Detailed information for compound 1765782

Basic information

Technical information
  • TDR Targets ID: 1765782
  • Name: 5-[(1R,2R)-2-(pyrrolidin-1-ylmethyl)cyclopent yl]-1H-indole-3-carbonitrile
  • MW: 293.406 | Formula: C19H23N3
  • H donors: 1 H acceptors: 1 LogP: 3.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c[nH]c2c1cc(cc2)[C@@H]1CCC[C@H]1CN1CCCC1
  • InChi: 1S/C19H23N3/c20-11-16-12-21-19-7-6-14(10-18(16)19)17-5-3-4-15(17)13-22-8-1-2-9-22/h6-7,10,12,15,17,21H,1-5,8-9,13H2/t15-,17-/m0/s1
  • InChiKey: ZRLNIPQICMTTPJ-RDJZCZTQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[(1R,2R)-2-(1-pyrrolidinylmethyl)cyclopentyl]-1H-indole-3-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0279 0.318 0.318
Onchocerca volvulus 0.0279 0.318 0.318
Schistosoma mansoni SH2A 0.0441 0.5691 0.5691
Echinococcus multilocularis NCK adaptor protein 0.0441 0.5691 0.5691
Loa Loa (eye worm) TK protein kinase 0.0279 0.318 0.318
Plasmodium falciparum tyrosine kinase-like protein 0.0279 0.318 0.5
Toxoplasma gondii STE kinase 0.0279 0.318 0.5
Brugia malayi SH2 domain containing protein 0.0719 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0279 0.318 0.318
Echinococcus granulosus receptor type guanylyl cyclase 0.0279 0.318 0.318
Loa Loa (eye worm) TK protein kinase 0.0279 0.318 0.318
Echinococcus granulosus tyrosine kinase 0.0719 1 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0441 0.5691 0.5691
Schistosoma mansoni ephrin receptor 0.0279 0.318 0.318
Echinococcus granulosus SH2 domain containing adapter protein F 0.0441 0.5691 0.5691
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.318 0.5
Echinococcus multilocularis protein kinase 0.0279 0.318 0.318
Brugia malayi STAT protein, DNA binding domain containing protein 0.0441 0.5691 0.5691
Echinococcus granulosus activated cdc42 kinase 1 0.0279 0.318 0.318
Trypanosoma brucei Pseudokinase, putative 0.0279 0.318 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.318 0.318
Echinococcus granulosus tensin 0.0441 0.5691 0.5691
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0279 0.318 0.5
Brugia malayi SH2 domain containing protein 0.0719 1 1
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Echinococcus multilocularis FL cytokine receptor 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Toxoplasma gondii protein kinase domain-containing protein 0.0279 0.318 0.5
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0279 0.318 0.318
Brugia malayi C-terminal src kinase protein 1 0.0279 0.318 0.318
Echinococcus multilocularis ephrin type A receptor 4 A 0.0279 0.318 0.318
Loa Loa (eye worm) TK/FER protein kinase 0.0719 1 1
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus multilocularis activated cdc42 kinase 1 0.0279 0.318 0.318
Echinococcus multilocularis N chimaerin 0.0441 0.5691 0.5691
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.318 0.5
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0279 0.318 0.318
Brugia malayi Tensin 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Onchocerca volvulus 0.0719 1 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0719 1 1
Brugia malayi Variant SH3 domain containing protein 0.0441 0.5691 0.5691
Loa Loa (eye worm) TK protein kinase 0.0279 0.318 0.318
Trypanosoma cruzi protein kinase, putative 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase pr2 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0719 1 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0719 1 1
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0441 0.5691 0.5691
Schistosoma mansoni GTPase activating protein 0.0441 0.5691 0.5691
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Onchocerca volvulus 0.0441 0.5691 0.5691
Brugia malayi hypothetical protein 0.0279 0.318 0.318
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0441 0.5691 0.5691
Onchocerca volvulus 0.0441 0.5691 0.5691
Loa Loa (eye worm) TK/FER protein kinase 0.0279 0.318 0.318
Brugia malayi Immunoglobulin I-set domain containing protein 0.0279 0.318 0.318
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0279 0.318 0.318
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0279 0.318 0.5
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0279 0.318 0.5
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) TK/FAK protein kinase 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein kinase csk 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0279 0.318 0.318
Plasmodium falciparum protein kinase, putative 0.0279 0.318 0.5
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Loa Loa (eye worm) TK protein kinase 0.0279 0.318 0.318
Loa Loa (eye worm) RGC/RGC protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) TK/RYK protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.318 0.5
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Loa Loa (eye worm) TK/EGFR protein kinase 0.0279 0.318 0.318
Onchocerca volvulus 0.0719 1 1
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Brugia malayi Immunoglobulin I-set domain containing protein 0.0279 0.318 0.318
Echinococcus granulosus SH2 domain containing protein 7 0.0441 0.5691 0.5691
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0719 1 1
Onchocerca volvulus 0.0719 1 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0279 0.318 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0279 0.318 0.318
