Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.2594 | 0.4799 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.432 | 0.9786 | 0.9786 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4395 | 1 | 1 |
Brugia malayi | DNA topoisomerase I | 0.1245 | 0.0903 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.432 | 0.9786 | 0.9764 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1875 | 0.2724 | 0.2724 |
Loa Loa (eye worm) | hypothetical protein | 0.4395 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.432 | 0.9786 | 0.9786 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.1245 | 0.0903 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2594 | 0.4799 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1875 | 0.2724 | 0.2724 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1875 | 0.2724 | 0.2724 |
Mycobacterium ulcerans | hypothetical protein | 0.2594 | 0.4799 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2519 | 0.4585 | 0.4047 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4395 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2594 | 0.4799 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4395 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4395 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4395 | 1 | 1 |
Plasmodium falciparum | topoisomerase I | 0.1245 | 0.0903 | 0.5 |
Onchocerca volvulus | 0.4395 | 1 | 0.5 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.432 | 0.9786 | 0.9786 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.432 | 0.9786 | 0.9786 |
Schistosoma mansoni | DNA topoisomerase type I | 0.1245 | 0.0903 | 0.0903 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2594 | 0.4799 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4395 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.1875 | 0.2724 | 0.2724 |
Plasmodium vivax | topoisomerase I, putative | 0.1245 | 0.0903 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 180 uM | Inhibition of BACE1 (unknown origin) expressed in CHO cells coexpressing human APP gene assessed as inhibition of beta-amyloid synthesis | ChEMBL. | 24835197 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.