Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.0231 | 0.1076 | 0.1073 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0742 | 0.3977 | 0.3952 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0173 | 0.0746 | 0.0743 |
Brugia malayi | CHE-14 protein | 0.0742 | 0.3977 | 0.3952 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0185 | 0.0815 | 0.0812 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0231 | 0.1076 | 0.1073 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1803 | 1 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1803 | 1 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0742 | 0.3977 | 0.3975 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0095 | 0.0054 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0846 | 0.4565 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0742 | 0.3977 | 0.3975 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0846 | 0.4565 | 1 |
Echinococcus multilocularis | protein patched | 0.0742 | 0.3977 | 0.3975 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0185 | 0.0815 | 0.0812 |
Schistosoma mansoni | patched 1 | 0.0742 | 0.3977 | 0.3975 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0058 | 0.0095 | 0.0091 |
Echinococcus multilocularis | protein dispatched 1 | 0.0742 | 0.3977 | 0.3975 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1803 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0202 | 0.0908 | 0.0905 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0846 | 0.4565 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0742 | 0.3977 | 0.3975 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0742 | 0.3977 | 0.3975 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0058 | 0.0093 | 0.0089 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1803 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 0.3977 | 0.3952 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0846 | 0.4565 | 1 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0058 | 0.0095 | 0.0091 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0046 | 0.0025 | 0.0022 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0173 | 0.0746 | 0.0743 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0742 | 0.3977 | 0.3975 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1803 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0742 | 0.3977 | 0.3975 |
Loa Loa (eye worm) | hypothetical protein | 0.1803 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1803 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1803 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1803 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.705 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.352 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.175 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.977 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.944 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.879 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.811 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.805 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.769 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.568 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.