Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.2262 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2262 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.2262 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2262 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2262 | 0.5 | 0.5 | |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.2262 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2262 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2262 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2262 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.2262 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.2262 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2262 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.2262 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2262 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.2262 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.2262 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2262 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2262 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.2262 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2262 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2262 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2262 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.2262 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.2262 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.2262 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2262 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.2262 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 21.19 % | Inhibition of recombinant iNOS (unknown origin) assessed as conversion of L-[3H]-arginine to L-[3H]-citrulline at 1 mM after 30 mins | ChEMBL. | 23735830 |
Inhibition (binding) | = 25.93 % | Inhibition of recombinant nNOS (unknown origin) assessed as conversion of L-[3H]-arginine to L-[3H]-citrulline at 1 mM after 30 mins | ChEMBL. | 23735830 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.