Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0623 | 0.2647 | 0.5 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.1193 | 0.6575 | 0.6138 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.1132 | 0.0002 |
Echinococcus multilocularis | amiloride sensitive amine oxidase | 0.0431 | 0.1329 | 0.0222 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1691 | 1 | 1 |
Schistosoma mansoni | copper/topaquinone oxidase | 0.0431 | 0.1329 | 0.0362 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0623 | 0.2647 | 0.5 |
Echinococcus granulosus | amiloride sensitive amine oxidase | 0.0431 | 0.1329 | 0.0222 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0623 | 0.2647 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0402 | 0.1132 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.1193 | 0.6575 | 0.6138 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0623 | 0.2647 | 0.1709 |
Echinococcus granulosus | dihydrofolate reductase | 0.0623 | 0.2647 | 0.1709 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.1193 | 0.6575 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0623 | 0.2647 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.1132 | 0.0002 |
Brugia malayi | Dihydrofolate reductase | 0.0623 | 0.2647 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0238 | 0 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0623 | 0.2647 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0238 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0402 | 0.1132 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0238 | 0 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0623 | 0.2647 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0623 | 0.2647 | 0.2784 |
Schistosoma mansoni | hypothetical protein | 0.0431 | 0.1329 | 0.0362 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0402 | 0.1132 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.