Detailed information for compound 1766105

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.824 | Formula: C18H21ClN2O3
  • H donors: 0 H acceptors: 3 LogP: 3.49 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CCN1C(=O)CC(=O)N(C1=O)[C@@H]1CCC[C@@H]1C
  • InChi: 1S/C18H21ClN2O3/c1-12-3-2-4-15(12)21-17(23)11-16(22)20(18(21)24)10-9-13-5-7-14(19)8-6-13/h5-8,12,15H,2-4,9-11H2,1H3/t12-,15+/m0/s1
  • InChiKey: ZBMFHOJQGNDBJA-SWLSCSKDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1D subunit Starlite/ChEMBL References
Oryctolagus cuniculus Voltage-gated L-type calcium channel alpha-1C subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.386 1 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0186 0.0107 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis fmrfamide receptor 0.0201 0.0146 0.0119
Brugia malayi hypothetical protein 0.0201 0.0146 0.004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Schistosoma mansoni biogenic amine (5HT) receptor 0.0201 0.0146 0.0119
Echinococcus granulosus neuropeptide Y receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus granulosus tm gpcr rhodopsin 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.2103 0.5268 0.5065
Schistosoma mansoni neuropeptide F-like receptor 0.0201 0.0146 0.0119
Schistosoma mansoni biogenic amine receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.0107 0.008
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Schistosoma mansoni amine GPCR 0.0201 0.0146 0.0119
Brugia malayi hypothetical protein 0.0201 0.0146 0.004
Brugia malayi neuropeptide F receptor 0.0201 0.0146 0.004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0201 0.0146 0.004
Schistosoma mansoni voltage-gated cation channel 0.0186 0.0107 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.0107 0.008
Schistosoma mansoni biogenic amine receptor 0.0201 0.0146 0.0119
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Schistosoma mansoni neuropeptide receptor 0.0201 0.0146 0.0119
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0201 0.0146 0.004
Plasmodium vivax unspecified product 0.386 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Schistosoma mansoni histamine h1 receptor 0.0201 0.0146 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.0146 0.0119
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0201 0.0146 0.004
Schistosoma mansoni neuropeptide f receptor 76f 0.0201 0.0146 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0201 0.0146 0.004
Brugia malayi sulfakinin receptor protein 0.0201 0.0146 0.004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0201 0.0146 0.0119
Echinococcus granulosus neuropeptide receptor 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0201 0.0146 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Echinococcus granulosus tachykinin peptides receptor 99D 0.0201 0.0146 0.0119
Echinococcus multilocularis neuropeptide receptor 0.0201 0.0146 0.0119
Brugia malayi Dopamine receptor 0.0201 0.0146 0.004
Echinococcus granulosus hypothetical protein 0.0201 0.0146 0.0119
Echinococcus granulosus casein kinase ii subunit alpha 0.386 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0201 0.0146 0.0119
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0201 0.0146 0.0119
Brugia malayi Dopamine receptor protein 1 0.0201 0.0146 0.004
Echinococcus granulosus voltage dependent calcium channel 0.0186 0.0107 0.008
Echinococcus granulosus 7tm_1 domain containing protein 0.0201 0.0146 0.0119
Echinococcus multilocularis fmrfamide receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Schistosoma mansoni opsin-like receptor 0.0201 0.0146 0.0119
Giardia lamblia Casein kinase II beta chain 0.2103 0.5268 0.5065
Giardia lamblia Casein kinase II beta chain 0.0614 0.126 0.0884
Giardia lamblia Kinase, CMGC CK2 0.386 1 1
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0614 0.126 0.0884
Echinococcus multilocularis neuropeptide FF receptor 2 0.0201 0.0146 0.0119
Brugia malayi ORL1-like opioid receptor 0.0201 0.0146 0.004
Echinococcus multilocularis G-protein coupled receptor, putative 0.0201 0.0146 0.0119
Echinococcus granulosus neuropeptide s receptor 0.0201 0.0146 0.0119
Brugia malayi larval opioid receptor 0.0201 0.0146 0.004
Echinococcus granulosus tm gpcr rhodopsin 0.0201 0.0146 0.0119
Brugia malayi GnHR receptor homolog 0.0201 0.0146 0.004
Echinococcus granulosus orexin receptor type 2 0.0201 0.0146 0.0119
Echinococcus granulosus neuropeptide receptor A26 0.0201 0.0146 0.0119
Schistosoma mansoni hypothetical protein 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0614 0.126 0.0884
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Echinococcus granulosus neuropeptide Y receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus multilocularis g protein coupled receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0201 0.0146 0.0119
Leishmania major casein kinase II, putative 0.386 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0201 0.0146 0.0119
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Brugia malayi follicle stimulating hormone receptor 0.0201 0.0146 0.004
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0186 0.0107 0.008
Brugia malayi neuropeptide F receptor 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Trichomonas vaginalis CMGC family protein kinase 0.386 1 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.2103 0.5268 1
Schistosoma mansoni protein kinase 0.386 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0201 0.0146 0.004
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0201 0.0146 0.0119
Schistosoma mansoni hypothetical protein 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0201 0.0146 0.0119
