TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 339.367 | Formula: C18H18FN5O
H donors: 1 H acceptors: 3 LogP: 2.6 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(nc1)N1CCN(CC1)CC(=O)c1n[nH]c2c1cccc2
InChi: 1S/C18H18FN5O/c19-13-5-6-17(20-11-13)24-9-7-23(8-10-24)12-16(25)18-14-3-1-2-4-15(14)21-22-18/h1-6,11H,7-10,12H2,(H,21,22)
InChiKey: XEANZBDDEUWZMV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	solute carrier family 27 (fatty acid transporter), member 1	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 27 (fatty acid transporter), member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Get druggable targets OG5_127399	All targets in OG5_127399
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	Get druggable targets OG5_127399	All targets in OG5_127399
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_127399	All targets in OG5_127399
Leishmania donovani	fatty acid transporter protein-like protein	Get druggable targets OG5_127399	All targets in OG5_127399
Leishmania infantum	fatty acid transporter protein-like protein	Get druggable targets OG5_127399	All targets in OG5_127399
Echinococcus granulosus	long chain fatty acid transport protein 4	Get druggable targets OG5_127399	All targets in OG5_127399
Schistosoma japonicum	ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative	Get druggable targets OG5_127399	All targets in OG5_127399
Schistosoma japonicum	Long-chain fatty acid transport protein 4, putative	Get druggable targets OG5_127399	All targets in OG5_127399
Echinococcus multilocularis	long chain fatty acid transport protein 4	Get druggable targets OG5_127399	All targets in OG5_127399
Loa Loa (eye worm)	AMP-binding enzyme family protein	Get druggable targets OG5_127399	All targets in OG5_127399
Leishmania braziliensis	fatty acid transporter protein-like protein	Get druggable targets OG5_127399	All targets in OG5_127399
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Get druggable targets OG5_127399	All targets in OG5_127399
Trypanosoma cruzi	fatty acid transporter protein-like, putative	Get druggable targets OG5_127399	All targets in OG5_127399
Mycobacterium leprae	possible long-chain acyl-CoA synthase	Get druggable targets OG5_127399	All targets in OG5_127399
Schistosoma mansoni	FFA transport protein	Get druggable targets OG5_127399	All targets in OG5_127399
Leishmania mexicana	fatty acid transporter protein-like protein	Get druggable targets OG5_127399	All targets in OG5_127399
Leishmania major	fatty acid transporter protein-like protein	Get druggable targets OG5_127399	All targets in OG5_127399
Trypanosoma cruzi	fatty acid transporter protein-like, putative	Get druggable targets OG5_127399	All targets in OG5_127399
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_127399	All targets in OG5_127399

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	solute carrier family 27 (fatty acid transporter), member 1	646 aa	519 aa	20.4 %
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	solute carrier family 27 (fatty acid transporter), member 1	646 aa	552 aa	22.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Brugia malayi	integrin-linked kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	SHC transforming protein 3	0.1026	0.3761	0.3667
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	SH2 domain containing protein 7	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK/Met protein kinase	0.1389	0.5392	0.5392
Brugia malayi	Immunoglobulin I-set domain containing protein	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1026	0.3761	0.3667
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2415	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Echinococcus granulosus	tyrosine protein kinase csk	0.1389	0.5392	0.5323
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK protein kinase	0.1389	0.5392	0.5392
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1026	0.3761	0.3667
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.1026	0.3761	0.3667
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0231	0.0189	0.5
Brugia malayi	hypothetical protein	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.1389	0.5392	0.5323
Leishmania major	hypothetical protein, conserved	0.1389	0.5392	1
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Onchocerca volvulus		0.1026	0.3761	0.3667
Toxoplasma gondii	protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1026	0.3761	0.3761
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1026	0.3761	0.3667
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine kinase	0.2415	1	1
Brugia malayi	ephrin receptor 1 precursor	0.1389	0.5392	0.5323
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1026	0.3761	0.3667
Brugia malayi	Variant SH3 domain containing protein	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK/FER protein kinase	0.1389	0.5392	0.5392
