Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0079 | 0.2388 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0134 | 0.6292 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0079 | 0.2397 | 0.381 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0101 | 0.3952 | 0.5865 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0134 | 0.6292 | 0.6292 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.7801 | 0.7801 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0048 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.9356 | 0.9356 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0079 | 0.2388 | 0.3795 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0109 | 0.4539 | 0.7214 |
Onchocerca volvulus | 0.0156 | 0.7801 | 0.5 | |
Brugia malayi | protein kinase C II. | 0.0134 | 0.6292 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0101 | 0.3952 | 0.6281 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.7801 | 0.7801 |
Echinococcus multilocularis | protein kinase c iota type | 0.0054 | 0.0633 | 0.1006 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0134 | 0.6292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.7801 | 0.7801 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0101 | 0.3952 | 0.6281 |
Echinococcus granulosus | protein kinase C gamma type | 0.0079 | 0.2397 | 0.381 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0101 | 0.3952 | 0.5865 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1555 | 0.1555 |
Echinococcus granulosus | protein kinase c iota type | 0.0054 | 0.0633 | 0.1006 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0134 | 0.6292 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 52 ug ml-1 | Cytotoxicity against mouse NIH/3T3 cells by MTT assay | ChEMBL. | 23511017 |
IC50 (ADMET) | > 200 ug ml-1 | Cytotoxicity against human HeLa cells by MTT assay | ChEMBL. | 23511017 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 by broth dilution method | ChEMBL. | 23511017 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.