Echinococcus granulosus dro:myosuppressin receptor 0.0201 0.0146 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.0146 0.0119
Loa Loa (eye worm) G-protein coupled receptor 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.0107 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.2103 0.5268 0.5065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.0146 0.0119
Schistosoma mansoni biogenic amine (5HT) receptor 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Loa Loa (eye worm) TYRA-2 protein 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Brugia malayi Melatonin receptor type 1A 0.0201 0.0146 0.004
Echinococcus granulosus tm gpcr rhodopsin 0.0201 0.0146 0.0119
Schistosoma mansoni adenoreceptor 0.0201 0.0146 0.0119
Echinococcus granulosus alpha 1A adrenergic receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis serotonin receptor 0.0201 0.0146 0.0119
Trichomonas vaginalis CMGC family protein kinase 0.386 1 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Brugia malayi putative neuropeptide receptor NPR1 0.0201 0.0146 0.004
Echinococcus granulosus serotonin receptor 0.0201 0.0146 0.0119
Echinococcus granulosus g protein coupled receptor 0.0201 0.0146 0.0119
Plasmodium falciparum casein kinase 2, alpha subunit 0.386 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0201 0.0146 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Echinococcus multilocularis somatostatin receptor 0.0201 0.0146 0.0119
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) 0.1208 0.2859 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Brugia malayi hypothetical protein 0.0201 0.0146 0.004
Echinococcus granulosus g protein coupled receptor 0.0201 0.0146 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.0146 0.0119
Echinococcus granulosus neuropeptide receptor 0.0201 0.0146 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Schistosoma mansoni amine GPCR 0.0201 0.0146 0.0119
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0201 0.0146 0.0119
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0201 0.0146 0.0119
Brugia malayi G-protein coupled receptor 0.0201 0.0146 0.004
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Schistosoma mansoni opsin-like receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0201 0.0146 0.0119
Echinococcus granulosus casein kinase ii subunit beta 0.2103 0.5268 0.5255
Brugia malayi hypothetical protein 0.0201 0.0146 0.004
Echinococcus granulosus 7TM GPCR rhodopsin 0.0201 0.0146 0.0119
Schistosoma mansoni amine GPCR 0.0201 0.0146 0.0119
Echinococcus multilocularis neuropeptide s receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0201 0.0146 0.004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Brugia malayi G-protein coupled receptor 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Schistosoma mansoni growth hormone secretagogue receptor 0.0201 0.0146 0.0119
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0186 0.0107 0.008
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus multilocularis casein kinase ii subunit beta 0.2103 0.5268 0.5255
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0201 0.0146 0.004
Loa Loa (eye worm) G-protein coupled receptor 0.0201 0.0146 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.0146 0.0119
Trichomonas vaginalis CMGC family protein kinase 0.386 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0201 0.0146 0.0119
Brugia malayi Serotonin receptor 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Brugia malayi G protein-coupled receptor F59B2.13 0.0201 0.0146 0.004
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Entamoeba histolytica protein kinase domain containing protein 0.386 1 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Schistosoma mansoni hypothetical protein 0.0201 0.0146 0.0119
Trichomonas vaginalis CMGC family protein kinase 0.386 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Brugia malayi hypothetical protein 0.0201 0.0146 0.004
Schistosoma mansoni neuropeptide F-like receptor 0.0201 0.0146 0.0119
Schistosoma mansoni myosin xvIII 0.0201 0.0146 0.0119
Echinococcus granulosus sex peptide receptor 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Echinococcus multilocularis g protein coupled receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Trichomonas vaginalis CMGC family protein kinase 0.386 1 1
Trypanosoma cruzi casein kinase II, putative 0.386 1 1
Echinococcus granulosus somatostatin receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis g-protein coupled receptor 0.0201 0.0146 0.0119
Brugia malayi casein kinase II, putaitve 0.0614 0.126 0.1166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Echinococcus multilocularis neuropeptide receptor A26 0.0201 0.0146 0.0119
Entamoeba histolytica casein kinase, putative 0.386 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0201 0.0146 0.0119
Loa Loa (eye worm) melatonin receptor type 1A 0.0201 0.0146 0.004
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Schistosoma mansoni casein kinase II beta subunit 0.2103 0.5268 0.5255
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus granulosus biogenic amine 5HT receptor 0.0201 0.0146 0.0119
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0201 0.0146 0.0119
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0201 0.0146 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.0146 0.0119
Echinococcus granulosus G protein coupled receptor 139 0.0201 0.0146 0.0119
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0186 0.0107 0.008
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Brugia malayi hypothetical protein 0.0201 0.0146 0.004
Echinococcus multilocularis neuropeptides capa receptor 0.0201 0.0146 0.0119