Echinococcus multilocularis	kinase suppressor of Ras 1	0.1389	0.5392	0.5323
Loa Loa (eye worm)	TK/FER protein kinase	0.1389	0.5392	0.5392
Plasmodium falciparum	protein kinase, putative	0.1389	0.5392	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.1389	0.5392	0.5323
Loa Loa (eye worm)	TK protein kinase	0.1389	0.5392	0.5392
Echinococcus granulosus	SHC transforming protein 3	0.1026	0.3761	0.3667
Plasmodium falciparum	tyrosine kinase-like protein	0.1389	0.5392	0.5
Entamoeba histolytica	ankyrin repeat protein	0.1389	0.5392	0.2615
Echinococcus granulosus	activated cdc42 kinase 1	0.1389	0.5392	0.5323
Trypanosoma brucei	Pseudokinase, putative	0.1389	0.5392	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.1389	0.5392	0.5323
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.1389	0.5392	0.5323
Onchocerca volvulus		0.1026	0.3761	0.3667
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.1389	0.5392	0.5323
Echinococcus multilocularis	natriuretic peptide receptor 1	0.1389	0.5392	0.5323
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	integrin linked protein kinase	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Brugia malayi	Furin-like cysteine rich region family protein	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Onchocerca volvulus		0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2415	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1026	0.3761	0.3667
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2415	1	1
Schistosoma mansoni	tyrosine kinase	0.2415	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.1389	0.5392	0.5
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2415	1	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.1389	0.5392	0.5323
Onchocerca volvulus		0.1026	0.3761	0.3667
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.1389	0.5392	0.5323
Loa Loa (eye worm)	RGC/RGC protein kinase	0.1389	0.5392	0.5392
Onchocerca volvulus		0.1389	0.5392	0.5323
Loa Loa (eye worm)	TK/ALK protein kinase	0.1389	0.5392	0.5392
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.1389	0.5392	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	ankyrin repeat protein	0.1389	0.5392	0.2615
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.1389	0.5392	1
Plasmodium falciparum	protein kinase, putative	0.1389	0.5392	0.5
Loa Loa (eye worm)	hypothetical protein	0.0369	0.0811	0.0811
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2415	1	1
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2415	1	1
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	TK/FER protein kinase	0.1389	0.5392	0.5392
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.1389	0.5392	0.5323
Loa Loa (eye worm)	SH2 domain-containing protein	0.1026	0.3761	0.3761
Entamoeba histolytica	receptor protein kinase, putative	0.1389	0.5392	0.2615
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1026	0.3761	0.3667
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.1389	0.5392	0.5392
Brugia malayi	SRC-1	0.2415	1	1
Brugia malayi	SH2 domain containing protein	0.1026	0.3761	0.3667
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Entamoeba histolytica	tyrosin kinase, putative	0.1389	0.5392	0.2615
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Echinococcus multilocularis	FL cytokine receptor	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1026	0.3761	0.3667
Entamoeba histolytica	serine/threonine kinase, putative	0.1389	0.5392	0.2615
Schistosoma mansoni	signal transduction protein lnk-related	0.1026	0.3761	0.3667
Giardia lamblia	Kinase, NEK	0.1389	0.5392	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2415	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2415	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.1389	0.5392	0.5323
Trichomonas vaginalis	AGC family protein kinase	0.1389	0.5392	0.5
Giardia lamblia	Protein 21.1	0.1389	0.5392	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1026	0.3761	0.3667
Echinococcus granulosus	tyrosine protein kinase pr2	0.1389	0.5392	0.5323
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK protein kinase	0.1389	0.5392	0.5392
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.1389	0.5392	0.5323
Onchocerca volvulus		0.1026	0.3761	0.3667
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Brugia malayi	Tyrosine-protein kinase abl-1	0.2415	1	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.1389	0.5392	0.5323
Schistosoma mansoni	growth factor receptor-bound protein	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK/CSK protein kinase	0.1389	0.5392	0.5392
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1026	0.3761	0.3761
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2415	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.1389	0.5392	0.5392
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Loa Loa (eye worm)	SH2 domain-containing protein	0.1026	0.3761	0.3761