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Loa Loa (eye worm) SH2 domain-containing protein 0.0441 0.5691 0.5691
Brugia malayi SRC-1 0.0719 1 1
Schistosoma mansoni tensin 0.0441 0.5691 0.5691
Loa Loa (eye worm) TK/ROR protein kinase 0.0332 0.4012 0.4012
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Leishmania major protein kinase, putative 0.0279 0.318 0.5
Echinococcus granulosus suppressor of cytokine signaling 7 0.0441 0.5691 0.5691
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0441 0.5691 0.5691
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0279 0.318 0.318
Echinococcus granulosus retinal guanylyl cyclase 2 0.0279 0.318 0.318
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0279 0.318 0.318
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0441 0.5691 0.5691
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0719 1 1
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Brugia malayi Furin-like cysteine rich region family protein 0.0279 0.318 0.318
Schistosoma mansoni tensin-related 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0279 0.318 0.318
Loa Loa (eye worm) TK/Met protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus multilocularis activin receptor type 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Loa Loa (eye worm) TK/ABL protein kinase 0.0719 1 1
Brugia malayi SH2 domain containing protein 0.0441 0.5691 0.5691
Brugia malayi RhoGAP domain containing protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus multilocularis SH2 motif 0.0441 0.5691 0.5691
Schistosoma mansoni serine/threonine RGC 0.0279 0.318 0.318
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0441 0.5691 0.5691
Trypanosoma brucei Flagellum attachment zone protein 20 0.0279 0.318 0.5
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0441 0.5691 0.5691
Echinococcus multilocularis receptor type guanylyl cyclase 0.0279 0.318 0.318
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Echinococcus granulosus natriuretic peptide receptor 1 0.0279 0.318 0.318
Echinococcus multilocularis SH2 motif 0.0441 0.5691 0.5691
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Loa Loa (eye worm) TK/FER protein kinase 0.0719 1 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) TK protein kinase 0.0279 0.318 0.318
Echinococcus granulosus hypothetical protein 0.0441 0.5691 0.5691
Echinococcus granulosus protein tyrosine kinase 0.0279 0.318 0.318
Echinococcus granulosus activin receptor type 0.0279 0.318 0.318
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0279 0.318 0.318
Echinococcus multilocularis SHC transforming protein 3 0.0441 0.5691 0.5691
Echinococcus multilocularis heat shock protein 70 0.0279 0.318 0.318
Echinococcus granulosus suppressor of cytokine signaling 6 0.0441 0.5691 0.5691
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0279 0.318 0.318
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0441 0.5691 0.5691
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0279 0.318 0.318
Entamoeba histolytica protein kinase, putative 0.0441 0.5691 0.3681
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus granulosus growth factor receptor bound protein 2 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Onchocerca volvulus 0.0441 0.5691 0.5691
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0719 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus granulosus SH2 motif 0.0441 0.5691 0.5691
Brugia malayi Variant SH3 domain containing protein 0.0441 0.5691 0.5691
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Plasmodium falciparum protein kinase, putative 0.0279 0.318 0.5
Echinococcus multilocularis tyrosine protein kinase 0.0279 0.318 0.318
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0441 0.5691 0.5691
Echinococcus multilocularis signal transduction protein lnk realted 0.0441 0.5691 0.5691
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0279 0.318 0.318
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0719 1 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Echinococcus granulosus retinal guanylyl cyclase 2 0.0279 0.318 0.318
Loa Loa (eye worm) SH2 domain-containing protein 0.0441 0.5691 0.5691
Onchocerca volvulus 0.0441 0.5691 0.5691
Echinococcus granulosus fibroblast growth factor receptor 4 0.0279 0.318 0.318
Loa Loa (eye worm) TK/CSK protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Brugia malayi hypothetical protein 0.0279 0.318 0.318
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein kinase Fyn 0.0719 1 1
Schistosoma mansoni suppressor of cytokine signaling 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Schistosoma mansoni nck2/grb4 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0279 0.318 0.318
Loa Loa (eye worm) TK/FER protein kinase 0.0279 0.318 0.318
Onchocerca volvulus 0.0279 0.318 0.318
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0441 0.5691 0.5691
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Brugia malayi Variant SH3 domain containing protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0719 1 1
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Echinococcus multilocularis tensin 0.0441 0.5691 0.5691
Echinococcus granulosus raf serine:threonine protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis protein tyrosine kinase, putative 0.0279 0.318 0.5
