Detailed information for compound 1764221

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 439.468 | Formula: C21H25N7O4
  • H donors: 2 H acceptors: 6 LogP: 0.54 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ncc(cn1)c1cc2c(C)nc(nc2n(c1=O)[C@@H]1CC[C@@H](CC1)OCC(=O)N)N
  • InChi: 1S/C21H25N7O4/c1-11-15-7-16(12-8-24-21(31-2)25-9-12)19(30)28(18(15)27-20(23)26-11)13-3-5-14(6-4-13)32-10-17(22)29/h7-9,13-14H,3-6,10H2,1-2H3,(H2,22,29)(H2,23,26,27)/t13-,14+
  • InChiKey: VNSCNWLXUYATCI-OKILXGFUSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL No references
Mus musculus phosphatidylinositol 3-kinase, catalytic, alpha polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 1068 aa 927 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0248 0.184 0.184
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0083 0.0474 0.2673
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0061 0.0293 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0092 0.0517
Entamoeba histolytica hypothetical protein 0.0192 0.1374 0.7748
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0034 0.0075 0.0408
Toxoplasma gondii histone deacetylase HDAC3 0.0145 0.099 0.0987
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0061 0.0293 0.0293
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0708 0.0708
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.024 0.1772 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0061 0.0298 0.0298
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0708 0.3997
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0061 0.0298 0.0298
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.0154 0.0154
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0154 0.0856
Toxoplasma gondii fructose-bisphospatase II 0.1237 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0154 0.0154
Brugia malayi hypothetical protein 0.0028 0.0023 0.0023
Trypanosoma brucei histone deacetylase 1 0.0145 0.099 0.099
Schistosoma mansoni tyrosine kinase 0.0029 0.0028 0.0028
Schistosoma mansoni histone deacetylase 1 2 3 0.0041 0.0134 0.0134
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0061 0.0298 0.0298
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0248 0.184 0.184
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0448 0.3491 0.3491
Entamoeba histolytica protein kinase domain containing protein 0.0111 0.0708 0.3987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0091 0.0515
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.046 0.3588 0.3588
Brugia malayi cell division control protein 2 homolog 0.0044 0.0154 0.0154
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0142 0.0799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0091 0.0515
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0034 0.0075 0.0075
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0027 0.0015 0.0015
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0075 0.0075
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.024 0.1772 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0092 0.0517
Echinococcus multilocularis ephrin type A receptor 4 A 0.0208 0.1506 0.1506
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0142 0.0799
Toxoplasma gondii fructose-bisphospatase I 0.046 0.3588 0.3586
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0145 0.099 0.5586
Brugia malayi Histone deacetylase family protein 0.0041 0.0134 0.0134
Echinococcus granulosus histone deacetylase 3 0.0145 0.099 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0183 0.1032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0298 0.1679
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0083 0.0474 0.2673
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0448 0.3491 0.3491
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1237 1 1
Echinococcus granulosus histone deacetylase 7 0.0041 0.0134 0.0134
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0154 0.0154
Echinococcus multilocularis dual specificity protein kinase clk2 0.0061 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0119 0.0772 0.0772
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0293 0.0293
Echinococcus granulosus twitchin 0.0028 0.0024 0.0024
Schistosoma mansoni tyrosine kinase 0.052 0.4083 0.4083
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0154 0.0154
Toxoplasma gondii AGC kinase 0.004 0.0121 0.0118
Leishmania major phosphatidylinositol 3-kinase, putative 0.0034 0.0075 0.0075
Echinococcus granulosus neuroglian 0.0027 0.0015 0.0015
Echinococcus multilocularis Zinc finger, PHD finger 0.0034 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0134
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0134 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0091 0.0515
Loa Loa (eye worm) phosphatidylinositol 3 0.04 0.3092 0.3092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0117 0.0662
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0059 0.0277 0.278
