Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nervana 2 | 0.2467 | 0.6163 | 0.898 |
Trichomonas vaginalis | AGC family protein kinase | 0.3859 | 1 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.2601 | 0.6533 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1287 | 0.2912 | 0.4457 |
Echinococcus multilocularis | nervana 2 | 0.2467 | 0.6163 | 0.898 |
Trichomonas vaginalis | AGC family protein kinase | 0.3859 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1287 | 0.2912 | 0.4457 |
Trypanosoma cruzi | Protein kinase B | 0.2601 | 0.6533 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.3859 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.3859 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.3859 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1392 | 0.3203 | 0.0516 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.1287 | 0.2912 | 0.2912 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.1287 | 0.2912 | 0.2912 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.3859 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1287 | 0.2912 | 0.4457 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.1287 | 0.2912 | 0.2912 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.2601 | 0.6533 | 0.5109 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.2601 | 0.6533 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.2467 | 0.6163 | 0.898 |
Echinococcus granulosus | nervana 2 | 0.2467 | 0.6163 | 0.898 |
Trichomonas vaginalis | AGC family protein kinase | 0.3859 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.1287 | 0.2912 | 0.2912 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.2467 | 0.6163 | 0.898 |
Trichomonas vaginalis | AGC family protein kinase | 0.3859 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.3753 | 0.9708 | 0.9708 |
Schistosoma mansoni | serine/threonine kinase | 0.1287 | 0.2912 | 0.4457 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.1287 | 0.2912 | 0.2912 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1287 | 0.2912 | 0.4457 |
Toxoplasma gondii | AGC kinase | 0.3753 | 0.9708 | 0.5 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.2495 | 0.6241 | 0.9195 |
Brugia malayi | Protein kinase domain containing protein | 0.1287 | 0.2912 | 0.2912 |
Schistosoma mansoni | atypical protein kinase C | 0.1287 | 0.2912 | 0.4457 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.3753 | 0.9708 | 0.9708 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.2467 | 0.6163 | 0.898 |
Entamoeba histolytica | protein kinase 2, putative | 0.2495 | 0.6241 | 0.4697 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.2495 | 0.6241 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1287 | 0.2912 | 0.4457 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.2601 | 0.6533 | 0.5109 |
Loa Loa (eye worm) | hypothetical protein | 0.1287 | 0.2912 | 0.2912 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.3859 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1287 | 0.2912 | 0.0109 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.2601 | 0.6533 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.1287 | 0.2912 | 0.2912 |
Brugia malayi | Protein kinase domain containing protein | 0.1287 | 0.2912 | 0.2912 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.2495 | 0.6241 | 0.9195 |
Trichomonas vaginalis | AGC family protein kinase | 0.1287 | 0.2912 | 0.0109 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.2601 | 0.6533 | 1 |
Echinococcus multilocularis | nervana 2 | 0.2467 | 0.6163 | 0.898 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.2495 | 0.6241 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.3753 | 0.9708 | 0.9589 |
Brugia malayi | protein kinase C II. | 0.1287 | 0.2912 | 0.2912 |
Trichomonas vaginalis | AGC family protein kinase | 0.3859 | 1 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.2495 | 0.6241 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.2495 | 0.6241 | 0.9195 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.1287 | 0.2912 | 0.2912 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.2467 | 0.6163 | 0.898 |
Echinococcus granulosus | serine/threonine protein kinase | 0.2601 | 0.6533 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1287 | 0.2912 | 0.4457 |
Trichomonas vaginalis | AGC family protein kinase | 0.1287 | 0.2912 | 0.0109 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1287 | 0.2912 | 0.4457 |
Entamoeba histolytica | protein kinase, putative | 0.3859 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 250 nM | Inhibition of CHK1 in human U2OS cells assessed as phosphorylation of H2AX after 2 hrs by FITC/propidium iodide staining-based immunofluorescence assay in presence of hydroxyurea | ChEMBL. | 23535330 |
IC50 (binding) | = 5 nM | Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate after 2 hrs by scintillation proximity assay in presence of [gamma33P]-ATP | ChEMBL. | 23535330 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.