Detailed information for compound 1765633

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 609.687 | Formula: C37H60BNO5
  • H donors: 1 H acceptors: 2 LogP: 8.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: O/N=C\1/C[C@@H]2[C@@]3(C)CC=C(C([C@@H]3CC[C@]2([C@]2([C@H]1[C@@H]1CC(C)(C)CC[C@@]1(CC2)C(=O)OC)C)C)(C)C)B1OC(C(O1)(C)C)(C)C
  • InChi: 1S/C37H60BNO5/c1-30(2)17-19-37(29(40)42-12)20-18-36(11)28(23(37)22-30)24(39-41)21-26-34(9)15-14-27(38-43-32(5,6)33(7,8)44-38)31(3,4)25(34)13-16-35(26,36)10/h14,23,25-26,28,41H,13,15-22H2,1-12H3/b39-24-/t23-,25-,26+,28-,34-,35+,36+,37-/m0/s1
  • InChiKey: HOXXTNNDRGVTBL-IYEXNMPBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0.0071 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.2249 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.3242 0.8068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1337 0.5946
Leishmania major cathepsin L-like protease 0.0034 0.2249 0.2249
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0304 0.0323
Leishmania major cathepsin L-like protease 0.0128 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0403 0.0429
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.2249 0.5598
Brugia malayi Cathepsin L-like precursor 0.0034 0.2249 0.6938
Mycobacterium leprae putative cytochrome p450 0.0007 0.0071 0.5
Brugia malayi Cathepsin L-like precursor 0.0034 0.2249 0.6938
Leishmania major cathepsin L-like protease 0.0034 0.2249 0.2249
Loa Loa (eye worm) cytochrome P450 0.0007 0.0071 0.0076
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0.0071 0.5
Leishmania major cytochrome p450-like protein 0.0016 0.079 0.079
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.2249 0.5598
Onchocerca volvulus 0.0034 0.2249 1
Schistosoma mansoni rab6-interacting 0.002 0.1108 0.2757
Loa Loa (eye worm) hypothetical protein 0.0011 0.0403 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.2249 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.2249 0.6938
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.1108 0.4926
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0.0071 0.5
Onchocerca volvulus 0.0034 0.2249 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0912 0.2269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.2249 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0.0071 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0912 0.0912
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.2249 0.5598
Schistosoma mansoni polycystin 1-related 0.002 0.1108 0.2757
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0912 0.2269
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0.0071 0.5
Leishmania major cathepsin L-like protease 0.0034 0.2249 0.2249
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.002 0.1108 0.1179
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0912 0.2813
Onchocerca volvulus 0.0034 0.2249 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0.0071 0.5
Schistosoma mansoni loxhd1 0.002 0.1108 0.2757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0912 0.4054
Echinococcus multilocularis RUN 0.002 0.1108 0.2757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Trypanosoma brucei cytochrome P450, putative 0.0016 0.079 0.079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.4018 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Leishmania major cytochrome p450-like protein 0.0007 0.0071 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.2249 0.2393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0912 0.4054
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0543 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0.0071 0.5
Onchocerca volvulus 0.0034 0.2249 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0822 0.3655
Echinococcus granulosus cathepsin l1 0.0022 0.1337 0.3328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.2249 1
Brugia malayi cytochrome P450 0.0007 0.0071 0.022
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.2249 0.5598
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0403 0.1243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.3242 0.8068
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0007 0.0071 0.0071
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.2249 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.1108 0.2757
Plasmodium vivax unspecified product 0.0017 0.0912 0.4054
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0.0071 0.5
Loa Loa (eye worm) RecQ helicase 0.0024 0.146 0.1553
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0912 0.2269
Plasmodium vivax vivapain-2 0.0034 0.2249 1
Echinococcus granulosus bloom syndrome protein 0.0024 0.146 0.3632
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0912 0.4054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.3242 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0.0071 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0912 0.0912
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0.0071 0.0318
Schistosoma mansoni cathepsin s 0.0011 0.0403 0.1003
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0.0071 0.5
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.9088 0.9088
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0.0071 0.5