Entamoeba histolytica hypothetical protein 0.0089 0.0523 0.2941
Schistosoma mansoni nephrin 0.0035 0.0085 0.0085
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0421 0.3266 0.3266
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1237 1 1
Trypanosoma cruzi Protein kinase B 0.003 0.0037 0.0037
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.0154 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0206 0.1162
Plasmodium vivax histone deacetylase, putative 0.0041 0.0134 0.1326
Brugia malayi Protein kinase domain containing protein 0.0044 0.0154 0.0154
Schistosoma mansoni tyrosine kinase 0.052 0.4083 0.4083
Onchocerca volvulus Histone deacetylase 10 homolog 0.0041 0.0134 0.0539
Brugia malayi Histone deacetylase 1 0.0145 0.099 0.099
Echinococcus granulosus epidermal growth factor receptor 0.0935 0.7506 0.7506
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.023 0.1685 0.951
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0421 0.3266 0.3266
Echinococcus multilocularis histone deacetylase 3 0.0145 0.099 0.099
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0083 0.0474 0.2661
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0145 0.099 0.5586
Toxoplasma gondii histone deacetylase HDAC2 0.0145 0.099 0.0987
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0034 0.0075 0.0075
Echinococcus multilocularis neuroglian 0.0027 0.0015 0.0015
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0145 0.099 0.5586
Leishmania major histone deacetylase, putative 0.0145 0.099 0.099
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1237 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0072 0.0387 0.0387
Entamoeba histolytica protein kinase, putative 0.0089 0.0523 0.2941
Schistosoma mansoni histone deacetylase 4 5 0.0041 0.0134 0.0134
Entamoeba histolytica protein kinase, putative 0.0111 0.0708 0.3987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.014 0.0793
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0037 0.0195
Echinococcus granulosus histone deacetylase 6 0.0041 0.0134 0.0134
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0083 0.048 0.048
Brugia malayi hypothetical protein 0.0119 0.0772 0.0772
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0708 0.3997
Echinococcus multilocularis epidermal growth factor receptor 0.0935 0.7506 0.7506
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0061 0.0298 0.0298
Echinococcus granulosus roundabout 2 0.0027 0.0015 0.0015
Brugia malayi histone deacetylase 11 0.0041 0.0134 0.0134
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0111 0.0708 0.3987
Plasmodium falciparum histone deacetylase 1 0.0145 0.099 1
Toxoplasma gondii histone deacetylase HDAC1 0.0041 0.0134 0.0131
Echinococcus multilocularis neuroglian 0.0026 0.0003 0.0003
Brugia malayi Protein kinase domain containing protein 0.0089 0.0523 0.0523
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0033 0.0062 0.0062
Echinococcus granulosus serine threonine protein kinase nrc 0.0027 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0171 0.12 0.12
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0154 0.0154
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1237 1 1
Brugia malayi serine/threonine kinase 12 0.0111 0.0708 0.0708
Plasmodium vivax protein kinase Crk2 0.0044 0.0154 0.1535
Schistosoma mansoni tyrosine kinase 0.0532 0.4179 0.4179
Plasmodium falciparum histone deacetylase 2 0.0041 0.0134 0.1326
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.005 0.0206 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0115 0.0647
Loa Loa (eye worm) hypothetical protein 0.009 0.0537 0.0537
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0154 0.0871
Schistosoma mansoni ephrin receptor 0.0182 0.1295 0.1295
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Echinococcus granulosus serine/threonine protein kinase 0.003 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0092 0.0517
Echinococcus multilocularis 0.0058 0.0272 0.0272
Entamoeba histolytica protein kinase, putative 0.0028 0.0024 0.0117
Echinococcus granulosus epidermal growth factor receptor 0.0532 0.4179 0.4179
Echinococcus granulosus hypothetical protein 0.0058 0.0272 0.0272
Trypanosoma brucei histone deacetylase, putative 0.0041 0.0134 0.0134
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.0003 0.0003
Leishmania major protein kinase, putative 0.0061 0.0293 0.0293
Loa Loa (eye worm) AUR protein kinase 0.0111 0.0708 0.0708
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0157 0.1085 0.1085
Schistosoma mansoni nephrin 0.0027 0.0015 0.0015
Trichomonas vaginalis histone deacetylase, putative 0.0145 0.099 0.5586
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0027 0.0017 0.0017
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.046 0.3588 0.3588
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0142 0.0799
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0134
