Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dual oxidase homolog | 0.0912 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0912 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0372 | 0.3395 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0912 | 1 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0372 | 0.3395 | 0.5 |
Schistosoma mansoni | septate junction protein | 0.0101 | 0.0077 | 0.0077 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0912 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0912 | 1 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0372 | 0.3395 | 0.5 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0101 | 0.0077 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0372 | 0.3395 | 0.5 |
Schistosoma mansoni | amidase | 0.044 | 0.4226 | 0.4226 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0372 | 0.3395 | 0.5 |
Schistosoma mansoni | notch | 0.0101 | 0.0077 | 0.0077 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0372 | 0.3395 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.044 | 0.4226 | 0.4181 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0912 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0077 | 0.0077 |
Onchocerca volvulus | 0.0912 | 1 | 1 | |
Schistosoma mansoni | slit | 0.0101 | 0.0077 | 0.0077 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0372 | 0.3395 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0912 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0372 | 0.3395 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0372 | 0.3395 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0372 | 0.3395 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.044 | 0.4226 | 0.4181 |
Echinococcus granulosus | peroxidasin | 0.0912 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0912 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0912 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0372 | 0.3395 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0372 | 0.3395 | 0.5 |
Brugia malayi | amidase | 0.044 | 0.4226 | 0.4181 |
Plasmodium vivax | PST-A protein | 0.0372 | 0.3395 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0372 | 0.3395 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0077 | 0.0077 |
Brugia malayi | Animal haem peroxidase family protein | 0.0912 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0135 | 0.0498 | 0.0498 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0135 | 0.0498 | 0.0424 |
Brugia malayi | Animal haem peroxidase family protein | 0.0912 | 1 | 1 |
Onchocerca volvulus | 0.0912 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0077 | 0.0077 |
Schistosoma mansoni | notch | 0.0101 | 0.0077 | 0.0077 |
Plasmodium falciparum | lysophospholipase, putative | 0.0372 | 0.3395 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0077 | 0.0077 |
Schistosoma mansoni | notch | 0.0101 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0912 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Leishmania major | monoglyceride lipase, putative | 0.0372 | 0.3395 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0912 | 1 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0372 | 0.3395 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0135 | 0.0498 | 0.0424 |
Schistosoma mansoni | cell polarity protein | 0.0101 | 0.0077 | 0.0077 |
Onchocerca volvulus | 0.0912 | 1 | 1 | |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0372 | 0.3395 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Schistosoma mansoni | notch | 0.0101 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.4226 | 0.4181 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Schistosoma mansoni | notch | 0.0101 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.044 | 0.4226 | 0.4226 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0912 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0912 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0912 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0372 | 0.3395 | 0.5 |
Giardia lamblia | High cysteine protein | 0.0101 | 0.0077 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0372 | 0.3395 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0077 | 0.0077 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0372 | 0.3395 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0912 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.044 | 0.4226 | 0.4181 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 1 | 1 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0101 | 0.0077 | 0.0077 |
Brugia malayi | Animal haem peroxidase family protein | 0.0912 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0077 | 0.0077 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.044 | 0.4226 | 0.4181 |
Plasmodium falciparum | lysophospholipase, putative | 0.0372 | 0.3395 | 0.5 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0101 | 0.0077 | 0.0077 |
Schistosoma mansoni | peroxidasin | 0.0912 | 1 | 1 |
Schistosoma mansoni | notch | 0.0101 | 0.0077 | 0.0077 |
Mycobacterium ulcerans | lysophospholipase | 0.0372 | 0.3395 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0912 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0912 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antinociceptive activity in BALB/c mouse assessed as increase in paw withdrawal latency at 0.1 mg/kg, sc measured 30 mins post dose by hot plate test | ChEMBL. | 23523659 | |
Activity (functional) | Antinociceptive activity in BALB/c mouse assessed as increase in paw withdrawal latency at 1 mg/kg, iv measured 30 mins post dose by hot plate test | ChEMBL. | 23523659 | |
Activity (functional) | Antinociceptive activity in BALB/c mouse assessed as increase in paw withdrawal latency at 1 mg/kg, ip measured 30 mins post dose by hot plate test | ChEMBL. | 23523659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.