Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1261 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1261 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1261 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1261 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1261 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1261 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1261 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1261 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1261 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1261 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 47.2 nM | Inhibition of recombinant human CA9 transmembrane isoform preincubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 23647428 |
Ki (binding) | = 74.7 nM | Inhibition of recombinant human CA12 transmembrane isoform preincubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 23647428 |
Ki (binding) | = 366 nM | Inhibition of recombinant human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 23647428 |
Ki (binding) | = 532 nM | Inhibition of recombinant human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 23647428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.