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Plasmodium vivax	protein kinase, putative	0.1389	0.5392	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.1389	0.5392	0.2615
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	tyrosine protein kinase	0.1389	0.5392	0.5323
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.1389	0.5392	0.5323
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1026	0.3761	0.3667
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1026	0.3761	0.3667
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2415	1	1
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.1389	0.5392	0.5323
Toxoplasma gondii	STE kinase	0.1389	0.5392	0.5
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Echinococcus multilocularis	tensin	0.1026	0.3761	0.3667
Leishmania major	protein kinase, putative	0.1389	0.5392	1
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1026	0.3761	0.3667
Entamoeba histolytica	serine/threonine kinase, putative	0.1389	0.5392	0.2615
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Echinococcus multilocularis	tensin	0.1026	0.3761	0.3667
Onchocerca volvulus		0.2415	1	1
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Loa Loa (eye worm)	TK/FER protein kinase	0.2415	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Entamoeba histolytica	serine/threonine kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	STAT protein	0.1026	0.3761	0.3761
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	raf serine:threonine protein kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	tyrosine kinase	0.1389	0.5392	0.5323
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.1389	0.5392	1
Echinococcus granulosus	tyrosine protein kinase	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.1389	0.5392	0.5323
Echinococcus multilocularis	tyrosine protein kinase csk	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	TK protein kinase	0.1389	0.5392	0.5392
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.1389	0.5392	0.5323
Echinococcus multilocularis	raf serine:threonine protein kinase	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Leishmania major	protein kinase, putative	0.1389	0.5392	1
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Echinococcus granulosus	expressed conserved protein	0.1026	0.3761	0.3667
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.1389	0.5392	0.5323
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1026	0.3761	0.3667
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1026	0.3761	0.3667
Echinococcus granulosus	epidermal growth factor receptor	0.1389	0.5392	0.5323
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	TK/FER protein kinase	0.2415	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2415	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.1389	0.5392	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2415	1	1
Schistosoma mansoni	tyrosine kinase	0.2415	1	1
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.2415	1	1
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Onchocerca volvulus		0.1389	0.5392	0.5323
Giardia lamblia	Kinase, NEK	0.1389	0.5392	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1026	0.3761	0.3667
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Schistosoma mansoni	SH2A	0.1026	0.3761	0.3667
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Echinococcus multilocularis	tyrosine protein kinase csk	0.1389	0.5392	0.5323
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2415	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.2415	1	1
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Onchocerca volvulus		0.2415	1	1
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Schistosoma mansoni	shc transforming protein	0.1026	0.3761	0.3667
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.1389	0.5392	0.5323
Brugia malayi	Receptor family ligand binding region containing protein	0.1389	0.5392	0.5323
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.1389	0.5392	0.5323
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.1389	0.5392	0.5392
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2415	1	1
Echinococcus granulosus	protein tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	tensin	0.1026	0.3761	0.3667
Schistosoma mansoni	suppressor of cytokine signaling	0.1026	0.3761	0.3667
Entamoeba histolytica	receptor protein kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	TK/EGFR protein kinase	0.1389	0.5392	0.5392
Schistosoma mansoni	hypothetical protein	0.1026	0.3761	0.3667
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Schistosoma mansoni	protein tyrosine kinase	0.1389	0.5392	0.5323
Loa Loa (eye worm)	SRC-1	0.2415	1	1
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Brugia malayi	Variant SH3 domain containing protein	0.1026	0.3761	0.3667
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.1389	0.5392	0.5323