Leishmania major cathepsin L-like protease 0.0128 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.079 0.084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1337 0.5946
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0.0071 0.5
Echinococcus multilocularis 0.0007 0.0071 0.0178
Loa Loa (eye worm) doublecortin family protein 0.002 0.1108 0.1179
Plasmodium falciparum LCCL domain-containing protein 0.002 0.1108 0.4926
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0034 0.2249 1
Trypanosoma cruzi cruzipain precursor, putative 0.0011 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0009 0.0209 0.0223
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.7751 0.7751
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Onchocerca volvulus 0.002 0.1108 0.4926
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.3242 0.8068
Brugia malayi Cytochrome P450 family protein 0.0026 0.1636 0.5047
Brugia malayi Cathepsin L-like precursor 0.0022 0.1337 0.4125
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0007 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.002 0.1108 0.2757
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0912 0.4054
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.146 0.4502
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.2249 0.2249
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.2249 0.5598
Brugia malayi Cytochrome P450 family protein 0.0016 0.079 0.2436
Echinococcus granulosus cathepsin l1 0.0034 0.2249 0.5598
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0912 0.4054
Loa Loa (eye worm) hypothetical protein 0.002 0.1108 0.1179
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0403 0.1243
Trypanosoma cruzi cruzipain precursor, putative 0.0128 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.2249 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0912 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.3242 0.8068
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0912 0.2269
Leishmania major cysteine peptidase A (CPA) 0.0034 0.2249 0.2249
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0304 0.135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0912 0.0912
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.4018 1
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0912 0.0912
Onchocerca volvulus 0.002 0.1108 0.4926
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Echinococcus granulosus cysteine protease 0.0017 0.0912 0.2269
Plasmodium vivax vivapain-3 0.0017 0.0912 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.2249 0.5598
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.2249 1
Plasmodium vivax vivapain-1 0.0017 0.0912 0.4054
Echinococcus multilocularis cathepsin L 0.0017 0.0912 0.2269
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0912 0.0912
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Loa Loa (eye worm) hypothetical protein 0.0022 0.1337 0.1423
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.1221 0.5426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.3242 0.8068
Echinococcus multilocularis cysteine protease 0.0034 0.2249 0.5598
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.2249 1
Loa Loa (eye worm) ctsf protein 0.0034 0.2249 0.2393
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0007 0.0071 0.0071
Brugia malayi Cytochrome P450 family protein 0.0007 0.0071 0.022
Brugia malayi Cathepsin L-like precursor 0.0022 0.1337 0.4125
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0.0071 0.5
Loa Loa (eye worm) fibroinase 0.0034 0.2249 0.2393
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0304 0.135
Brugia malayi Cathepsin L-like precursor 0.0011 0.0403 0.1243
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.1636 0.1741
Brugia malayi cathepsin L-like precursor 0.0022 0.1337 0.4125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.2249 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.2249 1
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.1108 0.2757
Echinococcus granulosus cathepsin L 0.0017 0.0912 0.2269
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.079 0.084
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.1108 0.2757
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.1045 0.2602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.2249 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0071 0.0178
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0071 0.0071
Schistosoma mansoni DNA helicase recq5 0.001 0.0304 0.0756
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0.0071 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0304 0.0937
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.2249 0.5598
Brugia malayi Cathepsin L-like precursor 0.0034 0.2249 0.6938
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0912 0.0912
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.2249 1
Onchocerca volvulus 0.0034 0.2249 1
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.1337 0.3328
Leishmania major cathepsin L-like protease 0.0034 0.2249 0.2249
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0.0071 0.5
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.146 0.6489
Loa Loa (eye worm) hypothetical protein 0.0011 0.0403 0.0429
Onchocerca volvulus 0.0034 0.2249 1
Brugia malayi Doublecortin family protein 0.002 0.1108 0.3417