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0448 0.3491 0.3491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0115 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0206 0.1162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0298 0.1679
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0034 0.0075 0.0075
Brugia malayi Fibronectin type III domain containing protein 0.0028 0.0023 0.0023
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0061 0.0293 0.0293
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0015 0.0015
Loa Loa (eye worm) TK/EGFR protein kinase 0.0935 0.7506 0.7506
Entamoeba histolytica protein kinase, putative 0.0111 0.0708 0.3987
Brugia malayi Protein kinase domain containing protein 0.0061 0.0293 0.0293
Plasmodium falciparum serine/threonine protein kinase, putative 0.0111 0.0708 0.7146
Trichomonas vaginalis histone deacetylase, putative 0.0145 0.099 0.5586
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0118 0.0763 0.7696
Echinococcus multilocularis histone deacetylase 6 0.0041 0.0134 0.0134
Echinococcus multilocularis dual specificity 0.0089 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0708 0.3997
Echinococcus granulosus aurora kinase A 0.0111 0.0708 0.0708
Toxoplasma gondii target of rapamycin (TOR), putative 0.0047 0.0183 0.018
Toxoplasma gondii histone deacetylase HDAC5 0.0041 0.0134 0.0131
Trichomonas vaginalis histone deacetylase, putative 0.0145 0.099 0.5586
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0134 0.0134
Plasmodium vivax serine/threonine kinase-1, putative 0.0061 0.0293 0.2939
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0027 0.0017 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0232 0.131
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0003
Brugia malayi p70 ribosomal S6 kinase beta 0.004 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0015 0.0015
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0166 0.1161 0.6552
Brugia malayi Immunoglobulin I-set domain containing protein 0.034 0.26 0.26
Schistosoma mansoni tyrosine kinase 0.052 0.4083 0.4083
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0142 0.0799
Loa Loa (eye worm) AUR protein kinase 0.0111 0.0708 0.0708
Giardia lamblia GTOR 0.0061 0.0298 0.2985
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0092 0.0517
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0111 0.0708 0.0708
Trypanosoma brucei aurora B kinase 0.0111 0.0708 0.0708
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.024 0.1772 0.1772
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0532 0.4179 0.4179
Trypanosoma cruzi rac serine-threonine kinase, putative 0.003 0.0037 0.0037
Echinococcus granulosus histone deacetylase 6 0.0041 0.0134 0.0134
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1237 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.005 0.0206 0.0206
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0154 0.0152
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0108 0.0686 0.3862
Leishmania major histone deacetylase, putative 0.0145 0.099 0.099
Echinococcus granulosus histone deacetylase 0.0041 0.0134 0.0134
Giardia lamblia Histone deacetylase 0.0145 0.099 1
Schistosoma mansoni tyrosine kinase 0.0935 0.7506 0.7506
Brugia malayi Protein kinase domain containing protein 0.0081 0.0459 0.0459
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0034 0.0075 0.0732
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0061 0.0298 0.1665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0183 0.1032
Plasmodium vivax histone deacetylase, putative 0.0041 0.0134 0.1326
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0034 0.0075 0.0072
Echinococcus multilocularis roundabout 2 0.0045 0.0163 0.0163
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0166 0.1161 0.6552
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0154 0.1535
Schistosoma mansoni cell adhesion molecule 0.0038 0.0102 0.0102
Loa Loa (eye worm) TK/INSR protein kinase 0.0411 0.3184 0.3184
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0208 0.1511 0.1511
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0061 0.0298 0.0298
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0061 0.0298 0.0298
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0083 0.0474 0.2661
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0154 0.0871
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0015 0.0015
Brugia malayi Histone deacetylase family protein 0.0041 0.0134 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0183 0.1032
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0154 0.1535
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0034 0.0075 0.0075
Loa Loa (eye worm) histone deacetylase 0.0041 0.0134 0.0134
Schistosoma mansoni histone deacetylase 0.0145 0.099 0.099
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.046 0.3588 0.3588
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0061 0.0293 0.029
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0034 0.0075 0.0424
