Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.566 | 0.566 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.566 | 0.566 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.566 | 0.566 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.566 | 0.566 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.566 | 0.566 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.566 | 0.566 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0094 | 1 | 1 |
Onchocerca volvulus | 0.0063 | 0.566 | 0.566 | |
Brugia malayi | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0063 | 0.566 | 0.566 |
Brugia malayi | Peroxidasin | 0.0063 | 0.566 | 0.566 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.566 | 0.566 |
Brugia malayi | Blistered cuticle protein 3 | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Onchocerca volvulus | Dual oxidase homolog | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Onchocerca volvulus | 0.0063 | 0.566 | 0.566 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.566 | 0.566 |
Echinococcus granulosus | peroxidasin | 0.0063 | 0.566 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.566 | 0.566 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Echinococcus multilocularis | peroxidasin | 0.0063 | 0.566 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Onchocerca volvulus | 0.0094 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.8375 | 0.8375 |
Onchocerca volvulus | 0.0094 | 1 | 1 | |
Onchocerca volvulus | 0.0094 | 1 | 1 | |
Onchocerca volvulus | 0.0063 | 0.566 | 0.566 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0063 | 0.566 | 0.566 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0094 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.566 | 0.566 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.566 | 0.566 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.27 uM | Inhibition of COX-1 in human whole blood assessed as inhibition of serum TXB2 level after 1 hr by radioimmunoassay | ChEMBL. | 23651359 |
IC50 (binding) | = 1.1 uM | Inhibition of COX-2 in human whole blood assessed as inhibition of LPS-induced plasma PGE2 level by radioimmunoassay | ChEMBL. | 23651359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.