TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 545.606 | Formula: C29H27N3O6S
H donors: 1 H acceptors: 6 LogP: 4.41 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCC(C(=O)c1nc2c(o1)cccc2)NC(=O)[C@@H]1C[C@H](CN1C(=O)c1ccccc1)S(=O)(=O)c1ccccc1
InChi: 1S/C29H27N3O6S/c1-2-22(26(33)28-31-23-15-9-10-16-25(23)38-28)30-27(34)24-17-21(39(36,37)20-13-7-4-8-14-20)18-32(24)29(35)19-11-5-3-6-12-19/h3-16,21-22,24H,2,17-18H2,1H3,(H,30,34)/t21-,22?,24+/m1/s1
InChiKey: FSENSIQKQXFHBB-FTPWCCPUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0168	0.0227
Brugia malayi	PHD-finger family protein	0.0025	0.0369	0.0455
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.089	0.12
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0034	0.0777	0.1048
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0065	0.2223	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0034	0.0777	0.1048
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1953	1
Echinococcus granulosus	5'partial\|Low density lipoprotein receptor class A cysteine rich	0.0034	0.0777	0.1048
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.127	0.1713
Brugia malayi	Bromodomain containing protein	0.0075	0.2721	0.364
Schistosoma mansoni	hypothetical protein	0.0021	0.0168	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0034	0.0777	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1953	0.8189
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1953	0.26
Brugia malayi	cathepsin B-like cysteine proteinase	0.0176	0.7418	1
Loa Loa (eye worm)	calcium binding EGF domain-containing protein	0.0034	0.0777	0.1048
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.1953	0.2633
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0029	0.0039
Onchocerca volvulus		0.0041	0.1119	0.2909
Mycobacterium ulcerans	lipase LipD	0.0036	0.089	0.5
Brugia malayi	Bromodomain containing protein	0.0038	0.0998	0.1307
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0034	0.0777	0.1009
Brugia malayi	cathepsin L-like precursor	0.0041	0.1119	0.1471
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Onchocerca volvulus		0.0059	0.1953	1
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0034	0.0777	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1953	0.2633
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.073	0.0985
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Plasmodium vivax	vivapain-2	0.0059	0.1953	1
Onchocerca volvulus		0.0036	0.089	0.0956
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0034	0.0777	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0034	0.0777	0.1048
Leishmania major	cathepsin L-like protease	0.0059	0.1953	0.7972
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0742	0.1001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Giardia lamblia	Cathepsin B precursor	0.0065	0.2223	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.1119	0.2606
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0033	0.0044
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0033	0.073	0.0945
Loa Loa (eye worm)	ctsf protein	0.0059	0.1953	0.2633
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1953	0.26
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0034	0.0777	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0036	0.089	0.12
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.1953	0.26
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.1456	0.1963
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Mycobacterium ulcerans	beta-lactamase	0.0036	0.089	0.5
Echinococcus granulosus	cathepsin L cysteine protease	0.0033	0.073	0.0985
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.127	0.1713
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.089	0.1068
Echinococcus granulosus	geminin	0.0164	0.6872	0.9264
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0059	0.1953	0.2633
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Loa Loa (eye worm)	beta-lactamase	0.0036	0.089	0.12
Echinococcus multilocularis	low density lipoprotein receptor protein	0.0034	0.0777	0.1048
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0034	0.0777	0.1009
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.127	0.1713
Onchocerca volvulus		0.0059	0.1953	1
Brugia malayi	enteropeptidase precursor	0.0034	0.0777	0.1009
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1953	0.26
Brugia malayi	Low-density lipoprotein receptor-related protein, putative	0.0034	0.0777	0.1009
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0041	0.1119	0.1471
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.1953	1
Echinococcus granulosus	cysteine protease	0.0033	0.073	0.0985
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1953	0.26
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1953	0.26
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0034	0.0777	0.1048
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.089	0.1161
Onchocerca volvulus	Cathepsin F homolog	0.0059	0.1953	1
Leishmania major	cathepsin L-like protease	0.0059	0.1953	0.7972
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1953	0.8189
Echinococcus multilocularis	cysteine protease	0.0059	0.1953	0.2633
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Plasmodium vivax	vivapain-3	0.0033	0.073	0.3634
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1001	0.1349
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.7418	1
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0034	0.0777	0.1009
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.1953	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.1953	0.8189