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1026	0.3761	0.3667
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.1389	0.5392	0.5323
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0369	0.0811	0.0673
Brugia malayi	SH2 domain containing protein	0.1026	0.3761	0.3667
Echinococcus granulosus	tyrosine protein kinase csk	0.1389	0.5392	0.5323
Echinococcus multilocularis	activated cdc42 kinase 1	0.1389	0.5392	0.5323
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.1389	0.5392	0.5
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Brugia malayi	Guanylyl cyclase protein 23	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2415	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Schistosoma mansoni	serine/threonine protein kinase	0.1389	0.5392	0.5323
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0222	0.0148	0.0148
Schistosoma mansoni	tensin	0.1026	0.3761	0.3667
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Trichomonas vaginalis	conserved hypothetical protein	0.1389	0.5392	0.5
Onchocerca volvulus		0.1389	0.5392	0.5323
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Entamoeba histolytica	tyrosin kinase, putative	0.1389	0.5392	0.2615
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.1389	0.5392	0.5323
Trypanosoma cruzi	protein kinase, putative	0.1389	0.5392	1
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.1026	0.3761	0.3667
Echinococcus granulosus	insulin receptor	0.1389	0.5392	0.5323
Loa Loa (eye worm)	TK/ROR protein kinase	0.1389	0.5392	0.5392
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Echinococcus granulosus	activated cdc42 kinase 1	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2415	1	1
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.1389	0.5392	0.5323
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1026	0.3761	0.3761
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Loa Loa (eye worm)	TK protein kinase	0.1389	0.5392	0.5392
Echinococcus multilocularis	insulin receptor	0.1389	0.5392	0.5323
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.2415	1	1
Echinococcus granulosus	integrin linked protein kinase	0.1389	0.5392	0.5323
Entamoeba histolytica	hypothetical protein, conserved	0.1389	0.5392	0.2615
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1389	0.5392	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.1389	0.5392	0.5323
Loa Loa (eye worm)	TK/FER protein kinase	0.1389	0.5392	0.5392
Echinococcus granulosus	SH2 motif	0.1026	0.3761	0.3667
Schistosoma mansoni	tensin	0.1026	0.3761	0.3667
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0221	0.0144	0.5
Loa Loa (eye worm)	TK protein kinase	0.1389	0.5392	0.5392
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.1389	0.5392	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1026	0.3761	0.3761
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Echinococcus multilocularis	NCK adaptor protein	0.1026	0.3761	0.3667
Schistosoma mansoni	tyrosine kinase	0.2415	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.1026	0.3761	0.3667
Loa Loa (eye worm)	SH2 domain-containing protein	0.1026	0.3761	0.3761
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Trypanosoma brucei	protein kinase, putative	0.1389	0.5392	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1026	0.3761	0.3667
Trypanosoma cruzi	protein kinase, putative	0.1389	0.5392	1
Echinococcus multilocularis	heat shock protein 70	0.1389	0.5392	0.5323
Trichomonas vaginalis	conserved hypothetical protein	0.1389	0.5392	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Brugia malayi	Tensin	0.1026	0.3761	0.3667
Echinococcus multilocularis	protein tyrosine kinase	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	SH2 motif	0.1026	0.3761	0.3667
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2415	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.1389	0.5392	0.5323
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1026	0.3761	0.3667
Entamoeba histolytica	tyrosin kinase, putative	0.1389	0.5392	0.2615
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1026	0.3761	0.3667
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.1389	0.5392	0.5323
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Trichomonas vaginalis	CAMK family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.1389	0.5392	0.5
Onchocerca volvulus		0.2415	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2415	1	1
Schistosoma mansoni	tensin-related	0.1026	0.3761	0.3667
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	activin receptor type	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Trichomonas vaginalis	conserved hypothetical protein	0.1389	0.5392	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.1389	0.5392	0.5323
Giardia lamblia	Kinase	0.1389	0.5392	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Loa Loa (eye worm)	TK/FER protein kinase	0.1389	0.5392	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2415	1	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.1389	0.5392	0.5323