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.2249 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0543 0.2413
Loa Loa (eye worm) hypothetical protein 0.0022 0.1337 0.1423
Onchocerca volvulus Cathepsin F homolog 0.0034 0.2249 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0304 0.0937
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.079 0.079
Schistosoma mansoni rab6-interacting 0.002 0.1108 0.2757
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0912 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.2249 1
Toxoplasma gondii cathepsin CPL 0.0034 0.2249 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0806 0.3585
Leishmania major cathepsin L-like protease 0.0034 0.2249 0.2249
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Trypanosoma cruzi cysteine peptidase, putative 0.0128 1 1
Plasmodium vivax unspecified product 0.0011 0.0403 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Echinococcus granulosus RUN 0.002 0.1108 0.2757
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.079 0.079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Loa Loa (eye worm) cysteine protease 0.0034 0.2249 0.2393
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.1337 0.5946
Schistosoma mansoni lipoxygenase 0.0055 0.4018 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0543 0.0543
Schistosoma mansoni DNA helicase recq1 0.001 0.0304 0.0756
Leishmania major cytochrome p450-like protein 0.0007 0.0071 0.0071
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0.0071 0.5
Brugia malayi hypothetical protein 0.002 0.1108 0.3417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.3242 0.8068
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0304 0.0756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0543 0.2413
Schistosoma mansoni lipoxygenase 0.002 0.1108 0.2757
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0.0071 0.5
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.1108 0.2757
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.1108 0.2757
Echinococcus multilocularis bloom syndrome protein 0.0024 0.146 0.3632
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0304 0.135
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0304 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.2249 0.2393
Onchocerca volvulus Cathepsin L homolog 0.0034 0.2249 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.2249 1
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.2249 0.6938
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0304 0.0756
Onchocerca volvulus 0.0022 0.1337 0.5946
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.146 0.6489
Loa Loa (eye worm) hypothetical protein 0.0022 0.1337 0.1423
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0304 0.0756
Plasmodium vivax vivapain-2 0.0034 0.2249 1
Schistosoma mansoni cytochrome P450 0.0007 0.0071 0.0178
Brugia malayi Cathepsin L-like precursor 0.0034 0.2249 0.6938
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0912 0.0912
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0912 0.4054
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0304 0.0756
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.3242 0.8068
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0007 0.0071 0.0178
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0912 0.2813
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0.0071 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.2249 0.5598
Trypanosoma cruzi cysteine peptidase, putative 0.0011 0.0403 0.0403
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0.0071 0.5
Echinococcus multilocularis cysteine protease 0.0034 0.2249 0.5598
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.1108 0.2757
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.2249 0.2393
Loa Loa (eye worm) hypothetical protein 0.001 0.0304 0.0323
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.3242 0.3449
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.079 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0.0071 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0912 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.2249 1
Onchocerca volvulus 0.0034 0.2249 1
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0128 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.2249 1
Brugia malayi hypothetical protein 0.002 0.1108 0.3417
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.1337 0.4125
Mycobacterium leprae Conserved hypothetical protein 0.0007 0.0071 0.5
Entamoeba histolytica cysteine protease, putative 0.0034 0.2249 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0403 0.0429
Loa Loa (eye worm) CYP4Cod1 0.0016 0.079 0.084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 1 1
Brugia malayi Cytochrome P450 family protein 0.0016 0.079 0.2436
Entamoeba histolytica cysteine protease, putative 0.0017 0.0912 0.4054
Brugia malayi Cathepsin L-like precursor 0.0034 0.2249 0.6938
Trypanosoma cruzi cysteine peptidase, putative 0.0128 1 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.94 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 50 uM Cytotoxicity against human SW480 cells assessed as growth inhibition after 48 hrs by MTT assay ChEMBL. 23455056

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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