Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 protease | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.3337 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3337 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.3337 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3337 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3337 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3337 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.3337 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.3337 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.3337 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3337 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3337 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.3337 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.3337 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3337 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.3337 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.3337 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.3337 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.3337 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.3337 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.3337 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Inhibition of cytopathic effect of HIV-1 strain RF in MT-4 cell culture | ChEMBL. | 8230098 |
EC50 (functional) | > 100 uM | Inhibition of cytopathic effect of HIV-1 strain RF in MT-4 cell culture | ChEMBL. | 8230098 |
IC50 (binding) | = 39 nM | Inhibitory activity against HIV-1 Protease | ChEMBL. | 8230098 |
IC50 (binding) | = 39 nM | Inhibitory activity against HIV-1 Protease | ChEMBL. | 8230098 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.