Echinococcus granulosus	epidermal growth factor receptor	0.1389	0.5392	0.5323
Onchocerca volvulus		0.1389	0.5392	0.5323
Trypanosoma brucei	Flagellum attachment zone protein 20	0.1389	0.5392	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1026	0.3761	0.3667
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Schistosoma mansoni	ephrin receptor	0.1389	0.5392	0.5323
Echinococcus multilocularis		0.1026	0.3761	0.3667
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Brugia malayi	Protein kinase domain containing protein	0.2415	1	1
Echinococcus multilocularis	SH2 motif	0.1026	0.3761	0.3667
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Echinococcus granulosus	kinase suppressor of Ras 1	0.1389	0.5392	0.5323
Schistosoma mansoni	nck2/grb4	0.1026	0.3761	0.3667
Onchocerca volvulus		0.1389	0.5392	0.5323
Onchocerca volvulus		0.1389	0.5392	0.5323
Brugia malayi	Variant SH3 domain containing protein	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK/EPH protein kinase	0.1389	0.5392	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1026	0.3761	0.3667
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Schistosoma mansoni	vav2	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.1389	0.5392	0.5392
Echinococcus multilocularis	SH2 motif	0.1026	0.3761	0.3667
Echinococcus multilocularis	N chimaerin	0.1026	0.3761	0.3667
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	TK/INSR protein kinase	0.1389	0.5392	0.5392
Echinococcus multilocularis	SH2 motif	0.1026	0.3761	0.3667
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2415	1	1
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2415	1	1
Echinococcus granulosus	tyrosine kinase	0.2415	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.1389	0.5392	0.5
Trichomonas vaginalis	STE family protein kinase	0.1389	0.5392	0.5
Onchocerca volvulus		0.2415	1	1
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Loa Loa (eye worm)	TK/RYK protein kinase	0.1389	0.5392	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Onchocerca volvulus		0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1389	0.5392	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.2415	1	1
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	transfer RNA-Thr	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Schistosoma mansoni	GTPase activating protein	0.1026	0.3761	0.3667
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Echinococcus granulosus	retinal guanylyl cyclase 2	0.1389	0.5392	0.5323
Brugia malayi	SH2 domain containing protein	0.1026	0.3761	0.3667
Schistosoma mansoni	serine/threonine protein kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	tyrosine kinase	0.2415	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK/FER protein kinase	0.2415	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.1389	0.5392	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.1389	0.5392	0.5392
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.1389	0.5392	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.1389	0.5392	0.5323
Brugia malayi	bone morphogenetic protein type 1 receptor	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1026	0.3761	0.3667
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.1389	0.5392	0.5323
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.1389	0.5392	0.5323
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2415	1	1
Brugia malayi	RhoGAP domain containing protein	0.1026	0.3761	0.3667
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.1389	0.5392	0.5392
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0369	0.0811	0.1249
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.1389	0.5392	1
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1026	0.3761	0.3667
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Brugia malayi	SH2 domain containing protein	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK protein kinase	0.1389	0.5392	0.5392
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2415	1	1
Brugia malayi	Protein kinase domain containing protein	0.2415	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Echinococcus multilocularis	c src tyrosine kinase	0.2415	1	1
Schistosoma mansoni	tensin-related	0.1026	0.3761	0.3667
Trichomonas vaginalis	protein kinase atn1, putative	0.1389	0.5392	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2415	1	1
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Brugia malayi	hypothetical protein	0.2415	1	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.1389	0.5392	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.1389	0.5392	0.2615
Onchocerca volvulus		0.2415	1	1
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Loa Loa (eye worm)	TK protein kinase	0.1389	0.5392	0.5392
Echinococcus granulosus	tyrosine protein kinase csk	0.1389	0.5392	0.5323
