TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 569.482 | Formula: C27H37BrO8
H donors: 2 H acceptors: 4 LogP: 4.63 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H]1CC(=O)O[C@@H]2C[C@@H](CCCCc3cc(O)ccc3Br)O[C@@]3(C2)O[C@@H](CC(=O)O1)CCC3(C)C
InChi: 1S/C27H37BrO8/c1-26(2)10-9-20-13-24(31)34-22(16-29)14-25(32)33-21-12-19(35-27(26,15-21)36-20)6-4-3-5-17-11-18(30)7-8-23(17)28/h7-8,11,19-22,29-30H,3-6,9-10,12-16H2,1-2H3/t19-,20-,21-,22-,27+/m1/s1
InChiKey: XAVHENBENCIKCO-DAACTFMNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase C, delta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/FER protein kinase	0.0474	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Onchocerca volvulus		0.0474	0.9991	1
Entamoeba histolytica	protein kinase domain containing protein	0.0192	0.082	0.001
Schistosoma mansoni	hypothetical protein	0.0282	0.3758	0.3211
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0811	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0282	0.3758	0.3208
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Onchocerca volvulus		0.0282	0.3758	0.3762
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0474	0.9991	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0282	0.3758	0.3211
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0474	0.9991	0.999
Schistosoma mansoni	shc transforming protein	0.0282	0.3758	0.3211
Echinococcus granulosus	tensin	0.0282	0.3758	0.3208
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/FER protein kinase	0.0192	0.0811	0.0811
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0192	0.0811	0.0811
Schistosoma mansoni	tyrosine kinase	0.0474	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.018	0.042	0.042
Echinococcus multilocularis	activin receptor type	0.0192	0.082	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0474	0.9991	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0282	0.3758	0.3762
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/ACK protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/FER protein kinase	0.0192	0.0811	0.0811
Plasmodium falciparum	protein kinase, putative	0.0192	0.082	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0282	0.3758	0.3211
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0192	0.082	1
Brugia malayi	Tensin	0.0282	0.3758	0.3211
Echinococcus granulosus	SH2 motif	0.0282	0.3758	0.3208
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK protein kinase	0.0192	0.0811	0.0811
Schistosoma mansoni	protein kinase	0.0192	0.082	0.001
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/FER protein kinase	0.0474	0.9991	1
Echinococcus granulosus	SHC transforming protein 3	0.0282	0.3758	0.3208
Giardia lamblia	Kinase, NEK	0.0192	0.0811	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0282	0.3758	0.3211
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0474	0.9991	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0282	0.3758	0.3762
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0282	0.3758	0.3762
Brugia malayi	hypothetical protein	0.0282	0.3758	0.3211
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0282	0.3758	0.3762
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0282	0.3758	0.3211
Echinococcus multilocularis	tensin	0.0282	0.3758	0.3211
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0192	0.0811	0.0811
Brugia malayi	Tyrosine-protein kinase abl-1	0.0474	0.9991	1
Schistosoma mansoni	tensin	0.0282	0.3758	0.3211
Echinococcus granulosus	expressed conserved protein	0.0282	0.3758	0.3208
Brugia malayi	Protein kinase domain containing protein	0.0474	0.9991	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0192	0.0811	0.0811
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0474	0.9991	0.999
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0282	0.3758	0.3211
Schistosoma mansoni	tyrosine kinase	0.0474	0.9991	1
Trichomonas vaginalis	CAMK family protein kinase	0.0192	0.0811	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0474	0.9991	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0474	0.9991	1
Echinococcus granulosus	SH2 motif	0.0282	0.3758	0.3208
Loa Loa (eye worm)	TK/FER protein kinase	0.0474	0.9991	1
Brugia malayi	SH2 domain containing protein	0.0282	0.3758	0.3211
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0282	0.3758	0.3211
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0474	0.9991	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0192	0.0811	0.0811
Schistosoma mansoni	growth factor receptor-bound protein	0.0282	0.3758	0.3211
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0474	0.9991	1
Onchocerca volvulus		0.0282	0.3758	0.3762
Loa Loa (eye worm)	TK/INSR protein kinase	0.0192	0.0811	0.0811