Trypanosoma brucei protein kinase, putative 0.0279 0.318 0.5
Echinococcus granulosus tyrosine protein kinase pr2 0.0279 0.318 0.318
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0279 0.318 0.318
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Schistosoma mansoni tyrosine kinase 0.0719 1 1
Brugia malayi SH2 domain containing protein 0.0441 0.5691 0.5691
Loa Loa (eye worm) TK/FER protein kinase 0.0719 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0719 1 1
Schistosoma mansoni tensin 0.0441 0.5691 0.5691
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Loa Loa (eye worm) STAT protein 0.0441 0.5691 0.5691
Entamoeba histolytica SH2 domain containing protein 0.0441 0.5691 0.3681
Echinococcus granulosus signal transduction protein lnk realted 0.0441 0.5691 0.5691
Echinococcus multilocularis epidermal growth factor receptor 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Brugia malayi Raf kinase 0.0279 0.318 0.318
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0441 0.5691 0.5691
Echinococcus granulosus integrin linked protein kinase 0.0279 0.318 0.318
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Echinococcus granulosus activated cdc42 kinase 1 0.0279 0.318 0.318
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0279 0.318 0.318
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0719 1 1
Toxoplasma gondii protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Brugia malayi SH2 domain containing protein 0.0441 0.5691 0.5691
Giardia lamblia Kinase, NEK 0.0279 0.318 0.5
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0719 1 1
Loa Loa (eye worm) TK protein kinase 0.0279 0.318 0.318
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0279 0.318 0.318
Schistosoma mansoni tensin 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0279 0.318 0.5
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus granulosus tyrosine protein kinase HCK 0.0279 0.318 0.318
Echinococcus multilocularis SH2 domain containing protein 7 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Schistosoma mansoni protein tyrosine kinase 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein kinase ABL1 0.0719 1 1
Onchocerca volvulus 0.0719 1 1
Echinococcus multilocularis insulin receptor 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0719 1 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0279 0.318 0.318
Loa Loa (eye worm) TK/FER protein kinase 0.0719 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0719 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0719 1 1
Trichomonas vaginalis protein kinase atn1, putative 0.0279 0.318 0.5
Echinococcus multilocularis tyrosine kinase 0.0719 1 1
Echinococcus multilocularis protein tyrosine kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus granulosus kinase suppressor of Ras 1 0.0279 0.318 0.318
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Giardia lamblia Kinase, NEK 0.0279 0.318 0.5
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Schistosoma mansoni vav2 0.0441 0.5691 0.5691
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0441 0.5691 0.5691
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0279 0.318 0.5
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0279 0.318 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0279 0.318 0.5
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Echinococcus multilocularis protein KINase family member (kin 25) 0.0279 0.318 0.318
Brugia malayi Tyrosine-protein kinase PR2 0.0279 0.318 0.318
Echinococcus granulosus insulin receptor 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Onchocerca volvulus 0.0719 1 1
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0441 0.5691 0.5691
Loa Loa (eye worm) RGC/RGC protein kinase 0.0279 0.318 0.318
Echinococcus granulosus tyrosine kinase 0.0719 1 1
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Echinococcus multilocularis tyrosine protein kinase csk 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase Abl 0.0719 1 1
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0719 1 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein kinase Src64B 0.0719 1 1
Brugia malayi integrin-linked kinase 0.0279 0.318 0.318
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0719 1 1
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Echinococcus granulosus SH2 motif 0.0441 0.5691 0.5691
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0719 1 1
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) TK/ACK protein kinase 0.0279 0.318 0.318
Loa Loa (eye worm) TK/FER protein kinase 0.0719 1 1
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Loa Loa (eye worm) TK/INSR protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Onchocerca volvulus 0.0279 0.318 0.318
Brugia malayi SH2 domain containing protein 0.0441 0.5691 0.5691
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0441 0.5691 0.5691
Loa Loa (eye worm) TK/FER protein kinase 0.0279 0.318 0.318
Loa Loa (eye worm) SRC-1 0.0719 1 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0719 1 1
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.0719 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0719 1 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0279 0.318 0.318