Brugia malayi	CUB domain containing protein	0.0034	0.0777	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0071	0.252	0.3397
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.073	0.0945
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1953	0.8189
Echinococcus multilocularis	cathepsin b	0.0176	0.7418	1
Toxoplasma gondii	cathepsin B	0.0065	0.2223	1
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0034	0.0777	0.1048
Echinococcus granulosus	low density lipoprotein receptor protein	0.0034	0.0777	0.1048
Leishmania major	cathepsin L-like protease	0.0059	0.1953	0.7972
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0034	0.0777	0.1048
Schistosoma mansoni	cathepsin s	0.0018	0.0033	0.0044
Onchocerca volvulus		0.0059	0.1953	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1456	0.1963
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0034	0.0777	0.1048
Brugia malayi	beta-lactamase	0.0036	0.089	0.1161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.1119	0.2606
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0176	0.7418	1
Loa Loa (eye worm)	fibroinase	0.0059	0.1953	0.2633
Leishmania major	cathepsin L-like protease	0.0059	0.1953	0.7972
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.089	0.12
Leishmania major	cathepsin L-like protease	0.0059	0.1953	0.7972
Brugia malayi	Calcium binding EGF domain containing protein	0.0034	0.0777	0.1009
Schistosoma mansoni	hypothetical protein	0.0164	0.6872	0.9264
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1953	0.8189
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0034	0.0777	0.1048
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0034	0.0777	0.1048
Loa Loa (eye worm)	cathepsin B	0.0065	0.2223	0.2997
Leishmania major	cathepsin L-like protease	0.0059	0.1953	0.7972
Echinococcus granulosus	zinc finger protein	0.002	0.0118	0.016
Echinococcus multilocularis	cathepsin L	0.0033	0.073	0.0985
Onchocerca volvulus		0.0036	0.089	0.0956
Giardia lamblia	Cathepsin B precursor	0.0065	0.2223	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0059	0.1953	0.2633
Echinococcus granulosus	Low density lipoprotein receptor class A cysteine rich	0.0034	0.0777	0.1048
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.089	0.1068
Plasmodium vivax	vivapain-1	0.0033	0.073	0.3634
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1953	0.8189
Onchocerca volvulus		0.0059	0.1953	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.089	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.073	0.0945
Loa Loa (eye worm)	hypothetical protein	0.0036	0.089	0.12
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.1953	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1119	0.1509
Brugia malayi	basement membrane proteoglycan precursor	0.0034	0.0777	0.1009
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.089	0.12
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.1953	0.26
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1953	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0258	0.0348
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0036	0.089	0.12
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0176	0.7418	1
Echinococcus multilocularis	zinc finger protein	0.002	0.0118	0.016
Brugia malayi	beta-lactamase family protein	0.0036	0.089	0.1161
Onchocerca volvulus		0.0036	0.089	0.0956
Echinococcus multilocularis	geminin	0.0164	0.6872	0.9264
Trypanosoma cruzi	cysteine proteinase, putative	0.0033	0.073	0.0945
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0034	0.0777	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1119	0.1509
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.1953	0.2633
Loa Loa (eye worm)	cysteine protease	0.0059	0.1953	0.2633
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.2002	0.27
Schistosoma mansoni	hypothetical protein	0.0164	0.6872	0.9264
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.127	0.1713
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.1953	0.26
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.089	0.4464
Giardia lamblia	Cathepsin B precursor	0.0065	0.2223	0.5
Echinococcus granulosus	cathepsin l1	0.0041	0.1119	0.1509
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0065	0.2223	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0742	0.1001
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0065	0.2223	0.2997
Leishmania major	cysteine peptidase A (CPA)	0.0059	0.1953	0.7972
Schistosoma mansoni	hypothetical protein	0.0034	0.0777	0.1048
Schistosoma mansoni	bromodomain containing protein	0.0064	0.2171	0.2926
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1953	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.073	0.0985
Mycobacterium ulcerans	hypothetical protein	0.0036	0.089	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.0059	0.1953	0.26
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1953	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.089	0.12
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0886	0.1195
Toxoplasma gondii	cathepsin CPL	0.0059	0.1953	0.7972
Plasmodium vivax	unspecified product	0.0033	0.073	0.3634
Brugia malayi	Cathepsin L-like precursor	0.0041	0.1119	0.1471
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1953	0.8189
Onchocerca volvulus		0.0059	0.1953	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.089	0.12
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0033	0.0044
Echinococcus granulosus	cathepsin l1	0.0059	0.1953	0.2633
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0034	0.0777	0.1048
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0059	0.1953	1
