Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Homo sapiens | Raf-1 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.2453 | 0.575 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4157 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4087 | 0.9825 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.4087 | 0.9825 | 0.9825 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4157 | 1 | 1 |
Onchocerca volvulus | 0.4157 | 1 | 0.5 | |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4157 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2453 | 0.575 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2383 | 0.5575 | 0.5575 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4157 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4157 | 1 | 1 |
Loa Loa (eye worm) | raf kinase | 0.026 | 0.0279 | 0.0279 |
Giardia lamblia | Hypothetical protein | 0.2453 | 0.575 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2453 | 0.575 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4087 | 0.9825 | 0.9706 |
Brugia malayi | Raf kinase | 0.0253 | 0.026 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4157 | 1 | 1 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0197 | 0.0122 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.2453 | 0.575 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4087 | 0.9825 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4087 | 0.9825 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.4157 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 10.5 uM | Antiproliferative activity against HUVEC after 72 hrs by MTT assay | ChEMBL. | 23726028 |
IC50 (binding) | = 8.6 nM | Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay | ChEMBL. | 23726028 |
IC50 (binding) | > 10000 nM | Inhibition of full length recombinant c-RAF (unknown origin) using MEK1 as substrate after 1 hr by luminescence assay | ChEMBL. | 23726028 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.