Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0079 | 0.0038 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0104 | 0.0079 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0104 | 0.0079 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0104 | 0.0079 | 0.5 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0104 | 0.0079 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0104 | 0.0079 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.5 |
Echinococcus multilocularis | geminin | 0.0379 | 0.053 | 0.0491 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0104 | 0.0079 | 0.2528 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0104 | 0.0079 | 0.0038 |
Plasmodium vivax | phosphoglucomutase-2, putative | 0.0104 | 0.0079 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase PGMII | 0.0104 | 0.0079 | 0.5 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.0128 | 0.0128 |
Treponema pallidum | phosphoglyceromutase | 0.0104 | 0.0079 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.6145 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.6041 | 0.983 | 0.9828 |
Schistosoma mansoni | ets-related | 0.0246 | 0.0312 | 0.0272 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.6145 | 1 | 1 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0079 | 0.0079 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0104 | 0.0079 | 0.2528 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0104 | 0.0079 | 0.5 |
Brugia malayi | UBASH3A protein homolog | 0.0104 | 0.0079 | 0.2528 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0081 | 0.0041 | 0.0041 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Brugia malayi | Fli-1 protein | 0.0246 | 0.0312 | 1 |
Plasmodium vivax | phosphoglycerate mutase, putative | 0.0104 | 0.0079 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.2622 | 0.4215 | 0.4169 |
Mycobacterium tuberculosis | Conserved protein | 0.0104 | 0.0079 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0079 | 0.0038 |
Plasmodium falciparum | phosphoglucomutase-2 | 0.0104 | 0.0079 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0104 | 0.0079 | 0.5 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0104 | 0.0079 | 0.5 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0079 | 0.0079 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0079 | 0.0038 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0079 | 0.0038 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.6145 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0104 | 0.0079 | 0.0038 |
Loa Loa (eye worm) | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.3523 | 0.5694 | 0.5694 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Echinococcus granulosus | geminin | 0.0379 | 0.053 | 0.0491 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2622 | 0.4215 | 0.4169 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.6041 | 0.983 | 0.9828 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.053 | 0.0491 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0104 | 0.0079 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.6145 | 1 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0081 | 0.0041 | 0.1327 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2622 | 0.4215 | 0.4169 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.6145 | 1 | 1 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0104 | 0.0079 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.3627 | 0.5864 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0079 | 0.0079 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Plasmodium falciparum | phosphoglycerate mutase, putative | 0.0104 | 0.0079 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0079 | 0.0038 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0104 | 0.0079 | 0.5 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.6145 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0104 | 0.0079 | 0.5 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0104 | 0.0079 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0104 | 0.0079 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.3627 | 0.5864 | 1 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0104 | 0.0079 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.3627 | 0.5864 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.0128 | 0.0128 |
Mycobacterium tuberculosis | Conserved protein | 0.0104 | 0.0079 | 0.5 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0104 | 0.0079 | 0.0038 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.0128 | 0.409 |
Loa Loa (eye worm) | hypothetical protein | 0.6041 | 0.983 | 0.983 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0104 | 0.0079 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 0.0079 | 0.5 |
Onchocerca volvulus | 0.6145 | 1 | 1 | |
Giardia lamblia | Hypothetical protein | 0.3627 | 0.5864 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0906 | 0.1397 | 0.1361 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0104 | 0.0079 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.053 | 0.0491 |
Mycobacterium leprae | conserved hypothetical protein | 0.0104 | 0.0079 | 0.5 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0104 | 0.0079 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0104 | 0.0079 | 0.5 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Loa Loa (eye worm) | fli-1 protein | 0.0246 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0022 | 0.0022 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 0.0079 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0104 | 0.0079 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2622 | 0.4215 | 0.4169 |
Mycobacterium ulcerans | hypothetical protein | 0.3627 | 0.5864 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.6041 | 0.983 | 0.9828 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0104 | 0.0079 | 0.0038 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0104 | 0.0079 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0081 | 0.0041 | 0.1327 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0079 | 0.0038 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0104 | 0.0079 | 0.5 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0104 | 0.0079 | 0.0038 |
Schistosoma mansoni | 6-phosphofructokinase | 0.6145 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.6041 | 0.983 | 0.9828 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0104 | 0.0079 | 0.5 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0104 | 0.0079 | 0.5 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0104 | 0.0079 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 100 uM | Cytotoxicity against human K562 cells after 96 hrs by trypan blue exclusion assay | ChEMBL. | 23750455 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.