Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0136 | 0.058 | 0.058 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0078 | 0.0245 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1792 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0638 | 0.3437 | 1 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0078 | 0.0245 | 0.0245 |
Trypanosoma brucei | protein kinase, putative | 0.1792 | 1 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0078 | 0.0245 | 0.0245 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1792 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0078 | 0.0245 | 0.0245 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0078 | 0.0245 | 0.0245 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0638 | 0.3437 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1792 | 1 | 1 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0078 | 0.0245 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1792 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1792 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0241 | 0.1173 | 0.1173 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0638 | 0.3437 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0078 | 0.0245 | 0.0245 |
Brugia malayi | Pre-SET motif family protein | 0.0241 | 0.1173 | 0.1173 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0078 | 0.0245 | 0.0245 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0638 | 0.3437 | 0.3272 |
Brugia malayi | Isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1792 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0638 | 0.3437 | 0.3437 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1792 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1792 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1792 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1792 | 1 | 1 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0078 | 0.0245 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0638 | 0.3437 | 0.3437 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0245 | 0.0245 |
Schistosoma mansoni | lipoxygenase | 0.0095 | 0.0346 | 0.0346 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0078 | 0.0245 | 0.0245 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0136 | 0.058 | 0.058 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0078 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1792 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0136 | 0.058 | 0.058 |
Trichomonas vaginalis | set domain proteins, putative | 0.0274 | 0.1362 | 0.1145 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1792 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0078 | 0.0245 | 0.0245 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0078 | 0.0245 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1792 | 1 | 1 |
Onchocerca volvulus | 0.0274 | 0.1362 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1792 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0078 | 0.0245 | 0.0245 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0078 | 0.0245 | 0.0245 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0078 | 0.0245 | 0.0245 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0078 | 0.0245 | 0.0245 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1792 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.047 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.