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.089	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.127	0.1676
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.127	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1112	0.1499
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0059	0.1953	0.2633
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.1953	0.2633
Echinococcus multilocularis	cathepsin b	0.0176	0.7418	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.1953	0.26
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Schistosoma mansoni	zinc finger protein	0.002	0.0118	0.016
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0034	0.0777	0.1048
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1953	0.8189
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.073	0.0945
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Echinococcus granulosus	cathepsin L	0.0033	0.073	0.0985
Trypanosoma cruzi	cysteine protease, putative	0.0033	0.073	0.0945
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1953	0.26
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.1456	0.1928
Leishmania major	cathepsin L-like protease	0.0059	0.1953	0.7972
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0059	0.1953	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1953	0.8189
Leishmania major	cathepsin L-like protease	0.0059	0.1953	0.7972
Echinococcus granulosus	cathepsin b	0.0176	0.7418	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.1953	0.2633
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.089	0.1068
Echinococcus multilocularis	cysteine protease	0.0059	0.1953	0.2633
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1202	0.162
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.089	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0036	0.089	0.12
Schistosoma mansoni	hypothetical protein	0.0034	0.0777	0.1048
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0041	0.1119	0.1471
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1953	0.8189
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0059	0.1953	0.2633
Plasmodium vivax	vivapain-2	0.0059	0.1953	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0065	0.2223	0.2966
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0059	0.1953	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0041	0.1119	0.1509
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.7418	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.089	0.1068
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.089	0.1161
Brugia malayi	Cathepsin L-like precursor	0.0041	0.1119	0.1471
Onchocerca volvulus		0.0059	0.1953	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.127	0.1713
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.127	0.1713
Trichomonas vaginalis	esterase, putative	0.0036	0.089	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0742	0.0961
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0886	0.1195
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.1456	0.1928
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0258	0.0348
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.2002	0.27
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.089	0.1161
Echinococcus granulosus	cathepsin b	0.0176	0.7418	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0258	0.0348
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0176	0.7418	1
Brugia malayi	beta-lactamase family protein	0.0036	0.089	0.1161
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.7418	1
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0034	0.0777	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0033	0.0044
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0034	0.0777	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.089	0.1068
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.1953	0.2633
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.127	0.1713
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0034	0.0777	0.1009
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.1953	0.26
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.089	0.5
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0034	0.0777	0.1009
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0065	0.2223	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.073	0.0985
Trypanosoma cruzi	cysteine proteinase, putative	0.0033	0.073	0.0945
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.1048
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0034	0.0777	0.1048
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0034	0.0777	0.1009
Mycobacterium leprae	Probable lipase LipE	0.0036	0.089	0.5
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0034	0.0777	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0036	0.089	0.12
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0033	0.0044
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0034	0.0777	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1119	0.1509
Onchocerca volvulus		0.0059	0.1953	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.1953	0.2633
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.089	0.12
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1953	0.8189
Entamoeba histolytica	cysteine proteinase, putative	0.0041	0.1119	0.3182

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3 nM	Inhibition of human cathepsin-S	ChEMBL.	23639544
IC50 (binding)	> 10000 nM	Inhibition of human cathepsin-K	ChEMBL.	23639544
IC50 (binding)	> 10000 nM	Inhibition of human cathepsin-B	ChEMBL.	23639544

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2380716

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1764046