing protein 0.0084 0.234 0.221
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Schistosoma mansoni tensin 0.0084 0.234 0.2298
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0167 0.3798
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0084 0.234 0.221
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) TK/FER protein kinase 0.0197 0.6159 0.6159
Echinococcus multilocularis ephrin type A receptor 4 A 0.0113 0.3327 0.3291
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Echinococcus granulosus tyrosine protein kinase Fyn 0.0197 0.6159 0.6138
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0113 0.3327 0.3291
Schistosoma mansoni hypothetical protein 0.002 0.0168 0.0115
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0113 0.3327 0.3291
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0113 0.3327 0.5274
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0197 0.6159 1
Entamoeba histolytica cysteine surface protein, putative 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0113 0.3327 0.3327
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Loa Loa (eye worm) hypothetical protein 0.0113 0.3327 0.3327
Loa Loa (eye worm) TK/FER protein kinase 0.0197 0.6159 0.6159
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Schistosoma mansoni cellular tumor antigen P53 0.0041 0.0882 0.0833
Trichomonas vaginalis AGC family protein kinase 0.0113 0.3327 1
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Toxoplasma gondii protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0084 0.234 0.234
Brugia malayi STAT protein, DNA binding domain containing protein 0.0084 0.234 0.221
Schistosoma mansoni ephrin receptor 0.0113 0.3327 0.3291
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0197 0.6159 0.6138
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0084 0.234 0.3627
Loa Loa (eye worm) hypothetical protein 0.0311 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0197 0.6159 0.6138
Schistosoma mansoni GTPase activating protein 0.0084 0.234 0.2298
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0113 0.3327 0.3291
Echinococcus granulosus tyrosine protein kinase Srms 0.0197 0.6159 0.6138
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Schistosoma mansoni tyrosine kinase 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0113 0.3327 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis solute carrier family 5 0.0034 0.0665 0.0614
Onchocerca volvulus 0.0084 0.234 0.3627
Schistosoma mansoni tyrosine kinase 0.0197 0.6159 0.6138
Echinococcus multilocularis insulin receptor 0.0113 0.3327 0.3291
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0197 0.6159 0.6138
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0084 0.234 0.2298
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Echinococcus granulosus tyrosine kinase 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Schistosoma mansoni tensin-related 0.0084 0.234 0.2298
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Echinococcus granulosus c src tyrosine kinase 0.0197 0.6159 0.6138
Brugia malayi Protein kinase domain containing protein 0.0197 0.6159 0.6094
Entamoeba histolytica receptor protein kinase, putative 0.0113 0.3327 0.5274
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.3327 0.3327
Onchocerca volvulus 0.0197 0.6159 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0113 0.3327 0.3291
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0034 0.0665 0.0614
Onchocerca volvulus 0.0113 0.3327 0.5274
Echinococcus granulosus tyrosine protein kinase Fyn 0.0197 0.6159 0.6138
Onchocerca volvulus 0.0197 0.6159 1
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.3327 1
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.3327 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0113 0.3327 1
Entamoeba histolytica hypothetical protein, conserved 0.0113 0.3327 0.5274
Echinococcus multilocularis tyrosine protein kinase 0.0113 0.3327 0.3291
Schistosoma mansoni protein kinase 0.0113 0.3327 0.3291
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0113 0.3327 0.3291
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0084 0.234 0.2298
Schistosoma mansoni shc transforming protein 0.0084 0.234 0.2298
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0197 0.6159 0.6138
Loa Loa (eye worm) RGC/RGC protein kinase 0.0113 0.3327 0.3327
Entamoeba histolytica hypothetical protein 0.0113 0.3327 0.5274
Brugia malayi Protein kinase domain containing protein 0.0197 0.6159 0.6094
Loa Loa (eye worm) TK protein kinase 0.0113 0.3327 0.3327
Echinococcus multilocularis tyrosine protein kinase csk 0.0113 0.3327 0.3291
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0168 0.0168
Loa Loa (eye worm) transcription factor SMAD2 0.0098 0.2825 0.2825
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0167 0.3798
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.3327 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0113 0.3327 0.3291
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0113 0.3327 0.3291
Loa Loa (eye worm) hypothetical protein 0.0036 0.0736 0.0736
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Echinococcus multilocularis protein tyrosine kinase 0.0113 0.3327 0.3291
Brugia malayi Variant SH3 domain containing protein 0.0084 0.234 0.221
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.3327 0.5274
Schistosoma mansoni hypothetical protein 0.0113 0.3327 0.3291
Loa Loa (eye worm) TK protein kinase 0.0113 0.3327 0.3327
Echinococcus multilocularis zinc finger protein 0.0019 0.0135 0.0081
Echinococcus granulosus ephrin type A receptor 4 A 0.0113 0.3327 0.3291
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0113 0.3327 0.3327
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0113 0.3327 0.3291
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Trichomonas vaginalis TKL family protein kinase 0.0113 0.3327 1
Onchocerca volvulus 0.0084 0.234 0.3627
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0197 0.6159 0.6138
Entamoeba histolytica tyrosine kinase, putative 0.0113 0.3327 0.5274
Loa Loa (eye worm) TK/FER protein kinase 0.0197 0.6159 0.6159
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Brugia malayi SH2 domain containing protein 0.0084 0.234 0.221
Loa Loa (eye worm) STAT protein 0.0084 0.234 0.234
Plasmodium vivax protein kinase, putative 0.0113 0.3327 1
Schistosoma mansoni high-affinity choline transporter 0.0311 1 1
Onchocerca volvulus 0.0084 0.234 0.3627
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0113 0.3327 0.5274
Onchocerca volvulus 0.0197 0.6159 1
Brugia malayi Variant SH3 domain containing protein 0.0084 0.234 0.221
Brugia malayi Protein kinase domain containing protein 0.0113 0.3327 0.3214
Entamoeba histolytica protein kinase, putative 0.0113 0.3327 0.5274

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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