Brugia malayi G protein-coupled receptor 0.0201 0.0146 0.004
Echinococcus granulosus g-protein coupled receptor 0.0201 0.0146 0.0119
Brugia malayi hypothetical protein 0.0201 0.0146 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Trichomonas vaginalis CMGC family protein kinase 0.386 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.0146 0.0119
Schistosoma mansoni biogenic amine receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Brugia malayi RE15519p 0.0201 0.0146 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Brugia malayi hypothetical protein 0.0201 0.0146 0.004
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.0107 0.008
Toxoplasma gondii CMGC kinase, CK2 family 0.386 1 1
Trichomonas vaginalis CMGC family protein kinase 0.386 1 1
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0614 0.126 0.0884
Brugia malayi Serotonin receptor 0.0201 0.0146 0.004
Schistosoma mansoni opsin-like receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis neuropeptide Y receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis sex peptide receptor 0.0201 0.0146 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.0146 0.0119
Echinococcus multilocularis allatostatin A receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis neuropeptides capa receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0201 0.0146 0.0119
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.0107 0.008
Schistosoma mansoni hypothetical protein 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0614 0.126 0.0884
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0201 0.0146 0.0119
Brugia malayi Dopamine receptor protein 2 0.0201 0.0146 0.004
Echinococcus granulosus peptide allatostatin:somatostatin 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0201 0.0146 0.0119
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.0412 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Loa Loa (eye worm) casein kinase II 0.0614 0.126 0.1166
Brugia malayi Csnk2b protein 0.2103 0.5268 0.5217
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0201 0.0146 0.0119
Schistosoma mansoni alpha-1 adrenergic receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus granulosus fmrfamide receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis G protein coupled receptor 139 0.0201 0.0146 0.0119
Trypanosoma brucei Casein kinase II 0.386 1 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Brugia malayi hypothetical protein 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Onchocerca volvulus Casein kinase II subunit beta homolog 0.2103 0.5268 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0201 0.0146 0.0119
Brugia malayi hypothetical protein 0.0201 0.0146 0.004
Brugia malayi putative neuropeptide receptor 0.0201 0.0146 0.004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus multilocularis dro:myosuppressin receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis neuropeptide receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis serotonin receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0201 0.0146 0.004
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0201 0.0146 0.004
Echinococcus granulosus allatostatin A receptor 0.0201 0.0146 0.0119
Echinococcus granulosus biogenic amine 5HT receptor 0.0201 0.0146 0.0119
Echinococcus granulosus g protein coupled receptor 0.0201 0.0146 0.0119
Schistosoma mansoni amine GPCR 0.0201 0.0146 0.0119
Schistosoma mansoni neuropeptide receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus granulosus neuropeptide FF receptor 2 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.0107 0.008
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.1208 0.2859 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.2103 0.5268 0.5065
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus multilocularis orexin receptor type 2 0.0201 0.0146 0.0119
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis g protein coupled receptor 0.0201 0.0146 0.0119
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.1208 0.2859 1
Schistosoma mansoni neuropeptide receptor 0.0201 0.0146 0.0119
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Loa Loa (eye worm) neuropeptide F receptor 0.0201 0.0146 0.004
Echinococcus granulosus neuropeptides capa receptor 0.0201 0.0146 0.0119
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.2103 0.5268 0.5065
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.386 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.0146 0.0119
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0186 0.0107 0.008
Trichomonas vaginalis casein kinase II beta chain, putative 0.0614 0.126 0.0884
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus granulosus neuropeptides capa receptor 0.0201 0.0146 0.0119
Loa Loa (eye worm) Csnk2b protein 0.2103 0.5268 0.5217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.0146 0.0119
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0201 0.0146 0.0119
Echinococcus multilocularis casein kinase ii subunit alpha 0.386 1 1
Brugia malayi AKH receptor 0.0201 0.0146 0.004
Schistosoma mansoni amine GPCR 0.0201 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0201 0.0146 0.004
Schistosoma mansoni neuropeptide receptor 0.0201 0.0146 0.0119

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.8 uM Antagonist activity at rat CaV1.3alpha1D transfected in HEK293 cells by FLIPR assay ChEMBL. 23651412
IC50 (binding) = 10 uM Antagonist activity at rabbit CaV1.2alpha1C transfected in HEK293 cells by FLIPR assay ChEMBL. 23651412

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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