Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | para nitrobenzyl esterase | 0.058 | 0.1636 | 0.1636 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0439 | 0.0439 |
Echinococcus granulosus | BC026374 protein S09 family | 0.058 | 0.1636 | 0.1636 |
Onchocerca volvulus | 0.0193 | 0.0502 | 0.0522 | |
Onchocerca volvulus | 0.058 | 0.1636 | 1 | |
Echinococcus multilocularis | neuroligin | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3435 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.058 | 0.1636 | 0.1636 |
Brugia malayi | Carboxylesterase family protein | 0.058 | 0.1636 | 0.1636 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.058 | 0.1636 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3435 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3435 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3435 | 1 | 1 |
Brugia malayi | Pleckstrin Homology Domain | 0.0027 | 0.0015 | 0.0015 |
Brugia malayi | C1-like domain containing protein | 0.0194 | 0.0504 | 0.0504 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0502 | 0.0502 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | carboxylesterase | 0.058 | 0.1636 | 0.1636 |
Brugia malayi | hypothetical protein | 0.058 | 0.1636 | 0.1636 |
Onchocerca volvulus | 0.058 | 0.1636 | 1 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.058 | 0.1636 | 0.1636 |
Onchocerca volvulus | 0.0199 | 0.0519 | 0.0664 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.058 | 0.1636 | 0.1636 |
Brugia malayi | Carboxylesterase family protein | 0.3435 | 1 | 1 |
Onchocerca volvulus | 0.058 | 0.1636 | 1 | |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0194 | 0.0504 | 0.0504 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3435 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.3435 | 1 | 1 |
Onchocerca volvulus | 0.058 | 0.1636 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.3435 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0194 | 0.0504 | 0.0504 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.058 | 0.1636 | 0.5 |
Onchocerca volvulus | 0.058 | 0.1636 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 0.1636 | 0.1636 |
Echinococcus granulosus | neuroligin | 0.058 | 0.1636 | 0.1636 |
Schistosoma mansoni | vav2 | 0.0027 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 0.1636 | 0.1636 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.058 | 0.1636 | 0.1636 |
Schistosoma mansoni | protein kinase C mu | 0.0194 | 0.0504 | 0.0504 |
Schistosoma mansoni | gliotactin | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 0.1636 | 0.1636 |
Echinococcus granulosus | acetylcholinesterase | 0.3435 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.058 | 0.1636 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.058 | 0.1636 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.058 | 0.1636 | 0.1636 |
Schistosoma mansoni | acetylcholinesterase | 0.058 | 0.1636 | 0.1636 |
Echinococcus granulosus | acetylcholinesterase | 0.3435 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.058 | 0.1636 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3435 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.058 | 0.1636 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0015 | 0.0015 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.058 | 0.1636 | 0.1636 |
Brugia malayi | Carboxylesterase family protein | 0.058 | 0.1636 | 0.1636 |
Echinococcus granulosus | myotubularin protein 13 | 0.0027 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0173 | 0.0441 | 0.0441 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0027 | 0.0015 | 0.0015 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.058 | 0.1636 | 0.1636 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.058 | 0.1636 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.3435 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.068 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.443 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.98 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.773 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.714 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.71 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.661 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.592 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.425 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.