Loa Loa (eye worm) TK/FER protein kinase 0.0279 0.318 0.318
Echinococcus granulosus protein kinase 0.0279 0.318 0.318
Plasmodium falciparum tyrosine kinase-like protein 0.0279 0.318 0.5
Echinococcus granulosus tyrosine kinase 0.0279 0.318 0.318
Brugia malayi cytokine inducible SH2-containing protein 5 0.0441 0.5691 0.5691
Giardia lamblia Kinase 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus granulosus ephrin type A receptor 4 A 0.0279 0.318 0.318
Schistosoma mansoni tyrosine protein kinase 0.0279 0.318 0.318
Echinococcus granulosus c src tyrosine kinase 0.0719 1 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0279 0.318 0.318
Echinococcus granulosus expressed conserved protein 0.0441 0.5691 0.5691
Loa Loa (eye worm) TK/EPH protein kinase 0.0279 0.318 0.318
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Giardia lamblia Protein 21.1 0.0279 0.318 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0279 0.318 0.318
Echinococcus multilocularis SH2 motif 0.0441 0.5691 0.5691
Echinococcus multilocularis tensin 0.0441 0.5691 0.5691
Schistosoma mansoni shc transforming protein 0.0441 0.5691 0.5691
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0441 0.5691 0.5691
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0279 0.318 0.318
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0441 0.5691 0.5691
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0441 0.5691 0.5691
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.318 0.5
Onchocerca volvulus 0.0279 0.318 0.318
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0279 0.318 0.318
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0332 0.4012 0.4012
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0719 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0441 0.5691 0.5691
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Brugia malayi SH2 domain containing protein 0.0441 0.5691 0.5691
Brugia malayi Variant SH3 domain containing protein 0.0441 0.5691 0.5691
Schistosoma mansoni signal transduction protein lnk-related 0.0441 0.5691 0.5691
Echinococcus multilocularis tyrosine kinase 0.0279 0.318 0.318
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Brugia malayi hypothetical protein 0.0719 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0279 0.318 0.5
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0719 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0719 1 1
Schistosoma mansoni tensin-related 0.0441 0.5691 0.5691
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0719 1 1
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Loa Loa (eye worm) TK protein kinase 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0441 0.5691 0.5691
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0441 0.5691 0.5691
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Plasmodium falciparum protein kinase, putative 0.0279 0.318 0.5
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0279 0.318 0.318
Leishmania major hypothetical protein, conserved 0.0279 0.318 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0279 0.318 0.318
Brugia malayi Sex muscle abnormal protein 5 0.0441 0.5691 0.5691
Echinococcus granulosus tyrosine protein kinase csk 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0719 1 1
Brugia malayi hypothetical protein 0.0441 0.5691 0.5691
Schistosoma mansoni tyrosine kinase 0.0719 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein kinase shark 0.0719 1 1
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Echinococcus granulosus epidermal growth factor receptor 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Trypanosoma cruzi protein kinase, putative 0.0279 0.318 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.318 0.5
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0719 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0441 0.5691 0.5691
Brugia malayi Receptor family ligand binding region containing protein 0.0279 0.318 0.318
Onchocerca volvulus 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase Srms 0.0719 1 1
Echinococcus granulosus tyrosine protein kinase 0.0279 0.318 0.318
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0279 0.318 0.318
Echinococcus multilocularis integrin linked protein kinase 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0719 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0279 0.318 0.318
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0441 0.5691 0.5691
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.318 0.5
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0279 0.318 0.318
Onchocerca volvulus 0.0279 0.318 0.318
Echinococcus multilocularis transfer RNA-Thr 0.0279 0.318 0.318
Schistosoma mansoni hypothetical protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) TK protein kinase 0.0279 0.318 0.318
Echinococcus multilocularis natriuretic peptide receptor 1 0.0279 0.318 0.318
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0441 0.5691 0.5691
Echinococcus granulosus tyrosine protein kinase Fyn 0.0719 1 1
Trichomonas vaginalis TK family protein kinase 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Onchocerca volvulus 0.0441 0.5691 0.5691
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.318 0.318
Echinococcus multilocularis protein kinase 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0719 1 1