Trichomonas vaginalis	STE family protein kinase	0.0192	0.0811	0.5
Onchocerca volvulus		0.0282	0.3758	0.3762
Entamoeba histolytica	SH2 domain containing protein	0.0282	0.3758	0.3211
Loa Loa (eye worm)	hypothetical protein	0.0474	0.9991	1
Echinococcus multilocularis		0.0282	0.3758	0.3211
Echinococcus granulosus	hypothetical protein	0.0282	0.3758	0.3208
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0282	0.3767	0.3221
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0282	0.3758	0.3211
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0192	0.082	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0282	0.3758	0.3208
Loa Loa (eye worm)	STAT protein	0.0282	0.3758	0.3762
Schistosoma mansoni	tensin	0.0282	0.3758	0.3211
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0474	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0291	0.4055	0.3534
Brugia malayi	Variant SH3 domain containing protein	0.0291	0.4055	0.3534
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0192	0.0811	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0474	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0192	0.0811	0.0811
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0291	0.4055	0.3531
Onchocerca volvulus		0.0192	0.0811	0.0811
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0282	0.3758	0.3211
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0474	0.9991	1
Echinococcus granulosus	c src tyrosine kinase	0.0474	0.9991	0.999
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Brugia malayi	SH2 domain containing protein	0.0474	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Schistosoma mansoni	protein kinase	0.0192	0.082	0.001
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0474	0.9991	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0282	0.3758	0.3211
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0192	0.082	1
Onchocerca volvulus		0.0192	0.0811	0.0811
Echinococcus granulosus	tyrosine protein kinase Srms	0.0474	0.9991	0.999
Onchocerca volvulus		0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/FER protein kinase	0.0474	0.9991	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0474	0.9991	0.999
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0282	0.3758	0.3211
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0291	0.4055	0.3534
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Echinococcus multilocularis	N chimaerin	0.0291	0.4055	0.3534
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0282	0.3758	0.3211
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Brugia malayi	SH2 domain containing protein	0.0282	0.3758	0.3211
Loa Loa (eye worm)	TK protein kinase	0.0192	0.0811	0.0811
Echinococcus multilocularis	tyrosine protein kinase shark	0.0474	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0474	0.9991	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0282	0.3758	0.3211
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0282	0.3758	0.3208
Loa Loa (eye worm)	TK/FER protein kinase	0.0474	0.9991	1
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0192	0.082	0.001
Brugia malayi	Variant SH3 domain containing protein	0.0282	0.3758	0.3211
Echinococcus granulosus	N chimaerin	0.0291	0.4055	0.3531
Schistosoma mansoni	adapter molecule crk	0.0282	0.3758	0.3211
Onchocerca volvulus		0.0282	0.3758	0.3762
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0282	0.3758	0.3762
Schistosoma mansoni	GTPase activating protein	0.0282	0.3758	0.3211
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Schistosoma mansoni	tensin-related	0.0282	0.3758	0.3211
Onchocerca volvulus		0.0474	0.9991	1
Echinococcus multilocularis	SHC transforming protein 3	0.0282	0.3758	0.3211
Entamoeba histolytica	protein kinase, putative	0.0282	0.3767	0.3221
Loa Loa (eye worm)	TK protein kinase	0.0192	0.0811	0.0811
Schistosoma mansoni	suppressor of cytokine signaling	0.0282	0.3758	0.3211
Loa Loa (eye worm)	hypothetical protein	0.0176	0.0297	0.0297
Plasmodium vivax	protein kinase, putative	0.0192	0.0811	0.5
Brugia malayi	SH2 domain containing protein	0.0282	0.3758	0.3211
Onchocerca volvulus		0.0282	0.3758	0.3762
Onchocerca volvulus		0.0474	0.9991	1
Onchocerca volvulus		0.0192	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0474	0.9991	1
Onchocerca volvulus		0.0474	0.9991	1
Brugia malayi	protein-tyrosine kinase	0.0474	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0474	0.9991	0.999
Loa Loa (eye worm)	SRC-1	0.0474	0.9991	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0282	0.3758	0.3208
Loa Loa (eye worm)	TK/RYK protein kinase	0.0192	0.0811	0.0811
Brugia malayi	hypothetical protein	0.0474	0.9991	1
Brugia malayi	SH2 domain containing protein	0.0282	0.3758	0.3211