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0061 0.0293 0.0293
Echinococcus multilocularis endonuclease reverse transcriptase 0.0026 0.0003 0.0003
Loa Loa (eye worm) histone deacetylase 11 0.0041 0.0134 0.0134
Schistosoma mansoni tyrosine kinase 0.0411 0.3184 0.3184
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0154 0.0154
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0157 0.1085 0.1085
Leishmania major 0.1237 1 1
Toxoplasma gondii histone deacetylase HDAC4 0.0041 0.0134 0.0131
Echinococcus granulosus histone deacetylase 1 0.0145 0.099 0.099
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0142 0.0799
Echinococcus granulosus contactin 0.0027 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0117 0.0662
Brugia malayi histone deacetylase 1 (HD1) 0.0145 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0086 0.0503 0.0503
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0154 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0206 0.1162
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0248 0.184 0.184
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0027 0.0017 0.0017
Echinococcus multilocularis histone deacetylase 7 0.0041 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Echinococcus granulosus roundabout 2 0.0027 0.0015 0.0015
Echinococcus multilocularis histone deacetylase 1 0.0145 0.099 0.099
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0028 0.002 0.002
Trypanosoma brucei histone deacetylase 3 0.0041 0.0134 0.0134
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0142 0.0799
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0111 0.0708 0.3987
Schistosoma mansoni histone deacetylase 4 5 0.0041 0.0134 0.0134
Entamoeba histolytica protein kinase, putative 0.0042 0.0142 0.0784
Brugia malayi Furin-like cysteine rich region family protein 0.0935 0.7506 0.7506
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0293 0.0293
Echinococcus granulosus dual specificity 0.0089 0.0523 0.0523
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0111 0.0708 0.3987
Schistosoma mansoni protein kinase 0.0111 0.0708 0.0708
Trypanosoma cruzi aurora B kinase, putative 0.0111 0.0708 0.0708
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0034 0.0075 0.0732
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0083 0.0474 0.0474
Plasmodium vivax histone deacetylase 2, putative 0.0041 0.0134 0.1326
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0154 0.0154
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0134 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0183 0.1032
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0083 0.0474 0.0474
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0027 0.0017 0.0143
Echinococcus granulosus endonuclease reverse transcriptase 0.0026 0.0003 0.0003
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0154 0.0154
Plasmodium falciparum histone deacetylase, putative 0.0041 0.0134 0.1326
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0082
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0083 0.0474 0.0474
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0154 0.0154
Echinococcus granulosus insulin receptor 0.0411 0.3184 0.3184
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0145 0.099 0.099
Echinococcus multilocularis 0.0286 0.2155 0.2155
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0069 0.0363 0.0363
Entamoeba histolytica protein kinase, putative 0.0089 0.0523 0.2941
Echinococcus multilocularis histone deacetylase 6 0.0041 0.0134 0.0134
Echinococcus multilocularis histone deacetylase 6 0.0041 0.0134 0.0134
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0034 0.0075 0.0424
Plasmodium falciparum protein serine/threonine kinase-1 0.0061 0.0293 0.2939
Giardia lamblia Kinase, CMGC CLK 0.0061 0.0293 0.2939
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0206 0.1162
Onchocerca volvulus 0.0301 0.2277 0.9354
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.0003 0.0003
Schistosoma mansoni tyrosine kinase 0.0411 0.3184 0.3184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0298 0.1679
Leishmania major protein kinase, putative 0.0111 0.0708 0.0708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0183 0.1032
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0157 0.1085 0.1085
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0015 0.0015
Loa Loa (eye worm) histone deacetylase 3 0.0145 0.099 0.099
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0075 0.0075
Schistosoma mansoni serine/threonine-protein kinase 0.003 0.0037 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0293 0.1653
Leishmania major protein kinase, putative 0.0061 0.0293 0.0293
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0015 0.0015
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0072 0.0387 0.0387
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0134 0.0134