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Leishmania major protein kinase, putative 0.0279 0.318 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0441 0.5691 0.5691
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Loa Loa (eye worm) TK protein kinase 0.0719 1 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0 0.5
Echinococcus granulosus N chimaerin 0.0441 0.5691 0.5691
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.318 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0441 0.5691 0.5691
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0279 0.318 0.318
Trichomonas vaginalis AGC family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0719 1 1
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Echinococcus granulosus tyrosine protein kinase Src42A 0.0719 1 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0441 0.5691 0.5691
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0441 0.5691 0.5691
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0719 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0719 1 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0441 0.5691 0.5691
Echinococcus granulosus SHC transforming protein 3 0.0441 0.5691 0.5691
Echinococcus multilocularis 0.0441 0.5691 0.5691
Schistosoma mansoni tyrosine kinase 0.0719 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0719 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0441 0.5691 0.5691
Echinococcus multilocularis tyrosine protein kinase HCK 0.0279 0.318 0.318
Trichomonas vaginalis STE family protein kinase 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) hypothetical protein 0.0719 1 1
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Brugia malayi SH2 domain containing protein 0.0441 0.5691 0.5691
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein kinase csk 0.0279 0.318 0.318
Onchocerca volvulus 0.0441 0.5691 0.5691
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0441 0.5691 0.3681
Echinococcus granulosus NCK adaptor protein 0.0441 0.5691 0.5691
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Loa Loa (eye worm) TK/FER protein kinase 0.0279 0.318 0.318
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein kinase Fyn 0.0719 1 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0441 0.5691 0.5691
Loa Loa (eye worm) TK/FER protein kinase 0.0719 1 1
Onchocerca volvulus Tyrosine kinase homolog 0.0279 0.318 0.318
Schistosoma mansoni protein kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0719 1 1
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Onchocerca volvulus 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase Blk 0.0719 1 1
Plasmodium vivax protein kinase, putative 0.0279 0.318 0.5
Brugia malayi SH2 domain containing protein 0.0441 0.5691 0.5691
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0279 0.318 0.318
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0279 0.318 0.318
Brugia malayi Guanylyl cyclase protein 23 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0279 0.318 0.318
Loa Loa (eye worm) TK/DDR protein kinase 0.0279 0.318 0.318
Brugia malayi Tyrosine-protein kinase abl-1 0.0719 1 1
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0719 1 1
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Brugia malayi bone morphogenetic protein type 1 receptor 0.0279 0.318 0.318
Brugia malayi protein-tyrosine kinase 0.0719 1 1
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Brugia malayi ephrin receptor 1 precursor 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0719 1 1
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0441 0.5691 0.5691
Loa Loa (eye worm) hypothetical protein 0.0441 0.5691 0.5691
Schistosoma mansoni adapter molecule crk 0.0441 0.5691 0.5691
Schistosoma mansoni hypothetical protein 0.0441 0.5691 0.5691
Onchocerca volvulus 0.0719 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0279 0.318 0.318
Brugia malayi Protein kinase domain containing protein 0.0719 1 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0279 0.318 0.5
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Onchocerca volvulus 0.0279 0.318 0.318
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0279 0.318 0.5
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Schistosoma mansoni ephrin receptor 0.0279 0.318 0.318
Loa Loa (eye worm) serine/threonine protein kinase 0.0279 0.318 0.318
Echinococcus multilocularis tyrosine protein kinase csk 0.0279 0.318 0.318
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.318 0.318
Plasmodium vivax tyrosine kinase-like protein, putative 0.0279 0.318 0.5
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0279 0.318 0.318
Trichomonas vaginalis TKL family protein kinase 0.0279 0.318 0.5
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0279 0.318 0.318
Schistosoma mansoni hypothetical protein 0.0279 0.318 0.318
Loa Loa (eye worm) hypothetical protein 0.0279 0.318 0.318
Schistosoma mansoni tyrosine kinase 0.0279 0.318 0.318
Onchocerca volvulus 0.0279 0.318 0.318
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0279 0.318 0.318
Loa Loa (eye worm) TK protein kinase 0.0279 0.318 0.318

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 300 nM Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranes ChEMBL. 23578689

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.