Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoglyceride lipase | Starlite/ChEMBL | References |
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Plasmodium falciparum | esterase, putative | monoglyceride lipase | 303 aa | 254 aa | 19.7 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0274 | 0.9699 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.4127 | 0.4256 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.4127 | 0.4127 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0.0139 | 0.5 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0139 | 0.0143 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.2695 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.2695 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0.2695 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2695 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0.0139 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.4127 | 0.4256 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.2695 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.4127 | 0.4256 |
Plasmodium vivax | PST-A protein | 0.0084 | 0.2695 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.2695 | 0.5 |
Brugia malayi | amidase | 0.0123 | 0.4127 | 0.4045 |
Schistosoma mansoni | tyrosine kinase | 0.0274 | 0.9699 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.2695 | 1 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0274 | 0.9699 | 1 |
Loa Loa (eye worm) | amidase | 0.0015 | 0.0139 | 0.0139 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2695 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0282 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.2695 | 1 |
Loa Loa (eye worm) | amidase | 0.0015 | 0.0139 | 0.0139 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2695 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0015 | 0.0139 | 0.0143 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0139 | 0.0143 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0139 | 0.5 |
Schistosoma mansoni | amidase | 0.0123 | 0.4127 | 0.4256 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0015 | 0.0139 | 0.0143 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.2695 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2695 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0015 | 0.0139 | 0.0143 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0.2695 | 1 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0274 | 0.9699 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0015 | 0.0139 | 0.0143 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0084 | 0.2695 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2695 | 0.5 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0274 | 0.9699 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.2695 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0084 | 0.2695 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0.2695 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.4127 | 0.4256 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0.2695 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0.2695 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.4127 | 0.4256 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.2695 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0084 | 0.2695 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.029 uM | Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic acid preincubated for 10 mins measured after 45 mins by HPLC analysis | ChEMBL. | 23455058 |
IC50 (binding) | = 0.11 uM | Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for 15 mins measured after 45 mins by HPLC analysis | ChEMBL. | 23455058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.