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.1389	0.5392	0.5323
Plasmodium vivax	tyrosine kinase-like protein, putative	0.1389	0.5392	0.5
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Entamoeba histolytica	serine/threonine kinase, putative	0.1389	0.5392	0.2615
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2415	1	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.1389	0.5392	0.5323
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Schistosoma mansoni	adapter molecule crk	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK/ABL protein kinase	0.2415	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.1389	0.5392	0.2615
Brugia malayi	SH2 domain containing protein	0.1026	0.3761	0.3667
Brugia malayi	Variant SH3 domain containing protein	0.1026	0.3761	0.3667
Brugia malayi	C-terminal src kinase protein 1	0.1389	0.5392	0.5323
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.1389	0.5392	0.5
Onchocerca volvulus		0.2415	1	1
Mycobacterium leprae	possible long-chain acyl-CoA synthase	0.0221	0.0144	0.5
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Brugia malayi	AMP-binding enzyme family protein	0.0231	0.0189	0.0042
Brugia malayi	Tyrosine-protein kinase PR2	0.1389	0.5392	0.5323
Loa Loa (eye worm)	TK/FER protein kinase	0.2415	1	1
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Echinococcus multilocularis	tyrosine protein kinase csk	0.1389	0.5392	0.5323
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1026	0.3761	0.3667
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Schistosoma mansoni	serine/threonine RGC	0.1389	0.5392	0.5323
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Loa Loa (eye worm)	TK/FER protein kinase	0.2415	1	1
Schistosoma mansoni	tyrosine kinase	0.2415	1	1
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1026	0.3761	0.3761
Echinococcus granulosus	fibroblast growth factor receptor 4	0.1389	0.5392	0.5323
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1026	0.3761	0.3667
Brugia malayi	Raf kinase	0.1389	0.5392	0.5323
Brugia malayi	protein-tyrosine kinase	0.2415	1	1
Echinococcus granulosus	N chimaerin	0.1026	0.3761	0.3667
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	protein kinase	0.1389	0.5392	0.5323
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1026	0.3761	0.3761
Loa Loa (eye worm)	TK/FAK protein kinase	0.1389	0.5392	0.5392
Echinococcus granulosus	protein kinase	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	tyrosine protein kinase HCK	0.1389	0.5392	0.5323
Brugia malayi	SH2 domain containing protein	0.1026	0.3761	0.3667
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.1389	0.5392	0.5323
Brugia malayi	Sex muscle abnormal protein 5	0.1026	0.3761	0.3667
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1026	0.3761	0.3667
Schistosoma mansoni	ephrin receptor	0.1389	0.5392	0.5323
Schistosoma mansoni	FFA transport protein	0.0224	0.0157	0.0009
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.1389	0.5392	0.5
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	long chain fatty acid transport protein 4	0.0224	0.0157	0.0009
Brugia malayi	hypothetical protein	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK/FER protein kinase	0.2415	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Echinococcus granulosus	tyrosine protein kinase HCK	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2415	1	1
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2415	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	RGC/RGC protein kinase	0.1389	0.5392	0.5392
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	hypothetical protein	0.1026	0.3761	0.3667
Loa Loa (eye worm)	RGC/RGC protein kinase	0.1389	0.5392	0.5392
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Toxoplasma gondii	protein kinase domain-containing protein	0.1389	0.5392	0.5
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.1026	0.3761	0.3667
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.1389	0.5392	0.5323
Echinococcus granulosus	NCK adaptor protein	0.1026	0.3761	0.3667
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2415	1	1
Brugia malayi	Protein kinase domain containing protein	0.2415	1	1
Loa Loa (eye worm)	hypothetical protein	0.2415	1	1
Brugia malayi	SH2 domain containing protein	0.1026	0.3761	0.3667
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.1389	0.5392	0.5392
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Brugia malayi	Protein kinase domain containing protein	0.1389	0.5392	0.5323
Brugia malayi	SH2 domain containing protein	0.2415	1	1
Onchocerca volvulus	Tyrosine kinase homolog	0.1389	0.5392	0.5323
Schistosoma mansoni	protein kinase	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.1389	0.5392	0.5323
Leishmania major	C-8 sterol isomerase-like protein	0.0369	0.0811	0.1271
Echinococcus multilocularis	long chain fatty acid transport protein 4	0.0224	0.0157	0.0009