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0523 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0183 0.1032
Echinococcus granulosus neuroglian 0.0026 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0157 0.1085 0.1085
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0089 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0119 0.0772 0.0772
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.024 0.1772 1
Echinococcus granulosus roundabout 2 0.0045 0.0163 0.0163
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.003 0.0036 0.0036
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0083 0.0474 0.2673
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1237 1 1
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1237 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0034 0.0075 0.0072
Schistosoma mansoni serine/threonine-protein kinase 0.003 0.0037 0.0037
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0154 0.0154
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0034 0.0075 0.0075
Giardia lamblia Kinase, AGC PKA 0.0027 0.0017 0.0143
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.024 0.1772 0.1772
Loa Loa (eye worm) histone deacetylase 7A 0.0041 0.0134 0.0134
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.024 0.1772 0.1772
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0034 0.0075 0.0075
Trypanosoma brucei histone deacetylase 2 0.0041 0.0134 0.0134
Trypanosoma brucei rac serine-threonine kinase, putative 0.0042 0.0142 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0708 0.3997
Trypanosoma brucei histone deacetylase 4 0.0041 0.0134 0.0134
Entamoeba histolytica protein kinase, putative 0.004 0.0121 0.0669
Echinococcus multilocularis insulin receptor 0.0411 0.3184 0.3184
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0154 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.015 0.0847
Echinococcus multilocularis epidermal growth factor receptor 0.0532 0.4179 0.4179
Echinococcus granulosus histone deacetylase 8 0.0041 0.0134 0.0134
Onchocerca volvulus Tyrosine kinase homolog 0.032 0.2434 1
Loa Loa (eye worm) histone deacetylase 1 0.0145 0.099 0.099
Echinococcus multilocularis roundabout 2 0.0027 0.0015 0.0015
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0154 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0183 0.1032
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0061 0.0293 0.0293
Loa Loa (eye worm) phosphatidylinositol 3 0.0061 0.0298 0.0298
Schistosoma mansoni histone deacetylase 0.0145 0.099 0.099
Schistosoma mansoni histone deacetylase hda2 0.0041 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Trypanosoma cruzi histone deacetylase 1, putative 0.0145 0.099 0.099
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.004 0.0121 0.0121
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0111 0.0708 0.7146
Echinococcus multilocularis roundabout 2 0.0027 0.0015 0.0015
Plasmodium vivax histone deacetylase 1, putative 0.0145 0.099 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0145 0.099 0.099
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.0523 0.0523
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0089 0.0523 0.0523
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0027 0.0015 0.0015
Brugia malayi serine/threonine protein kinase 6 0.0111 0.0708 0.0708
Trichomonas vaginalis histone deacetylase, putative 0.0145 0.099 0.5586
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0154 0.0154
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0154 0.0154
Leishmania major histone deacetylase, putative 0.0041 0.0134 0.0134
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0134 0.0134
Loa Loa (eye worm) AGC/AKT protein kinase 0.0042 0.0142 0.0142
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.0003 0.0003
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.0154 0.0154
Schistosoma mansoni cell adhesion molecule 0.0027 0.0015 0.0015
Entamoeba histolytica protein kinase , putative 0.0111 0.0708 0.3987
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.024 0.1772 1
Brugia malayi ephrin receptor 1 precursor 0.0092 0.0551 0.0551
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0061 0.0298 0.0298
Trichomonas vaginalis histone deacetylase, putative 0.0145 0.099 0.5586
Echinococcus granulosus dual specificity protein kinase clk2 0.0061 0.0293 0.0293
Schistosoma mansoni histone deacetylase hda2 0.0041 0.0134 0.0134
Echinococcus granulosus ephrin type A receptor 4 A 0.0208 0.1506 0.1506
Plasmodium falciparum protein kinase 5 0.0044 0.0154 0.1535
Entamoeba histolytica histone deacetylase, putative 0.0145 0.099 0.5579
Loa Loa (eye worm) hypothetical protein 0.0086 0.0503 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0117 0.0662
Brugia malayi Protein kinase domain containing protein 0.0411 0.3184 0.3184
Trichomonas vaginalis histone deacetylase, putative 0.0145 0.099 0.5586
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0061 0.0298 0.0298