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0811	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0291	0.4055	0.4059
Onchocerca volvulus		0.0192	0.0811	0.0811
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0474	0.9991	1
Echinococcus multilocularis	NCK adaptor protein	0.0282	0.3758	0.3211
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Brugia malayi	Protein kinase domain containing protein	0.0474	0.9991	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0192	0.0811	0.0811
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0474	0.9991	0.999
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0192	0.0811	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0282	0.3758	0.3211
Trichomonas vaginalis	protein kinase atn1, putative	0.0192	0.0811	0.5
Brugia malayi	Protein kinase domain containing protein	0.0474	0.9991	1
Onchocerca volvulus		0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/EPH protein kinase	0.0192	0.0811	0.0811
Schistosoma mansoni	tensin	0.0282	0.3758	0.3211
Schistosoma mansoni	nck2/grb4	0.0282	0.3758	0.3211
Schistosoma mansoni	SH2A	0.0282	0.3758	0.3211
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Schistosoma mansoni	serine/threonine protein kinase	0.0201	0.1107	0.0323
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0192	0.0811	0.0811
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0192	0.0811	0.0811
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0192	0.082	1
Loa Loa (eye worm)	TK protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Echinococcus multilocularis	SH2 domain containing protein 7	0.0282	0.3758	0.3211
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/FER protein kinase	0.0474	0.9991	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0192	0.0811	0.0811
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0474	0.9991	0.999
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0192	0.082	0.001
Giardia lamblia	Protein 21.1	0.0192	0.0811	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0282	0.3758	0.3211
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0282	0.3758	0.3211
Loa Loa (eye worm)	TK/CSK protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0282	0.3758	0.3762
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Onchocerca volvulus		0.0474	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0811	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0474	0.9991	1
Echinococcus granulosus	NCK adaptor protein	0.0282	0.3758	0.3208
Brugia malayi	SH2 domain containing protein	0.0282	0.3758	0.3211
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0192	0.0811	0.0811
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0474	0.9991	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0282	0.3758	0.3208
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0282	0.3758	0.3208
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus multilocularis	SH2 motif	0.0282	0.3758	0.3211
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Brugia malayi	Protein kinase domain containing protein	0.0474	0.9991	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0192	0.0811	0.0811
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0282	0.3758	0.3762
Trichomonas vaginalis	TK family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0282	0.3758	0.3211
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/ALK protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0282	0.3758	0.3762
Echinococcus multilocularis	tyrosine kinase	0.0474	0.9991	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0201	0.1107	0.0323
Schistosoma mansoni	tyrosine kinase	0.0474	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0282	0.3758	0.3211
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Brugia malayi	SH2 domain containing protein	0.0474	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0282	0.3758	0.3208
Schistosoma mansoni	tyrosine kinase	0.0474	0.9991	1
Echinococcus granulosus	activin receptor type	0.0192	0.082	0.001
Echinococcus granulosus	tyrosine kinase	0.0474	0.9991	0.999
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0282	0.3758	0.3211
Onchocerca volvulus		0.0282	0.3758	0.3762
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TK protein kinase	0.0474	0.9991	1
Loa Loa (eye worm)	TK protein kinase	0.0192	0.0811	0.0811
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Onchocerca volvulus		0.0192	0.0811	0.0811
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0474	0.9991	0.999
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0474	0.9991	1
Brugia malayi	SH2 domain containing protein	0.0282	0.3758	0.3211
Echinococcus granulosus	raf serine:threonine protein kinase	0.0201	0.1107	0.0323
Schistosoma mansoni	tyrosine kinase	0.0474	0.9991	1
