Detailed information for compound 1766347

Basic information

Technical information
  • TDR Targets ID: 1766347
  • Name: (5Z)-5-[(3-hydroxy-4-methoxyphenyl)methyliden e]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-th iazolidin-4-one
  • MW: 373.446 | Formula: C18H15NO4S2
  • H donors: 1 H acceptors: 2 LogP: 4.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1C(=S)S/C(=C\c2ccc(c(c2)O)OC)/C1=O
  • InChi: 1S/C18H15NO4S2/c1-22-13-6-4-12(5-7-13)19-17(21)16(25-18(19)24)10-11-3-8-15(23-2)14(20)9-11/h3-10,20H,1-2H3/b16-10-
  • InChiKey: MJWYTOCVVHIXAN-YBEGLDIGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(3-hydroxy-4-methoxyphenyl)methylidene]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one
  • (5Z)-5-[(3-hydroxy-4-methoxy-phenyl)methylene]-3-(4-methoxyphenyl)-2-thioxo-thiazolidin-4-one
  • 5-[(3-hydroxy-4-methoxy-phenyl)methylene]-3-(4-methoxyphenyl)-2-thioxo-thiazolidin-4-one
  • (5Z)-5-[(3-hydroxy-4-methoxyphenyl)methylene]-3-(4-methoxyphenyl)-2-thioxo-4-thiazolidinone
  • 5-[(3-hydroxy-4-methoxyphenyl)methylene]-3-(4-methoxyphenyl)-2-thioxo-4-thiazolidinone
  • (5Z)-5-(3-hydroxy-4-methoxy-benzylidene)-3-(4-methoxyphenyl)-2-thioxo-thiazolidin-4-one
  • 5-(3-hydroxy-4-methoxy-benzylidene)-3-(4-methoxyphenyl)-2-thioxo-thiazolidin-4-one
  • 5-[(3-hydroxy-4-methoxy-phenyl)methylidene]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one
  • (5Z)-5-[(3-hydroxy-4-methoxy-phenyl)methylidene]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one
  • ZINC01192119
  • STK059879

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.036 0.2981 0.2946
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0306 0.2226 0.4996
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0184 0.055 0.0502
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0322 0.2455 0.2417
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0467 0.4455 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0868 1 1
Loa Loa (eye worm) hypothetical protein 0.0567 0.5837 0.5816
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0226 0.1128 0.1083
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0306 0.2226 0.4292
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0306 0.2226 0.4292
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0467 0.4455 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0214 0.0955 0.091
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0164 0.0264 0.0594
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0467 0.4455 0.4427
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0467 0.4455 0.4427
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0527 0.5285 0.5262
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0214 0.0955 0.091
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0306 0.2229 0.4947
Loa Loa (eye worm) hypothetical protein 0.0214 0.0955 0.091
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.036 0.2981 0.6228
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.036 0.2981 0.2946
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0148 0.005 0.005
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0164 0.0264 0.0487
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0467 0.4455 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0467 0.4455 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0527 0.5285 0.5262
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0467 0.4455 0.5
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0161 0.023 0.5
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0467 0.4455 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0567 0.5837 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0467 0.4455 0.4427
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0467 0.4455 0.7168
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0467 0.4455 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0214 0.0955 0.091
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0467 0.4455 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0467 0.4455 0.4427
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0467 0.4455 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0214 0.0955 0.091
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0184 0.055 0.0502
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0306 0.2229 0.219
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0467 0.4455 0.5
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0467 0.4455 0.4427
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0184 0.055 0.1135
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.036 0.2981 0.6693
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0868 1 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0467 0.4455 0.4427
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.036 0.2981 0.6693
Loa Loa (eye worm) hypothetical protein 0.0439 0.4073 0.4044
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0467 0.4455 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0567 0.5837 0.5817
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0306 0.2229 0.219
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.055 0.1135
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.036 0.2981 0.415
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0467 0.4455 0.5
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0467 0.4455 0.4427
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0567 0.5837 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0467 0.4455 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0567 0.5837 0.5837
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0226 0.1128 0.1083
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0184 0.055 0.0502
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0467 0.4455 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0184 0.055 0.1135
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0184 0.055 0.1234
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0868 1 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0161 0.0226 0.0226
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.036 0.2981 0.6228
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0467 0.4455 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.036 0.2981 0.415
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0467 0.4455 0.4427
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.055 0.1135
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0214 0.0955 0.091
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0467 0.4455 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0467 0.4455 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0148 0.005 0.005
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0467 0.4455 0.7168
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.055 0.1135
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0306 0.2229 0.4947
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0467 0.4455 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0184 0.055 0.1234
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0467 0.4455 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0164 0.0264 0.0487
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0161 0.0226 0.04
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0467 0.4455 0.5
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Loa Loa (eye worm) hypothetical protein 0.0226 0.1128 0.1083
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0306 0.2229 0.219
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0322 0.2455 0.2417
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0306 0.2226 0.4996
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0467 0.4455 1
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0161 0.023 0.5
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0567 0.5837 0.5817
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0467 0.4455 0.4455
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0467 0.4455 0.5
Loa Loa (eye worm) PDE1B protein 0.0868 1 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0467 0.4455 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0567 0.5837 0.5817
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.055 0.1135
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0467 0.4455 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0306 0.2226 0.363
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0306 0.2229 0.219
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.055 0.1135
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0226 0.1128 0.1128
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0184 0.055 0.1135
Loa Loa (eye worm) hypothetical protein 0.0306 0.2229 0.219
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0467 0.4455 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0467 0.4455 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.055 0.1135
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0184 0.055 0.1234

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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