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.0154 0.0154
Entamoeba histolytica protein kinase, putative 0.0042 0.0142 0.0784
Loa Loa (eye worm) TK/KIN16 protein kinase 0.034 0.26 0.26
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0142 0.0799
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0061 0.0293 0.0293
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0089 0.0523 0.0523
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0027 0.0017 0.0017
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.0523 0.2941
Toxoplasma gondii aurora kinase 0.0111 0.0708 0.0706
Echinococcus multilocularis histone deacetylase 0.0041 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0154 0.0871
Brugia malayi Protein kinase domain containing protein 0.0042 0.0142 0.0142
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0061 0.0293 0.0293
Brugia malayi histone deacetylase 3 (HD3) 0.0145 0.099 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0206 0.1162
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0061 0.0298 0.0298
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0023 0.0023
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0192 0.1374 0.7748
Trypanosoma brucei target of rapamycin kinase 3, putative 0.005 0.0206 0.0206
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.0523 0.0523
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0154 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0015 0.0015
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0037 0.0195
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0015 0.0015
Loa Loa (eye worm) TK/EPH protein kinase 0.0229 0.1681 0.1681
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0029 0.0035 0.0035
Echinococcus multilocularis aurora kinase A 0.0111 0.0708 0.0708
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0111 0.0708 0.0708
Schistosoma mansoni tyrosine kinase 0.0532 0.4179 0.4179
Onchocerca volvulus 0.0171 0.12 0.4923
Brugia malayi serine/threonine-protein kinase 6 0.0111 0.0708 0.0708
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0034 0.0075 0.0075
Schistosoma mansoni cell adhesion molecule 0.0027 0.0015 0.0015
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0034 0.0075 0.0424
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0061 0.0298 0.0298
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.046 0.3588 0.3586
Echinococcus multilocularis histone deacetylase 8 0.0041 0.0134 0.0134
Entamoeba histolytica protein kinase 2, putative 0.0027 0.0017 0.008
Loa Loa (eye worm) AUR protein kinase 0.0111 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0082
Leishmania major histone deacetylase, putative 0.0041 0.0134 0.0134
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0061 0.0298 0.1665
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0027 0.0015 0.0015
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0083 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0248 0.184 0.184
Echinococcus granulosus histone deacetylase 6 0.0041 0.0134 0.0134
Giardia lamblia Aurora kinase 0.0111 0.0708 0.7146
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0034 0.0075 0.0408
Loa Loa (eye worm) hypothetical protein 0.0058 0.0272 0.0272
Echinococcus multilocularis rac serine:threonine kinase 0.003 0.0037 0.0037
Schistosoma mansoni neuroglian 0.0027 0.0015 0.0015

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.62 nM BindingDB_Patents: Biochemical Assay. Compounds of the present invention were evaluated for potency against PI3-Ka using an in vitro kinase assay. PI3-Ka activity is measured in vitro by determining the level of phosphorylation of the substrate PI(4,5)P2. The formation of product PI(3,4,5)P3 is monitored by binding to the Grip1 PH domain in a ligand displacement fluorescence polarization (FP) assay, in which the TAMRA-labeled PI(3,4,5)P3 complexed with Grip1 PH domain is displaced by PI(3,4,5)P3 formed in the PI3-Ka reaction resulting in a decrease in FP signal. ChEMBL. No reference
IC50 (binding) = 3.62 nM BindingDB_Patents: Biochemical Assay. Compounds of the present invention were evaluated for potency against PI3-Ka using an in vitro kinase assay. PI3-Ka activity is measured in vitro by determining the level of phosphorylation of the substrate PI(4,5)P2. The formation of product PI(3,4,5)P3 is monitored by binding to the Grip1 PH domain in a ligand displacement fluorescence polarization (FP) assay, in which the TAMRA-labeled PI(3,4,5)P3 complexed with Grip1 PH domain is displaced by PI(3,4,5)P3 formed in the PI3-Ka reaction resulting in a decrease in FP signal. ChEMBL. No reference
IC50 (binding) = 82.9 nM Inhibition of AKT phosphorylation at Ser 473 in human BT20 cells ChEMBL. 23506825
Ki (binding) = 1.82 nM Inhibition of mouse PI3Kalpha ChEMBL. 23506825
Ki (binding) = 12.6 nM Inhibition of mTOR (unknown origin) ChEMBL. 23506825

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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