Onchocerca volvulus		0.0474	0.9991	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0282	0.3758	0.3208
Schistosoma mansoni	protein kinase	0.0192	0.082	0.001
Schistosoma mansoni	tensin-related	0.0282	0.3758	0.3211
Leishmania major	protein kinase, putative	0.0192	0.082	1
Giardia lamblia	Kinase, NEK	0.0192	0.0811	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0282	0.3758	0.3208
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0192	0.0811	0.0811
Brugia malayi	Sex muscle abnormal protein 5	0.0282	0.3758	0.3211
Brugia malayi	Variant SH3 domain containing protein	0.0282	0.3758	0.3211
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0811	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0474	0.9991	0.999
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0474	0.9991	0.999
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0474	0.9991	0.999
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TK protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK protein kinase	0.0192	0.0811	0.0811
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0474	0.9991	0.999
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0474	0.9991	0.999
Brugia malayi	RhoGAP domain containing protein	0.0291	0.4055	0.3534
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0282	0.3758	0.3211
Echinococcus granulosus	growth factor receptor bound protein 2	0.0282	0.3758	0.3208
Brugia malayi	SRC-1	0.0474	0.9991	1
Brugia malayi	Protein kinase domain containing protein	0.0474	0.9991	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0192	0.0811	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0291	0.4055	0.3534
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus multilocularis	tensin	0.0282	0.3758	0.3211
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus multilocularis	SH2 motif	0.0282	0.3758	0.3211
Loa Loa (eye worm)	TK/ROR protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0282	0.3758	0.3762
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Schistosoma mansoni	hypothetical protein	0.0282	0.3758	0.3211
Echinococcus multilocularis	SH2 motif	0.0282	0.3758	0.3211
Loa Loa (eye worm)	TK/Met protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Schistosoma mansoni	vav2	0.0291	0.4055	0.3534
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0474	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0192	0.0811	0.0811
Schistosoma mansoni	signal transduction protein lnk-related	0.0282	0.3758	0.3211
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0192	0.0811	0.0811
Echinococcus granulosus	SH2 domain containing protein 7	0.0282	0.3758	0.3208
Schistosoma mansoni	tyrosine kinase	0.0474	0.9991	1
Echinococcus granulosus	tyrosine kinase	0.0474	0.9991	0.999
Onchocerca volvulus		0.0192	0.0811	0.0811
Loa Loa (eye worm)	SH2 domain-containing protein	0.0282	0.3758	0.3762
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0474	0.9991	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/FER protein kinase	0.0474	0.9991	1
Trichomonas vaginalis	AGC family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/FER protein kinase	0.0474	0.9991	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0474	0.9991	0.999
Schistosoma mansoni	suppressor of cytokine signaling	0.0282	0.3758	0.3211
Echinococcus multilocularis	c src tyrosine kinase	0.0474	0.9991	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Trypanosoma brucei	protein kinase, putative	0.0192	0.082	1
Loa Loa (eye worm)	hypothetical protein	0.0282	0.3758	0.3762
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0474	0.9991	1
Giardia lamblia	Kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK/FER protein kinase	0.0192	0.0811	0.0811
Loa Loa (eye worm)	TK protein kinase	0.0192	0.0811	0.0811
Brugia malayi	SH2 domain containing protein	0.0282	0.3758	0.3211
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0811	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0474	0.9991	1
Onchocerca volvulus		0.0192	0.0811	0.0811
Trichomonas vaginalis	TKL family protein kinase	0.0192	0.0811	0.5
Loa Loa (eye worm)	TK protein kinase	0.0192	0.0811	0.0811

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (ADMET)		Toxicity in ICR mouse assessed as development of tumors at 8.5 nmol treated twice a week from week 1 to week 20	ChEMBL.	23582444
Activity (ADMET)	= 50 %	Cytotoxicity against human Raji cells assessed as cell viability at 10'-7 M	ChEMBL.	23582444
Ki (binding)	= 3.5 nM	Inhibition of [3H]PDBu binding to PKCdelta-C1B domain peptide (unknown origin)	ChEMBL.	23582444
Ki (binding)	= 66 nM	Inhibition of [3H]PDBu binding to PKCdelta-C1A domain peptide (unknown origin)	ChEMBL.	23582444

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2381162

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1766782