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Entamoeba histolytica	serine/threonine kinase, putative	0.1389	0.5392	0.2615
Brugia malayi	SH2 domain containing protein	0.2415	1	1
Schistosoma mansoni	tyrosine kinase	0.2415	1	1
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Brugia malayi	hypothetical protein	0.1026	0.3761	0.3667
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Plasmodium falciparum	protein kinase, putative	0.1389	0.5392	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1389	0.5392	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2415	1	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.1389	0.5392	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Loa Loa (eye worm)	TK protein kinase	0.1389	0.5392	0.5392
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2415	1	1
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Echinococcus multilocularis	activin receptor type	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1026	0.3761	0.3667
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.1389	0.5392	0.2615
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.1389	0.5392	0.5323
Schistosoma mansoni	tyrosine protein kinase	0.1389	0.5392	0.5323
Echinococcus multilocularis	protein kinase	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase, putative	0.1389	0.5392	0.2615
Echinococcus multilocularis	epidermal growth factor receptor	0.1389	0.5392	0.5323
Loa Loa (eye worm)	TK/FER protein kinase	0.1389	0.5392	0.5392
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2415	1	1
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Entamoeba histolytica	tyrosin kinase, putative	0.1389	0.5392	0.2615
Echinococcus multilocularis	tyrosine protein kinase shark	0.2415	1	1
Loa Loa (eye worm)	TK protein kinase	0.2415	1	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.1389	0.5392	0.5323
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1389	0.5392	0.2615
Echinococcus multilocularis	epidermal growth factor receptor	0.1389	0.5392	0.5323
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.1389	0.5392	0.5
Onchocerca volvulus		0.1026	0.3761	0.3667
Loa Loa (eye worm)	protein kinase domain-containing protein	0.1389	0.5392	0.5392
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Entamoeba histolytica	hypothetical protein	0.1389	0.5392	0.2615
Entamoeba histolytica	tyrosine kinase, putative	0.1389	0.5392	0.2615
Loa Loa (eye worm)	hypothetical protein	0.1389	0.5392	0.5392
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Echinococcus multilocularis	signal transduction protein lnk realted	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK/FER protein kinase	0.2415	1	1
Loa Loa (eye worm)	hypothetical protein	0.1026	0.3761	0.3761
Loa Loa (eye worm)	TK/DDR protein kinase	0.1389	0.5392	0.5392
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.1389	0.5392	0.5323
Echinococcus granulosus	c src tyrosine kinase	0.2415	1	1
Schistosoma mansoni	tensin	0.1026	0.3761	0.3667
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1026	0.3761	0.3667
Loa Loa (eye worm)	TK/FER protein kinase	0.2415	1	1
Schistosoma mansoni	tyrosine kinase	0.1389	0.5392	0.5323
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0231	0.0189	0.0189
Brugia malayi	Immunoglobulin I-set domain containing protein	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Trichomonas vaginalis	protein tyrosine kinase, putative	0.1389	0.5392	0.5
Onchocerca volvulus		0.1026	0.3761	0.3667
Echinococcus multilocularis	tyrosine kinase	0.2415	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.1389	0.5392	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.1389	0.5392	0.5392
Schistosoma mansoni	serine/threonine protein kinase	0.1389	0.5392	0.5323
Onchocerca volvulus		0.1389	0.5392	0.5323
Schistosoma mansoni	hypothetical protein	0.1389	0.5392	0.5323
Entamoeba histolytica	protein kinase domain containing protein	0.1389	0.5392	0.2615
Entamoeba histolytica	cysteine surface protein, putative	0.1389	0.5392	0.2615
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2415	1	1
Schistosoma mansoni	hypothetical protein	0.1026	0.3761	0.3667
Trichomonas vaginalis	TK family protein kinase	0.1389	0.5392	0.5
Trichomonas vaginalis	TKL family protein kinase	0.1389	0.5392	0.5
Echinococcus multilocularis	tyrosine kinase	0.1389	0.5392	0.5323

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 1 uM	Inhibition of human FLAG-tagged FATP1-mediated [1-14C] oleic acid conversion to [1-14C] oleoyl-CoA after 20 mins by scintillation counting analysis	ChEMBL.	23528296
IC50 (binding)	> 10 uM	Inhibition of mouse FLAG-tagged FATP1-mediated [1-14C] oleic acid conversion to [1-14C] oleoyl-CoA after 20 mins by scintillation counting analysis	ChEMBL.	23528296

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2377616

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1766421