Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.7897 | 0.7897 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0181 | 0.6616 | 0.6616 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0248 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Onchocerca volvulus | 0.0156 | 0.5329 | 0.5 | |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0248 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.376 | 0.376 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.7145 | 0.7145 |
Schistosoma mansoni | atypical protein kinase C | 0.0086 | 0.1816 | 0.1816 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0181 | 0.6616 | 0.6616 |
Echinococcus multilocularis | protein kinase c iota type | 0.0086 | 0.1816 | 0.1816 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0089 | 0.1944 | 0.1944 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0089 | 0.1944 | 0.1944 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.5329 | 0.5329 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.5329 | 0.5329 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0181 | 0.6616 | 0.6616 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0086 | 0.1816 | 0.1816 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0089 | 0.1944 | 0.1944 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.1944 | 0.1944 |
Brugia malayi | Protein kinase c protein 2 | 0.0131 | 0.4103 | 0.4103 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0145 | 0.48 | 0.48 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0206 | 0.7897 | 0.7897 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0157 | 0.5384 | 0.5384 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.0051 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0145 | 0.48 | 0.48 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 1 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0181 | 0.6616 | 0.6616 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0248 | 1 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0157 | 0.5384 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.5329 | 0.5329 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0096 | 0.2287 | 0.2287 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 110 ug ml-1 | Cytotoxicity against mouse NIH/3T3 cells by MTT assay | ChEMBL. | 23511017 |
IC50 (ADMET) | > 200 ug ml-1 | Cytotoxicity against human HeLa cells by MTT assay | ChEMBL. | 23511017 |
MIC (functional) | = 500 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 by broth dilution method | ChEMBL. | 23511017 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.